Search Results - "D’Amour, Kevin"

In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus by Suh, Hoonkyo, Consiglio, Antonella, Ray, Jasodhara, Sawai, Toru, D'Amour, Kevin A, Gage, Fred H

“…To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone…”
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Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo by Richardson, Mike, Young, Holly, Kadoya, Kuniko, Baetge, Emmanuel E, Kelly, Olivia G, Carpenter, Melissa K, Smart, Nora G, Bang, Anne G, Eliazer, Susan, D'Amour, Kevin A, Agulnick, Alan D, Kroon, Evert, Martinson, Laura A, Cunningham, Justine

“…Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from…”
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Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells by Baetge, Emmanuel E, D'Amour, Kevin A, Bang, Anne G, Eliazer, Susan, Kelly, Olivia G, Agulnick, Alan D, Smart, Nora G, Moorman, Mark A, Kroon, Evert, Carpenter, Melissa K

“…Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that…”
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Efficient differentiation of human embryonic stem cells to definitive endoderm by Baetge, Emmanuel E, D'Amour, Kevin A, Agulnick, Alan D, Eliazer, Susan, Kelly, Olivia G, Kroon, Evert

“…The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use…”
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Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells by Kelly, Olivia G, Chan, Man Yin, Martinson, Laura A, Kadoya, Kuniko, Ostertag, Traci M, Ross, Kelly G, Richardson, Mike, Carpenter, Melissa K, D'Amour, Kevin A, Kroon, Evert, Moorman, Mark, Baetge, Emmanuel E, Bang, Anne G

“…Kelly et al . describe antibodies for purifying two progenitor populations that arise during the differentiation of human embryonic stem cells to pancreatic…”
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A scalable system for production of functional pancreatic progenitors from human embryonic stem cells by Schulz, Thomas C, Young, Holly Y, Agulnick, Alan D, Babin, M Josephine, Baetge, Emmanuel E, Bang, Anne G, Bhoumik, Anindita, Cepa, Igor, Cesario, Rosemary M, Haakmeester, Carl, Kadoya, Kuniko, Kelly, Jonathan R, Kerr, Justin, Martinson, Laura A, McLean, Amanda B, Moorman, Mark A, Payne, Janice K, Richardson, Mike, Ross, Kelly G, Sherrer, Eric S, Song, Xuehong, Wilson, Alistair Z, Brandon, Eugene P, Green, Chad E, Kroon, Evert J, Kelly, Olivia G, D'Amour, Kevin A, Robins, Allan J

“…Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a…”
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Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3‐Kinase Signaling Is Suppressed by McLean, Amanda B., D'Amour, Kevin A., Jones, Karen L., Krishnamoorthy, Malini, Kulik, Michael J., Reynolds, David M., Sheppard, Alan M., Liu, Huiqing, Xu, Ying, Baetge, Emmanuel E., Dalton, Stephen

“…Human ESCs (hESCs) respond to signals that determine their pluripotency, proliferation, survival, and differentiation status. In this report, we demonstrate…”
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196-LB: Stem Cell–Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness by KEYMEULEN, BART, JACOBS-TULLENEERS-THEVISSEN, DANIEL, KROON, EVERT J., JAIMAN, MANASI S., DANIELS, MARK, WANG, RICHARD, PIPELEERS, DANIEL, D’AMOUR, KEVIN, FOYT, HOWARD L.

“…Patients with T1D exhibit a major loss in beta cell mass, associated with low or undetectable circulating markers of beta cell function. C-peptide serves as a…”
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Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling by Wang, Linlin, Schulz, Thomas C., Sherrer, Eric S., Dauphin, Derek S., Shin, Soojung, Nelson, Angelique M., Ware, Carol B., Zhan, Mei, Song, Chao-Zhong, Chen, Xiaoji, Brimble, Sandii N., McLean, Amanda, Galeano, Maria J., Uhl, Elizabeth W., D'Amour, Kevin A., Chesnut, Jonathan D., Rao, Mahendra S., Blau, C. Anthony, Robins, Allan J.

“…Despite progress in developing defined conditions for human embryonic stem cell (hESC) cultures, little is known about the cell-surface receptors that are…”
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Derivation of insulin-producing cells from human embryonic stem cells by Van Hoof, Dennis, D'Amour, Kevin A, German, Michael S

“…The potential of pluripotent human cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells, to differentiate into any adult…”
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Genetic and Functional Differences between Multipotent Neural and Pluripotent Embryonic Stem Cells by D'Amour, Kevin A., Gage, Fred H.

