Search Results - "D’Addio, Suzanne M"

Controlling drug nanoparticle formation by rapid precipitation by D'Addio, Suzanne M., Prud'homme, Robert K.

“…Nanoparticles are a drug delivery platform that can enhance the efficacy of active pharmaceutical ingredients, including poorly-water soluble compounds, ionic…”
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Probing Molecular Packing of Lipid Nanoparticles from 31P Solution and Solid-State NMR by Schroder, Ryan, Dorsey, Phillip J., Vanderburgh, Joe, Xu, Wei, D’Addio, Suzanne M., Klein, Lee, Gindy, Marian, Su, Yongchao

“…Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their efficient delivery of oligonucleotide cargo to host cells. Gaining…”
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In Situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR by Ni, Qing Zhe, Yang, Fengyuan, Can, Thach V, Sergeyev, Ivan V, D’Addio, Suzanne M, Jawla, Sudheer K, Li, Yongjun, Lipert, Maya P, Xu, Wei, Williamson, R. Thomas, Leone, Anthony, Griffin, Robert G, Su, Yongchao

“…A principal advantage of magic angle spinning (MAS) NMR spectroscopy lies in its ability to determine molecular structure in a noninvasive and quantitative…”
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Injectable liposome-containing click hydrogel microparticles for release of macromolecular cargos by Palmese, Luisa L, LeValley, Paige J, Pradhan, Lina, Parsons, Amanda L, Oakey, John S, Abraham, Mathew, D'Addio, Suzanne M, Kloxin, April M, Liang, Yingkai, Kiick, Kristi L

“…Hydrogel microparticles ranging from 0.1-100 μm, referred to as microgels, are attractive for biological applications afforded by their injectability and…”
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A Model Study to Assess Fibrillation and Product Stability to Support Peptide Drug Design by Renawala, Harshil K., Chandrababu, Karthik B., Smith, Katelyn J., D’Addio, Suzanne M., Topp, Elizabeth M.

“…The fibrillation of therapeutic peptides can present significant quality concerns and poses challenges for manufacturing and storage. A fundamental…”
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Molecular Mechanism of Antimicrobial Excipient-Induced Aggregation in Parenteral Formulations of Peptide Therapeutics by Li, Mingyue, Falk, Bradley T., Lu, Xingyu, Schroder, Ryan, Mccoy, Mark, Xu, Wei, Yin, Daniel H., Gindy, Marian E., D’Addio, Suzanne M., Su, Yongchao

“…Antimicrobial preservatives are used as functional excipients in multidose formulations of biological therapeutics to destroy or inhibit the growth of…”
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Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying by D’Addio, Suzanne M., Chan, John Gar Yan, Kwok, Philip Chi Lip, Benson, Bryan R., Prud’homme, Robert K., Chan, Hak-Kim

“…Purpose While most examples of nanoparticle therapeutics have involved parenteral or IV administration, pulmonary delivery is an attractive alternative,…”
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Effects of block copolymer properties on nanocarrier protection from in vivo clearance by D'Addio, Suzanne M., Saad, Walid, Ansell, Steven M., Squiers, John J., Adamson, Douglas H., Herrera-Alonso, Margarita, Wohl, Adam R., Hoye, Thomas R., Macosko, Christopher W., Mayer, Lawrence D., Vauthier, Christine, Prud'homme, Robert K.

“…Drug nanocarrier clearance by the immune system must be minimized to achieve targeted delivery to pathological tissues. There is considerable interest in…”
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Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers by D'Addio, Suzanne M., Baldassano, Steven, Shi, Lei, Cheung, Lila, Adamson, Douglas H., Bruzek, Matthew, Anthony, John E., Laskin, Debra L., Sinko, Patrick J., Prud'homme, Robert K.

