Search Results - "D’Amore, A."

Disorders of Vascular Permeability by Park-Windhol, Cindy, D'Amore, Patricia A

“…The endothelial barrier maintains vascular and tissue homeostasis and modulates many physiological processes, such as angiogenesis. Vascular barrier integrity…”
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Genome editing abrogates angiogenesis in vivo by Huang, Xionggao, Zhou, Guohong, Wu, Wenyi, Duan, Yajian, Ma, Gaoen, Song, Jingyuan, Xiao, Ru, Vandenberghe, Luk, Zhang, Feng, D’Amore, Patricia A., Lei, Hetian

“…Angiogenesis, in which vascular endothelial growth factor receptor (VEGFR) 2 plays an essential role, is associated with a variety of human diseases including…”
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Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling by Park-Windhol, Cindy, Ng, Yin Shan, Yang, Jinling, Primo, Vincent, Saint-Geniez, Magali, D’Amore, Patricia A.

“…Angiogenesis is central to both normal and pathologic processes. Endothelial cells (ECs) express O-glycoproteins that are believed to play important roles in…”
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IGF2: Epigenetic regulation and role in development and disease by Chao, Wendy, D’Amore, Patricia A

“…Abstract Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted –…”
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VEGFR1 signaling in retinal angiogenesis and microinflammation by Uemura, Akiyoshi, Fruttiger, Marcus, D'Amore, Patricia A., De Falco, Sandro, Joussen, Antonia M., Sennlaub, Florian, Brunck, Lynne R., Johnson, Kristian T., Lambrou, George N., Rittenhouse, Kay D., Langmann, Thomas

“…Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, –C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A…”
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Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing by Maruyama, Kazuichi, Asai, Jun, Ii, Masaaki, Thorne, Tina, Losordo, Douglas W, D'Amore, Patricia A

“…Impaired wound healing is a common complication of diabetes. Although it is well known that both macrophages and blood vessels are critical to wound repair,…”
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essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris by Saint-Geniez, Magali, Kurihara, Tomoki, Sekiyama, Eiichi, Maldonado, Angel E, D'Amore, Patricia A

“…Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris…”
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Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells by Gnanaguru, Gopalan, Choi, Ariel R, Amarnani, Dhanesh, D'Amore, Patricia A

“…Accumulation of oxidized phospholipids/lipoproteins with age is suggested to contribute to the pathogenesis of AMD. We investigated the effect of oxidized LDL…”
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RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis by Bryan, Brad A, Dennstedt, Emily, Mitchell, Dianne C, Walshe, Tony E, Noma, Kensuke, Loureiro, Robyn, Saint-Geniez, Magali, Campaigniac, Jean-Paul, Liao, James K, D'Amore, Patricia A

“…The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2, regulate a number of cellular processes, including cell motility, proliferation, survival,…”
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Survival Benefit and Cost Savings From Compliance With a Simplified 3-Hour Sepsis Bundle in a Series of Prospective, Multisite, Observational Cohorts by Leisman, Daniel E., Doerfler, Martin E., Ward, Mary Frances, Masick, Kevin D., Wie, Benjamin J., Gribben, Jeanie L., Hamilton, Eric, Klein, Zachary, Bianculli, Andrea R., Akerman, Meredith B., D’Angelo, John K., D’Amore, Jason A.

“…OBJECTIVES:To determine mortality and costs associated with adherence to an aggressive, 3-hour sepsis bundle versus noncompliance with greater than or equal to…”
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NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration by Tseng, Wen Allen, Thein, Thuzar, Kinnunen, Kati, Lashkari, Kameran, Gregory, Meredith S, D'Amore, Patricia A, Ksander, Bruce R

“…To evaluate the effect of lysosomal destabilization on NLRP3 inflammasome activation in RPE cells and to investigate the mechanisms by which inflammasome…”
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Forty-year journey of angiogenesis translational research by Cao, Yihai, Arbiser, Jack, D'Amato, Robert J, D'Amore, Patricia A, Ingber, Donald E, Kerbel, Robert, Klagsbrun, Michael, Lim, Sharon, Moses, Marsha A, Zetter, Bruce, Dvorak, Harold, Langer, Robert

“…Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis and that inhibiting this process might be a new strategy for cancer…”
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Association of Fluid Resuscitation Initiation Within 30 Minutes of Severe Sepsis and Septic Shock Recognition With Reduced Mortality and Length of Stay by Leisman, Daniel, BS, Wie, Benjamin, BA, Doerfler, Martin, MD, Bianculli, Andrea, BA, Frances Ward, Mary, RN, MS, Akerman, Meredith, MS, D’Angelo, John K., MD, Zemmel D’Amore, Jason A., MD

“…Study objective We evaluate the association of intravenous fluid resuscitation initiation within 30 minutes of severe sepsis or septic shock identification in…”
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Expression and role of VEGF in the adult retinal pigment epithelium by Ford, Knatokie M, Saint-Geniez, Magali, Walshe, Tony, Zahr, Alisar, D'Amore, Patricia A

“…Despite a lack of active angiogenesis, VEGF is expressed in nearly every adult tissue, and recent evidence suggests that VEGF may serve as a survival factor…”
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Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation by Huang, Xionggao, Zhou, Guohong, Wu, Wenyi, Ma, Gaoen, D'Amore, Patricia A, Mukai, Shizuo, Lei, Hetian

“…Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that…”
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The Role of Shear-Induced Transforming Growth Factor-β Signaling in the Endothelium by Walshe, Tony E, dela Paz, Nathaniel G, D’Amore, Patricia A

“…OBJECTIVE—Vascular endothelial cells (ECs) are continuously exposed to blood flow that contributes to the maintenance of vessel structure and function;…”
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From direct to confocal microscopy for tinea nigra: Time to shift towards in vivo imaging? by Cappilli, S., D'Amore, A., Di Stefani, A.

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Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity by Leblanc, Michelle E., Saez‐Torres, Kahira L., Cano, Issahy, Hu, Zhengping, Saint‐Geniez, Magali, Ng, Yin‐Shan, D'Amore, Patricia A.

“…ABSTRACT We have previously shown that knockdown of endomucin (EMCN), an integral membrane glycocalyx glycoprotein, prevents VEGF‐induced proliferation,…”
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Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration by Bharti, Kapil, den Hollander, Anneke I., Lakkaraju, Aparna, Sinha, Debasish, Williams, David S., Finnemann, Silvia C., Bowes-Rickman, Catherine, Malek, Goldis, D'Amore, Patricia A.

“…Age-related macular degeneration (AMD) is a disease that affects the macula – the central part of the retina. It is a leading cause of irreversible vision loss…”
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Arterial versus venous endothelial cells by dela Paz, Nathaniel G, D'Amore, Patricia A

“…Vascular endothelial cells (ECs) form the inner lining of all blood vessels from the largest artery and veins, viz., the aorta and venae cavae, respectively,…”
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