“…Stem cells (SCs) are functionally defined by their abilities to self-renew and generate differentiated cells. Although much effort has been focused on defining…”
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Cell fusion-independent differentiation of neural stem cells to the endothelial lineage by Gage, Fred H, Wurmser, Andrew E, Nakashima, Kinichi, Summers, Robert G, Toni, Nicolas, D'Amour, Kevin A, Lie, Dieter C

“…Somatic stem cells have been claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticity) that could be induced by…”
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Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D) by HENRY, ROBERT R., PETTUS, JEREMY, WILENSKY, JON, SHAPIRO, A.M. JAMES, SENIOR, PETER A., ROEP, BART, WANG, RICHARD, KROON, EVERT J., SCOTT, MICHAEL, D'AMOUR, KEVIN, FOYT, HOWARD L.

“…VC-01 is a novel cell replacement therapy being developed as a potential long-term diabetes therapy to more effectively control glycemia, reduce hypoglycemia…”
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Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells by Xie, Ruiyu, Everett, Logan J., Lim, Hee-Woong, Patel, Nisha A., Schug, Jonathan, Kroon, Evert, Kelly, Olivia G., Wang, Allen, D’Amour, Kevin A., Robins, Allan J., Won, Kyoung-Jae, Kaestner, Klaus H., Sander, Maike

“…Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains…”
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Aberrant Patterning of Neuromuscular Synapses in Choline Acetyltransferase-Deficient Mice by Brandon, Eugene P, Lin, Weichun, D'Amour, Kevin A, Pizzo, Donald P, Dominguez, Bertha, Sugiura, Yoshie, Thode, Silke, Ko, Chien-Ping, Thal, Leon J, Gage, Fred H, Lee, Kuo-Fen

“…In this study we examined the developmental roles of acetylcholine (ACh) by establishing and analyzing mice lacking choline acetyltransferase (ChAT), the…”
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Choline Transporter 1 Maintains Cholinergic Function in Choline Acetyltransferase Haploinsufficiency by Brandon, Eugene P, Mellott, Tiffany, Pizzo, Donald P, Coufal, Nicole, D'Amour, Kevin A, Gobeske, Kevin, Lortie, Mark, Lopez-Coviella, Ignacio, Berse, Brygida, Thal, Leon J, Gage, Fred H, Blusztajn, Jan Krzysztof

“…Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine (ACh), is thought to be present in kinetic excess in…”
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Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device by Shapiro, A.M. James, Thompson, David, Donner, Thomas W., Bellin, Melena D., Hsueh, Willa, Pettus, Jeremy, Wilensky, Jon, Daniels, Mark, Wang, Richard M., Brandon, Eugene P., Jaiman, Manasi S., Kroon, Evert J., D’Amour, Kevin A., Foyt, Howard L.

“…These preliminary data from an ongoing first-in-human phase 1/2, open-label study provide proof-of-concept that pluripotent stem cell-derived pancreatic…”
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Human parthenogenetic stem cells produce enriched populations of definitive endoderm cells after trichostatin A pretreatment by Turovets, Nikolay, D'Amour, Kevin A., Agapov, Vladimir, Turovets, Irina, Kochetkova, Olga, Janus, Jeffrey, Semechkin, Andrey, Moorman, Mark A., Agapova, Larissa

“…Human parthenogenetic stem cells (hpSC) hold great promise as a source of pluripotent stem cells for cell-based transplantation therapy due to their ethical…”
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Insulin‐Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo by Agulnick, Alan D., Ambruzs, Dana M., Moorman, Mark A., Bhoumik, Anindita, Cesario, Rosemary M., Payne, Janice K., Kelly, Jonathan R., Haakmeester, Carl, Srijemac, Robert, Wilson, Alistair Z., Kerr, Justin, Frazier, Mauro A., Kroon, Evert J., D'Amour, Kevin A.

“…This paper describes a new protocol for producing insulin‐producing cells in vitro that represents another potential cell source for a diabetes cell therapy…”
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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells by Odorico, Jon, Markmann, James, Melton, Douglas, Greenstein, Julia, Hwa, Albert, Nostro, Cristina, Rezania, Alireza, Oberholzer, Jose, Pipeleers, Daniel, Yang, Luhan, Cowan, Chad, Huangfu, Danwei, Egli, Dieter, Ben-David, Uri, Vallier, Ludovic, Grey, Shane T, Tang, Qizhi, Roep, Bart, Ricordi, Camilo, Naji, Ali, Orlando, Giuseppe, Anderson, Daniel G, Poznansky, Mark, Ludwig, Barbara, Tomei, Alice, Greiner, Dale L, Graham, Melanie, Carpenter, Melissa, Migliaccio, Giovanni, D’Amour, Kevin, Hering, Bernhard, Piemonti, Lorenzo, Berney, Thierry, Rickels, Mike, Kay, Thomas, Adams, Ann

“…ABSTRACTBeta cell replacement has the potential to restore euglycemia in patients with insulin-dependent diabetes. Although great progress has been made in…”
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