Search Results - "D’Aprile, Simona"
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The Role of Epigenetics in Neuroinflammatory-Driven Diseases
Published in International journal of molecular sciences (02-12-2022)“…Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context,…”
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Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing
Published in Cell death & disease (16-06-2021)“…Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells. In…”
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3
Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
Published in Scientific reports (05-09-2024)“…Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to…”
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4
Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain
Published in Inflammation research (01-10-2024)“…Background and objective Neuropathic pain is a chronic condition characterized by aberrant signaling within the somatosensory system, affecting millions of…”
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Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance
Published in Journal of translational medicine (03-11-2023)“…Abstract Background Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a…”
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6
Growth and development of succulent mixtures for extensive green roofs in a Mediterranean climate
Published in PloS one (03-06-2022)“…Green roof systems, aimed at reducing anthropic impact on the environment, are considered environmental mitigation technologies and adopted by many countries…”
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7
The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression
Published in Biomedicines (30-03-2022)“…In 2021 the World Health Organization published the fifth and latest version of the Central Nervous System tumors classification, which incorporates and…”
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Neurotrophic and immunomodulatory effects of olfactory ensheathing cells as a strategy for neuroprotection and regeneration
Published in Frontiers in immunology (19-12-2022)“…Accumulating evidence sustains glial cells as critical players during central nervous system (CNS) development, homeostasis and disease. Olfactory ensheathing…”
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Enzymatic Synthesis of New Acetoacetate-Ursodeoxycholic Acid Hybrids as Potential Therapeutic Agents and Useful Synthetic Scaffolds as Well
Published in Molecules (Basel, Switzerland) (01-03-2024)“…Ursodeoxycholic acid (UDCA) and acetoacetate are natural compounds present in the human intestine and blood, respectively. A number of studies highlighted that…”
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10
Application of PGPB Combined with Variable N Doses Affects Growth, Yield-Related Traits, N-Fertilizer Efficiency and Nutritional Status of Lettuce Grown under Controlled Condition
Published in Agronomy (Basel) (01-02-2022)“…Nitrogen (N) fertilization is a crucial agricultural practice for boosting production traits in vegetables. However, N synthetic fertilizers—commonly adopted…”
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Epigenetics and Metabolism Reprogramming Interplay into Glioblastoma: Novel Insights on Immunosuppressive Mechanisms
Published in Antioxidants (18-01-2023)“…The central nervous system represents a complex environment in which glioblastoma adapts skillfully, unleashing a series of mechanisms suitable for its…”
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12
Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
Published in Communications biology (08-04-2023)“…Despite aggressive therapeutic regimens, glioblastoma (GBM) represents a deadly brain tumor with significant aggressiveness, radioresistance and…”
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13
Green Roofs as Effective Tools for Improving the Indoor Comfort Levels of Buildings—An Application to a Case Study in Sicily
Published in Applied sciences (01-02-2020)“…In the line of pursuing better energy efficiency in human activities that would result in a more sustainable utilization of resources, the building sector…”
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14
Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software
Published in BioMedInformatics (01-03-2024)“…In the era of digitalization, the biomedical sector has been affected by the spread of artificial intelligence. In recent years, the possibility of using deep…”
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15
Enzymatic Synthesis of Ascorbic Acid-Ketone Body Hybrids
Published in Catalysts (01-04-2023)“…Molecular hybrids obtained by connecting two or more bioactive molecules through a metabolizable linker are used as multi-target drugs for the therapy of…”
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Differential effect of nine cinnamic acid derivatives on the biocatalytic activity of Candida antarctica lipase type B
Published in Current research in biotechnology (2024)“…[Display omitted] •CaLB prodrug synthesis of nine cinnamic acid derivatives evaluated by docking.•Experimental validation confirms Hydroxyl group’s…”
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Studies on Sedum taxa found in Sicily (Italy) for Mediterranean extensive green roofs
Published in Italian journal of agronomy (22-01-2018)“…One type of green roof whose function is ecological and environmental rather than aesthetic is the extensive green roof. Many studies have shown that Sedum…”
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Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off‐target effect of radiotherapy
Published in Cell proliferation (01-06-2024)“…Glioblastoma (GBM), a WHO grade IV glioma, is a malignant primary brain tumour for which combination of surgery, chemotherapy and radiotherapy is the…”
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Effects of plant density and cutting-type on rooting and growth of an extensive green roof of Sedum sediforme (Jacq.) Pau in a Mediterranean environment
Published in Scientia horticulturae (27-02-2020)“…•Single and combined effects of two cutting-type affected rooting and cover of Sedum.•Stem-tip cutting rooted faster and had higher rooting percentages than…”
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Satisfaction, quality of life and therapy adherence assessment in real life patients transitioning from vitamin K antagonists to direct oral anticoagulants
Published in Journal of thrombosis and thrombolysis (01-10-2020)“…Anticoagulant therapy has undergone a significant change since direct oral anticoagulants (DOACs) introduction. Their obvious advantages including the fixed…”
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