Search Results - "D’Agostino, Massimo"

PD-L1 Expression Fluctuates Concurrently with Cyclin D in Glioblastoma Cells by Tufano, Martina, D’Arrigo, Paolo, D’Agostino, Massimo, Giordano, Carolina, Marrone, Laura, Cesaro, Elena, Romano, Maria Fiammetta, Romano, Simona

“…Despite Glioblastoma (GBM) frequently expressing programmed cell death ligand-1 (PD-L1), treatment with anti-programmed cell death-1 (PD1) has not yielded…”
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Lysosomal positioning diseases: beyond substrate storage by Scerra, Gianluca, De Pasquale, Valeria, Scarcella, Melania, Caporaso, Maria Gabriella, Pavone, Luigi Michele, D'Agostino, Massimo

“…Lysosomal storage diseases (LSDs) comprise a group of inherited monogenic disorders characterized by lysosomal dysfunctions due to undegraded substrate…”
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Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape by Marrone, Laura, D'Agostino, Massimo, Giordano, Carolina, Giacomo, Valeria DI, Urzini, Simona, Malasomma, Chiara, Gammella, Maria Paola, Tufano, Martina, Romano, Simona, Romano, Maria Fiammetta

“…Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins,…”
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Metabolites Profiling of Melanoma Interstitial Fluids Reveals Uridine Diphosphate as Potent Immune Modulator Capable of Limiting Tumor Growth by Vecchio, Eleonora, Caiazza, Carmen, Mimmi, Selena, Avagliano, Angelica, Iaccino, Enrico, Brusco, Teresa, Nisticò, Nancy, Maisano, Domenico, Aloisio, Annamaria, Quinto, Ileana, Renna, Maurizio, Divisato, Giuseppina, Romano, Simona, Tufano, Martina, D'Agostino, Massimo, Vigliar, Elena, Iaccarino, Antonino, Mignogna, Chiara, Andreozzi, Francesco, Mannino, Gaia Chiara, Spiga, Rosangela, Stornaiuolo, Mariano, Arcucci, Alessandro, Mallardo, Massimo, Fiume, Giuseppe

“…Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites, proteins, and extracellular vesicles secreted by tumor and stromal…”
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Early onset effects of single substrate accumulation recapitulate major features of LSD in patient-derived lysosomes by Scerra, Gianluca, De Pasquale, Valeria, Pavone, Luigi Michele, Caporaso, Maria Gabriella, Mayer, Andreas, Renna, Maurizio, D'Agostino, Massimo

“…Lysosome functions mainly rely on their ability to either degrade substrates or release them into the extracellular space. Lysosomal storage disorders (LSDs)…”
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SNARE ‐mediated membrane fusion arrests at pore expansion to regulate the volume of an organelle by D'Agostino, Massimo, Risselada, Herre Jelger, Endter, Laura J, Comte‐Miserez, Véronique, Mayer, Andreas

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A tethering complex drives the terminal stage of SNARE-dependent membrane fusion by D’Agostino, Massimo, Risselada, Herre Jelger, Lürick, Anna, Ungermann, Christian, Mayer, Andreas

“…Tethering proteins, known to mediate initial recognition and attachment during membrane fusion, are essential for driving the transition from the hemifused…”
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Assay of Lipid Mixing and Fusion Pore Formation in the Fusion of Yeast Vacuoles by D'Agostino, Massimo, Mayer, Andreas

“…Fluorescence de-quenching can be used to analyze membrane lipid mixing during an in vitro fusion reaction. Here we describe a method to measure lipid mixing…”
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N‑Substituted l‑Iminosugars for the Treatment of Sanfilippo Type B Syndrome by De Pasquale, Valeria, Esposito, Anna, Scerra, Gianluca, Scarcella, Melania, Ciampa, Mariangela, Luongo, Antonietta, D’Alonzo, Daniele, Guaragna, Annalisa, D’Agostino, Massimo, Pavone, Luigi Michele

“…Sanfilippo syndrome comprises a group of four genetic diseases due to the lack or decreased activity of enzymes involved in heparan sulfate (HS) catabolism. HS…”
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The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages by Caiazza, Carmen, Brusco, Teresa, D'Alessio, Federica, D'Agostino, Massimo, Avagliano, Angelica, Arcucci, Alessandro, Ambrosino, Concetta, Fiume, Giuseppe, Mallardo, Massimo

“…STING is a transmembrane ER resident protein that was initially described as a regulator of innate immune response triggered by viral DNA and later found to be…”
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Effects of Long-Term Citrate Treatment in the PC3 Prostate Cancer Cell Line by Caiazza, Carmen, D'Agostino, Massimo, Passaro, Fabiana, Faicchia, Deriggio, Mallardo, Massimo, Paladino, Simona, Pierantoni, Giovanna Maria, Tramontano, Donatella

