Search Results - "D’Souza, Zelpha"

De novo DNA methylation drives 5hmC accumulation in mouse zygotes by Amouroux, Rachel, Nashun, Buhe, Shirane, Kenjiro, Nakagawa, Shoma, Hill, Peter W. S., D’Souza, Zelpha, Nakayama, Manabu, Matsuda, Masashi, Turp, Aleksandra, Ndjetehe, Elodie, Encheva, Vesela, Kudo, Nobuaki R., Koseki, Haruhiko, Sasaki, Hiroyuki, Hajkova, Petra

“…Using ultrasensitive mass spectrometry of wild-type and mutant early mouse zygotes, Hajkova and colleagues show that 5mC loss and 5hmC accumulation are…”
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A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency by Tordo, Julie, O'Leary, Claire, Antunes, André S L M, Palomar, Nuria, Aldrin-Kirk, Patrick, Basche, Mark, Bennett, Antonette, D'Souza, Zelpha, Gleitz, Hélène, Godwin, Annie, Holley, Rebecca J, Parker, Helen, Liao, Ai Yin, Rouse, Paul, Youshani, Amir Saam, Dridi, Larbi, Martins, Carla, Levade, Thierry, Stacey, Kevin B, Davis, Daniel M, Dyer, Adam, Clément, Nathalie, Björklund, Tomas, Ali, Robin R, Agbandje-McKenna, Mavis, Rahim, Ahad A, Pshezhetsky, Alexey, Waddington, Simon N, Linden, R Michael, Bigger, Brian W, Henckaerts, Els

“…Tordo et al. present a novel AAV gene therapy vector, AAV-TT, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables…”
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Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy by Holley, Rebecca J, Ellison, Stuart M, Fil, Daniel, O'Leary, Claire, McDermott, John, Senthivel, Nishanthi, Langford-Smith, Alexander W W, Wilkinson, Fiona L, D'Souza, Zelpha, Parker, Helen, Liao, Aiyin, Rowlston, Samuel, Gleitz, Hélène F E, Kan, Shih-Hsin, Dickson, Patricia I, Bigger, Brian W

“…There are currently no treatments for mucopolysaccharidosis IIIB. Holley et al. develop a lentiviral-driven stem cell gene therapy in mice that corrects…”
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Brain‐targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms by Gleitz, Hélène FE, Liao, Ai Yin, Cook, James R, Rowlston, Samuel F, Forte, Gabriella MA, D'Souza, Zelpha, O'Leary, Claire, Holley, Rebecca J, Bigger, Brian W

“…The pediatric lysosomal storage disorder mucopolysaccharidosis type II is caused by mutations in IDS, resulting in accumulation of heparan and dermatan…”
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Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages by Hull, Richard P, Srivastava, Prashant K, D'Souza, Zelpha, Atanur, Santosh S, Mechta-Grigoriou, Fatima, Game, Laurence, Petretto, Enrico, Cook, H Terence, Aitman, Timothy J, Behmoaras, Jacques

“…The oxidative burst is one of the major antimicrobial mechanisms adopted by macrophages. The WKY rat strain is uniquely susceptible to experimentally induced…”
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Experimental crescentic glomerulonephritis: a new bicongenic rat model by D'Souza, Zelpha, McAdoo, Stephen P, Smith, Jennifer, Pusey, Charles D, Cook, H Terence, Behmoaras, Jacques, Aitman, Timothy J

“…Crescentic glomerulonephritis (CRGN) is a major cause of human kidney failure, but the underlying mechanisms are not fully understood. Wistar Kyoto (WKY) rats…”
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Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease by Kang, Heeseog, Kerloc’h, Audrey, Rotival, Maxime, Xu, Xiaoqing, Zhang, Qing, D’Souza, Zelpha, Kim, Michael, Scholz, Jodi Carlson, Ko, Jeong-Hun, Srivastava, Prashant K., Genzen, Jonathan R., Cui, Weiguo, Aitman, Timothy J., Game, Laurence, Melvin, James E., Hanidu, Adedayo, Dimock, Janice, Zheng, Jie, Souza, Donald, Behera, Aruna K., Nabozny, Gerald, Cook, H. Terence, Bassett, J.H. Duncan, Williams, Graham R., Li, Jun, Vignery, Agnès, Petretto, Enrico, Behmoaras, Jacques

“…Macrophages can fuse to form osteoclasts in bone or multinucleate giant cells (MGCs) as part of the immune response. We use a systems genetics approach in rat…”
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Role of Novel Rat-specific Fc Receptor in Macrophage Activation Associated with Crescentic Glomerulonephritis by Page, Theresa H., D'Souza, Zelpha, Nakanishi, Satoshi, Serikawa, Tadao, Pusey, Charles D., Aitman, Timothy J., Cook, H. Terence, Behmoaras, Jacques

“…Crescentic glomerulonephritis (Crgn) is a complex disease where the initial insult is often the glomerular deposition of antibodies against intrinsic or…”
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AP-1 Transcription Factor JunD Confers Protection from Accelerated Nephrotoxic Nephritis and Control Podocyte-Specific Vegfa Expression by Cook, H. Terence, Tarzi, Ruth, D'Souza, Zelpha, Laurent, Gaelle, Lin, Wei-Chou, Aitman, Timothy J, Mechta-Grigoriou, Fatima, Behmoaras, Jacques

“…Genetic investigation of crescentic glomerulonephritis (Crgn) susceptibility in the Wistar Kyoto rat, a strain uniquely susceptible to nephrotoxic nephritis…”
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Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1[beta] synthesis in macrophages by Hull, Richard P, Srivastava, Prashant K, D'Souza, Zelpha, Atanur, Santosh S, Mechta-Grigoriou, Fatima, Game, Laurence, Petretto, Enrico, Cook, H Terence, Aitman, Timothy J, Behmoaras, Jacques

“…The oxidative burst is one of the major antimicrobial mechanisms adopted by macrophages. The WKY rat strain is uniquely susceptible to experimentally induced…”
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Genetic Loci Modulate Macrophage Activity and Glomerular Damage in Experimental Glomerulonephritis by BEHMOARAS, Jacques, SMITH, Jennifer, D'SOUZA, Zelpha, BHANGAL, Gurjeet, CHAWANASUNTOROPOJ, Ratana, TAM, Frederick W. K, PUSEY, Charles D, AITMAN, Timothy J, TERENCE COOK, H

“…The Wistar Kyoto (WKY) rat is uniquely susceptible to experimentally induced crescentic glomerulonephritis. Two major quantitative trait loci (QTLs) on…”
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Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains by Maratou, K, Behmoaras, J, Fewings, C, Srivastava, P, D'Souza, Z, Smith, J, Game, L, Cook, T, Aitman, T

“…Crescentic glomerulonephritis (CRGN) is a major cause of rapidly progressive renal failure for which the underlying genetic basis is unknown. Wistar–Kyoto…”
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