Search Results - "D’Avila, Joana C."

Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy by Moraes, Carolina A., Hottz, Eugenio D., Dos Santos Ornellas, Débora, Adesse, Daniel, de Azevedo, Carolina T., d’Avila, Joana C., Zaverucha-do-Valle, Camila, Maron-Gutierrez, Tatiana, Barbosa, Helene Santos, Bozza, Patricia Torres, Bozza, Fernando Augusto

“…Acute cerebral dysfunction is a pathological state common in severe infections and a pivotal determinant of long-term cognitive outcomes. Current evidence…”
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Bioenergetics, mitochondrial dysfunction, and oxidative stress in the pathophysiology of septic encephalopathy by Bozza, Fernando A, D'Avila, Joana C, Ritter, Cristiane, Sonneville, Romain, Sharshar, Tarek, Dal-Pizzol, Felipe

“…Sepsis is a major cause of mortality and morbidity in intensive care units. Acute and long-term brain dysfunctions have been demonstrated both in experimental…”
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Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis by Moraes, Carolina A., Santos, Gabriel, Spohr, Tania Cristina Leite de Sampaio e, D’Avila, Joana C., Lima, Flávia Regina Souza, Benjamim, Claudia Farias, Bozza, Fernando A., Gomes, Flávia Carvalho Alcantara

“…Recent clinical studies have shown that sepsis survivors may develop long-term cognitive impairments. The cellular and molecular mechanisms involved in these…”
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Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor by d'Avila, Joana C, Lam, Tina I, Bingham, Deborah, Shi, Jian, Won, Seok Joon, Kauppinen, Tiina M, Massa, Stephen, Liu, Jialing, Swanson, Raymond A

“…Traumatic brain injury (TBI) induces activation of microglia. Activated microglia can in turn increase secondary injury and impair recovery. This innate immune…”
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Cerebral Multimodal Monitoring in Sepsis: An Experimental Study by Kurtz, Pedro, d’Avila, Joana C, Prado, Darwin, Madeira, Caroline, Vargas-Lopes, Charles, Panizzutti, Rogerio, Azevedo, Luciano Cesar Pontes, Bozza, Fernando A

“…ABSTRACTAcute brain dysfunction is a complication of sepsis and its pathophysiology remains poorly understood. We studied the brain metabolism in a…”
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Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria by Reis, Patricia A, Estato, Vanessa, da Silva, Tathiany I, d'Avila, Joana C, Siqueira, Luciana D, Assis, Edson F, Bozza, Patricia T, Bozza, Fernando A, Tibiriça, Eduardo V, Zimmerman, Guy A, Castro-Faria-Neto, Hugo C

“…Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a…”
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In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping by Towner, Rheal A, Garteiser, Philippe, Bozza, Fernando, Smith, Nataliya, Saunders, Debra, d′Avila, Joana C.P, Magno, Flora, Oliveira, Marcus F, Ehrenshaft, Marilyn, Lupu, Florea, Silasi-Mansat, Robert, Ramirez, Dario C, Gomez-Mejiba, Sandra E, Mason, Ronald P, Castro Faria-Neto, Hugo C

“…Free radicals are known to play a major role in sepsis. Combined immuno-spin trapping and molecular magnetic resonance imaging (MRI) was used to detect in vivo…”
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Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection by Oliveira, Marcus F., d'Avila, Joana C. P., Tempone, Antônio J., Correâ Soares, Juliana B. R., Rumjanek, Franklin D., Ferreira-Pereira, Antônio, Ferreira, Sérgio T., Oliveira, Pedro L.

“…Adult Schistosoma mansoni digest large amounts of host hemoglobin and release potentially toxic heme inside their guts. We have previously demonstrated that…”
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Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction by Reis, Patricia A, Alexandre, Pedro C.B, D’Avila, Joana C, Siqueira, Luciana D, Antunes, Barbara, Estato, Vanessa, Tibiriça, Eduardo V, Verdonk, Franck, Sharshar, Tarek, Chrétien, Fabrice, Castro-Faria-Neto, Hugo C, Bozza, Fernando A

“…Highlights • Sepsis induces neuroinflammation, endothelial dysfunction and cognitive decline in mice; • Statins prevent cognitive impairment after sepsis…”
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The role of Nox2-derived ROS in the development of cognitive impairment after sepsis by Hernandes, Marina S, D'Avila, Joana C, Trevelin, Silvia C, Reis, Patricia A, Kinjo, Erika R, Lopes, Lucia R, Castro-Faria-Neto, Hugo C, Cunha, Fernando Q, Britto, Luiz R G, Bozza, Fernando A

“…Sepsis- associated encephalopathy (SAE) is an early and common feature of severe infections. Oxidative stress is one of the mechanisms associated with the…”
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Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M pro , Impairing Variants Replication In Vitro and In Vivo by Chaves, Otávio Augusto, Sacramento, Carolina Q, Ferreira, André C, Mattos, Mayara, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R, Vazquez, Leonardo, Pinto, Douglas Pereira, da Silveira, Gabriel P E, da Fonseca, Laís Bastos, Pereira, Heliana Martins, Carlos, Aluana Santana, d'Avila, Joana C, Viola, João P B, Monteiro, Robson Q, Bozza, Patrícia T, Castro-Faria-Neto, Hugo Caire, Souza, Thiago Moreno L

“…Atazanavir (ATV) has already been considered as a potential repurposing drug to 2019 coronavirus disease (COVID-19); however, there are controversial reports…”
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Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo by Chaves, Otávio Augusto, Sacramento, Carolina Q., Ferreira, André C., Mattos, Mayara, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R., Vazquez, Leonardo, Pinto, Douglas Pereira, da Silveira, Gabriel P. E., da Fonseca, Laís Bastos, Pereira, Heliana Martins, Carlos, Aluana Santana, d’Avila, Joana C., Viola, João P. B., Monteiro, Robson Q., Bozza, Patrícia T., Castro-Faria-Neto, Hugo Caire, Souza, Thiago Moreno L.

“…Atazanavir (ATV) has already been considered as a potential repurposing drug to 2019 coronavirus disease (COVID-19); however, there are controversial reports…”
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Extracellular lipid droplets promote hemozoin crystallization in the gut of the blood fluke Schistosoma mansoni by Corrêa Soares, Juliana B.R., Maya-Monteiro, Clarissa M., Bittencourt-Cunha, Paula R.B., Atella, Geórgia C., Lara, Flávio A., d’Avila, Joana C.P., Menezes, Diego, Vannier-Santos, Marcos A., Oliveira, Pedro L., Egan, Timothy J., Oliveira, Marcus F.

“…Hemozoin (Hz) is a heme crystal produced upon hemoglobin digestion as the main mechanism of heme disposal in several hematophagous organisms. Here, we show…”
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Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1[beta]: Implications for Cognitive Impairment in Sepsis by Moraes, Carolina A, Santos, Gabriel, Spohr, Tania Cristina; Leite De; Sampaio E, D'avila, Joana C, Lima, Flávia Regina; Souza, Benjamim, Claudia Farias, Bozza, Fernando A, Gomes, Flávia Carvalho; Alcantara

“…Recent clinical studies have shown that sepsis survivors may develop long-term cognitive impairments. The cellular and molecular mechanisms involved in these…”
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Role of NOX2-derived ROS in the development of cognitive impairment after sepsis by D'Avila, Joana C, Hernandes, Marina S, Trevelin, Silvia C, Reis, Patricia A, Castro-Faria-Neto, Hugo, Cunha, Fernando Q, Britto, Luiz RG, Bozza, Fernando A

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