Search Results - "D’Andrea, Mario"

Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma by De Mattia, Elena, Cecchin, Erika, Guardascione, Michela, Foltran, Luisa, Di Raimo, Tania, Angelini, Francesco, D'Andrea, Mario, Toffoli, Giuseppe

“…Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage,…”
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Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy by De Re, Valli, Caggiari, Laura, De Zorzi, Mariangela, Talamini, Renato, Racanelli, Vito, D' Andrea, Mario, Buonadonna, Angela, Zagonel, Vittorina, Cecchin, Erika, Innocenti, Federico, Toffoli, Giuseppe

“…To explore genes of the killer-cell immunoglobulin-like receptor (KIR) and of the HLA ligand and their relationship with the outcome of metastatic colorectal…”
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HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment by Garziera, Marica, Bidoli, Ettore, Cecchin, Erika, Mini, Enrico, Nobili, Stefania, Lonardi, Sara, Buonadonna, Angela, Errante, Domenico, Pella, Nicoletta, D'Andrea, Mario, De Marchi, Francesco, De Paoli, Antonino, Zanusso, Chiara, De Mattia, Elena, Tassi, Renato, Toffoli, Giuseppe

“…An important hallmark of CRC is the evasion of immune surveillance. HLA-G is a negative regulator of host's immune response. Overexpression of HLA-G protein in…”
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Propensity for Early Metastatic Spread in Breast Cancer: Role of Tumor Vascularization Features and Tumor Immune Infiltrate by D’Andrea, Mario Rosario, Cereda, Vittore, Coppola, Luigi, Giordano, Guido, Remo, Andrea, De Santis, Elena

“…Breast cancer is a complex and highly heterogeneous disease consisting of various subtypes. It is classified into human epidermal growth receptor 2…”
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Oxaliplatin-related neurotoxicity: How and why? by Pasetto, Lara Maria, D’Andrea, Mario Rosario, Rossi, Elena, Monfardini, Silvio

“…In early clinical trials, oxaliplatin has demonstrated significant activity against colorectal cancer in combination with 5-fluorouracil (5-FU) and folinic…”
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Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients by Labriet, Adrien, Lévesque, Éric, Cecchin, Erika, De Mattia, Elena, Villeneuve, Lyne, Rouleau, Michèle, Jonker, Derek, Couture, Félix, Simonyan, David, Allain, Eric P., Buonadonna, Angela, D’Andrea, Mario, Toffoli, Giuseppe, Guillemette, Chantal

“…This study investigated the potential of single nucleotide polymorphisms as predictors of survival in two cohorts comprising 417 metastatic colorectal cancer…”
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Combination of the PARPi and ARSi in advanced castration resistant prostate cancer: a review of the recent phase III trials by Panebianco, Martina, Cereda, Vittore, D'Andrea, Mario Rosario

“…Tumors with an impaired ability to repair DNA double-strand breaks by homologous recombination, including those with alterations in breast cancer 1 and 2 ( and…”
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Predictive Role of the UGT1A1, UGT1A7, and UGT1A9 Genetic Variants and Their Haplotypes on the Outcome of Metastatic Colorectal Cancer Patients Treated With Fluorouracil, Leucovorin, and Irinotecan by CECCHIN, Erika, INNOCENTI, Federico, D'ANDREA, Mario, CORONA, Giuseppe, DE MATTIA, Elena, BIASON, Paola, BUONADONNA, Angela, TOFFOLI, Giuseppe

“…UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity outcome of irinotecan-treated patients. We evaluated the effect of other UGT1A…”
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The Genotype for DPYD Risk Variants in Patients With Colorectal Cancer and the Related Toxicity Management Costs in Clinical Practice by Toffoli, Giuseppe, Innocenti, Federico, Polesel, Jerry, De Mattia, Elena, Sartor, Franca, Dalle Fratte, Chiara, Ecca, Fabrizio, Dreussi, Eva, Palazzari, Elisa, Guardascione, Michela, Buonadonna, Angela, Foltran, Luisa, Garziera, Marica, Bignucolo, Alessia, Nobili, Stefania, Mini, Enrico, Favaretto, Adolfo, Berretta, Massimiliano, D'Andrea, Mario, De Paoli, Antonino, Roncato, Rossana, Cecchin, Erika

“…Lack of information on the clinical utility of preemptive DPYD screening before fluoropyrimidine treatment is a major barrier preventing its use in clinical…”
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Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients by Labriet, Adrien, Lévesque, Éric, De Mattia, Elena, Cecchin, Erika, Jonker, Derek, Couture, Félix, Simonyan, David, Buonadonna, Angela, D'Andrea, Mario, Villeneuve, Lyne, Toffoli, Giuseppe, Guillemette, Chantal

“…Germline variants could modify survival of metastatic colorectal cancer patients (mCRC). The association of 285 haplotype-tagging SNPs in 11 candidate genes…”
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Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment by De Mattia, Elena, Toffoli, Giuseppe, Polesel, Jerry, D’Andrea, Mario, Corona, Giuseppe, Zagonel, Vittorina, Buonadonna, Angela, Dreussi, Eva, Cecchin, Erika