“…Treatment of tuberculosis is impaired by poor drug bioavailability, systemic side effects, patient non-compliance, and pathogen resistance to existing…”
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Determining drug release rates of hydrophobic compounds from nanocarriers by D'Addio, Suzanne M., Bukari, Abdallah A., Dawoud, Mohammed, Bunjes, Heike, Rinaldi, Carlos, Prud'homme, Robert K.

“…Obtaining meaningful drug release profiles for drug formulations is essential prior to in vivo testing and for ensuring consistent quality. The release…”
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Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641 by D’Addio, Suzanne M, Reddy, Venkata M, Liu, Ying, Sinko, Patrick J, Einck, Leo, Prud’homme, Robert K

“…Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient…”
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Novel Method for Concentrating and Drying Polymeric Nanoparticles: Hydrogen Bonding Coacervate Precipitation by D’Addio, Suzanne M, Kafka, Concepcion, Akbulut, Mustafa, Beattie, Patrick, Saad, Walid, Herrera, Margarita, Kennedy, Michael T, Prud’homme, Robert K

“…Nanoparticles have significant potential in therapeutic applications to improve the bioavailability and efficacy of active drug compounds. However, the…”
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Inhibition of N-Nitrosamine Formation in Drug Products: A Model Study by Nanda, Kausik K, Tignor, Steven, Clancy, James, Marota, Melanie J, Allain, Leonardo R, D'Addio, Suzanne M

“…Nitrosamines, in the absence of toxicological data, are regarded as potential mutagens and need to be controlled at nanogram levels in drug products. Recent…”
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New and Evolving Techniques for the Characterization of Peptide Therapeutics by D'Addio, Suzanne M, Bothe, Jameson R, Neri, Claudia, Walsh, Paul L, Zhang, Jingtao, Pierson, Elizabeth, Mao, Yun, Gindy, Marian, Leone, Anthony, Templeton, Allen C

“…Advances in technologies related to the design and manufacture of therapeutic peptides have enabled researchers to overcome the biological and technological…”
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Protected Peptide Nanoparticles: Experiments and Brownian Dynamics Simulations of the Energetics of Assembly by Chen, Ting, D’Addio, Suzanne M, Kennedy, Michael T, Swietlow, Aleksander, Kevrekidis, Ioannis G, Panagiotopoulos, Athanassios Z, Prud’homme, Robert K

“…Soluble peptides, susceptible to degradation and clearance in therapeutic applications, have been formulated into protected nanoparticles for the first time…”
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Constant size, variable density aerosol particles by ultrasonic spray freeze drying by D’Addio, Suzanne M., Chan, John Gar Yan, Kwok, Philip Chi Lip, Prud’homme, Robert K., Chan, Hak-Kim

“…This work provides a new understanding of critical process parameters involved in the production of inhalation aerosol particles by ultrasonic spray freeze…”
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Probing Molecular Packing of Lipid Nanoparticles from 31 P Solution and Solid-State NMR by Schroder, Ryan, Dorsey, Phillip J, Vanderburgh, Joe, Xu, Wei, D'Addio, Suzanne M, Klein, Lee, Gindy, Marian, Su, Yongchao

“…Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their efficient delivery of oligonucleotide cargo to host cells. Gaining…”
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Determining drug release rates of hydrophobic compounds from nanocarriers by D'Addio, Suzanne M., Bukari, Abdallah A., Dawoud, Mohammed, Bunjes, Heike, Rinaldi, Carlos, Prud'homme, Robert K.

“…Obtaining meaningful drug release profiles for drug formulations is essential prior to in vivo testing and for ensuring consistent quality. The release…”
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Controlling drug nanoparticle formation by rapid precipitation: NANODRUG PARTICLES AND NANOFORMULATIONS FOR DRUG DELIVERY by D'ADDIO, Suzanne M, PRUD'HOMME, Robert K

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Tuberculosis therapeutics: Engineering of nanomedicinal systems for local delivery of targeted drug cocktails by D'Addio, Suzanne M

“…In this thesis, a multifunctional nanocarrier drug delivery system was investigated and optimized to improve tuberculosis therapy by promoting the…”
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