“…Acute administration of a high level of extracellular citrate displays an anti-proliferative effect on both in vitro and in vivo models. However, the long-term…”
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Fusion Pores Live on the Edge by Blokhuis, Edgar M, D’Agostino, Massimo, Mayer, Andreas, Risselada, H. Jelger

“…Biological transmission of vesicular content occurs by opening of a fusion pore. Recent experimental observations have illustrated that fusion pores between…”
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Protocol for labeling and fixation of intact lysosomes with esterified amino acid analogs to assess lysosomal expansion in living eukaryotic cells by Scerra, Gianluca, Caporaso, Maria Gabriella, Renna, Maurizio, D’Agostino, Massimo

“…The lysosomal compartment is a key hub for cell metabolism, and morphological alterations have been described in several pathological conditions. Here, we…”
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Methylmalonic acidemia triggers lysosomal-autophagy dysfunctions by Costanzo, Michele, Cevenini, Armando, Kollipara, Laxmikanth, Caterino, Marianna, Bianco, Sabrina, Pirozzi, Francesca, Scerra, Gianluca, D'Agostino, Massimo, Pavone, Luigi Michele, Sickmann, Albert, Ruoppolo, Margherita

“…Methylmalonic acidemia (MMA) is a rare inborn error of propionate metabolism caused by deficiency of the mitochondrial methylmalonyl-CoA mutase (MUT) enzyme…”
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Metabolic rewiring and autophagy inhibition correct lysosomal storage disease in mucopolysaccharidosis IIIB by Scarcella, Melania, Scerra, Gianluca, Ciampa, Mariangela, Caterino, Marianna, Costanzo, Michele, Rinaldi, Laura, Feliciello, Antonio, Anzilotti, Serenella, Fiorentino, Chiara, Renna, Maurizio, Ruoppolo, Margherita, Pavone, Luigi Michele, D’Agostino, Massimo, De Pasquale, Valeria

“…Mucopolysaccharidoses (MPSs) are lysosomal disorders with neurological involvement for which no cure exists. Here, we show that recombinant NK1 fragment of…”
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An αB-Crystallin Peptide Rescues Compartmentalization and Trafficking Response to Cu Overload of ATP7B-H1069Q, the Most Frequent Cause of Wilson Disease in the Caucasian Population by Allocca, Simona, Ciano, Michela, Ciardulli, Maria Camilla, D'Ambrosio, Chiara, Scaloni, Andrea, Sarnataro, Daniela, Caporaso, Maria Gabriella, D'Agostino, Massimo, Bonatti, Stefano

“…The H1069Q substitution is the most frequent mutation of the Cu transporter ATP7B that causes Wilson disease in the Caucasian population. ATP7B localizes to…”
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A method for the analysis of the oligomerization profile of the Huntington's disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation by Bonavita, Raffaella, Di Martino, Rosaria, Cortone, Giuseppe, Prodomo, Antonello, Di Gennaro, Mariagrazia, Scerra, Gianluca, Panico, Valentino, Nuzzo, Silvia, Salvatore, Marco, Williams, Sarah V, Vitale, Fulvia, Caporaso, Maria Gabriella, D'Agostino, Massimo, Pisani, Francesca M, Fleming, Angeleen, Renna, Maurizio

“…Conformational diseases, such as Alzheimer's, Parkinson's and Huntington's diseases as well as ataxias and fronto-temporal disorders, are part of common class…”
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Steric hindrance of SNARE transmembrane domain organization impairs the hemifusion-to-fusion transition by D'Agostino, Massimo, Risselada, Herre Jelger, Mayer, Andreas

“…SNAREs fuse membranes in several steps. Trans ‐SNARE complexes juxtapose membranes, induce hemifused stalk structures, and open the fusion pore. A recent…”
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Symptoms evolution in children treated with allergen immunotherapy: a real-life pilot study by Milan, Valentina, Simoncini, Daniela, Sepe, Margherita, Agosti, Massimo Agostino

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ER Reorganization is Remarkably Induced in COS-7 Cells Accumulating Transmembrane Protein Receptors Not Competent for Export from the Endoplasmic Reticulum by D’Agostino, Massimo, Crespi, Arianna, Polishchuk, Elena, Generoso, Serena, Martire, Gianluca, Colombo, Sara Francesca, Bonatti, Stefano

“…The newly synthesized mutant L501fsX533 Frizzled-4 form and the alpha3beta4 nicotinic acetylcholine receptor expressed in the absence of nicotine accumulate in…”
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