“…OBJECTIVEMembrane transporters are widely recognized as important determinants of drug disposition and response, generating increasing interest on the…”
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IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm by De Mattia, Elena, Polesel, Jerry, Roncato, Rossana, Labriet, Adrien, Bignucolo, Alessia, Gagno, Sara, Buonadonna, Angela, D'Andrea, Mario, Lévesque, Eric, Jonker, Derek, Couture, Félix, Guillemette, Chantal, Cecchin, Erika, Toffoli, Giuseppe

“…A new paradigm in cancer chemotherapy derives from the interaction between chemotherapeutics, including irinotecan and 5-fluorouracil (5-FU), and the immune…”
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Genotype-Driven Phase I Study of Irinotecan Administered in Combination With Fluorouracil/Leucovorin in Patients With Metastatic Colorectal Cancer by TOFFOLI, Giuseppe, CECCHIN, Erika, BUONADONNA, Arvgela, NOBILI, Stefania, DE PAOLI, Paolo, INNOCENTI, Federico, GASPARINI, Giampiero, D'ANDREA, Mario, AZZARELLO, Giuseppe, BASSO, Umberto, MINI, Enrico, PESSA, Sergio, DE MATTIA, Elena, LO RE, Giovanni

“…PURPOSE We aimed to identify the maximum-tolerated dose (MTD) of irinotecan in patients with cancer with UGT1A1*1/*1 and *1/*28 genotypes. We hypothesize that…”
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The Role of UGT1A128 Polymorphism in the Pharmacodynamics and Pharmacokinetics of Irinotecan in Patients With Metastatic Colorectal Cancer by TOFFOLI, Giuseppe, CECCHIN, Erika, GIUSTO, Mauro, MEDICI, Michele, GAION, Fernando, SANDRI, Paolo, GALLIGIONI, Enzo, BONURA, Salvatore, BOCCALON, Massimo, BIASON, Paola, FRUSTACI, Sergio, CORONA, Giuseppe, RUSSO, Antonio, BUONADONNA, Angela, D'ANDREA, Mario, PASETTO, Lara Maria, PESSA, Sergio, ERRANTE, Domenico, DE PANGHER, Vincenzo

“…UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite of irinotecan. This could increase toxicity with this…”
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The development of platinum compounds and their possible combination by Pasetto, Lara Maria, D’Andrea, Mario Rosario, Brandes, Alba Ariela, Rossi, Elena, Monfardini, Silvio

“…Cisplatin plays a central role in cancer chemotherapy in spite of its toxicity. To circumvent this toxicity and to enhance its therapeutic index a lot of…”
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Association of STAT -3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients by De Mattia, Elena, Cecchin, Erika, Montico, Marcella, Labriet, Adrien, Guillemette, Chantal, Dreussi, Eva, Roncato, Rossana, Bignucolo, Alessia, Buonadonna, Angela, D'Andrea, Mario, Coppola, Luigi, Lonardi, Sara, Lévesque, Eric, Jonker, Derek, Couture, Félix, Toffoli, Giuseppe

“…Pharmacogenomics has largely been applied to the personalization of irinotecan-based treatment, focusing mainly on the study of genetic variants in adsorption,…”
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Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L by Labriet, Adrien, De Mattia, Elena, Cecchin, Erika, Lévesque, Éric, Jonker, Derek, Couture, Félix, Buonadonna, Angela, D'Andrea, Mario, Villeneuve, Lyne, Toffoli, Giuseppe, Guillemette, Chantal

“…Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including…”
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Controlling protected designation of origin of wine by Raman spectroscopy by Mandrile, Luisa, Zeppa, Giuseppe, Giovannozzi, Andrea Mario, Rossi, Andrea Mario

“…•Designation of origin of wines can be controlled through Raman spectroscopy.•Grape cultivar, provenience and ageing time of wines is determined through…”
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A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy by De Mattia, Elena, Dreussi, Eva, Montico, Marcella, Gagno, Sara, Zanusso, Chiara, Quartuccio, Luca, De Vita, Salvatore, Guardascione, Michela, Buonadonna, Angela, D'Andrea, Mario, Pella, Nicoletta, Favaretto, Adolfo, Mini, Enrico, Nobili, Stefania, Romanato, Loredana, Cecchin, Erika, Toffoli, Giuseppe

“…There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of…”
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Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI by De Mattia, Elena, Polesel, Jerry, Roncato, Rossana, Labriet, Adrien, Bignucolo, Alessia, Dreussi, Eva, Romanato, Loredana, Guardascione, Michela, Buonadonna, Angela, D'Andrea, Mario, Lévesque, Eric, Jonker, Derek, Couture, Félix, Guillemette, Chantal, Cecchin, Erika, Toffoli, Giuseppe

“…Nuclear receptors act as mediators of cancer-related inflammation and gene expression. They have a regulatory effect on genes encoding proteins related to drug…”
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