Search Results - "Dörner, G"

Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life by Dörner, G, Plagemann, A

“…The importance of the intrauterine and neonatal metabolic environment as possible teratogenic determinants of predispositions to diabetes, obesity and…”
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Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams by Plagemann, A, Harder, T, Rake, A, Melchior, K, Rohde, W, Dörner, G

“…Maternal low protein malnutrition during gestation and lactation (LP) is an animal model frequently used for the investigation of long-term deleterious…”
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Observations on the Orexigenic Hypothalamic Neuropeptide Y-System in Neonatally Overfed Weanling Rats by Plagemann, A, Harder, T, Rake, A, Waas, T, Melchior, K, Ziska, T, Rohde, W, Dörner, G

“…Early postnatal overnutrition is a risk factor for obesity in juvenile and adult life. Underlying pathophysiological mechanisms are still unclear. Hypothalamic…”
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Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats by Plagemann, Andreas, Harder, Thomas, Melchior, Kerstin, Rake, Annett, Rohde, Wolfgang, Dörner, Günter

“…WE recently reported on an elevation of neurons expressing the main orexigenic peptide neuropeptide Y (NPY) in the arcuate hypothalamic nucleus (ARC) of…”
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Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8 + T Cells by Dorner, Brigitte G., Dorner, Martin B., Zhou, Xuefei, Opitz, Corinna, Mora, Ahmed, Güttler, Steffen, Hutloff, Andreas, Mages, Hans W., Ranke, Katja, Schaefer, Michael, Jack, Robert S., Henn, Volker, Kroczek, Richard A.

“…The expression of the chemokine receptor XCR1 and the function of its ligand XCL1 (otherwise referred to as ATAC, lymphotactin, or SCM-1) remained elusive to…”
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Highly sensitive sandwich immunoassay and immunochromatographic test for the detection of Clostridial epsilon toxin in complex matrices by Féraudet-Tarisse, Cécile, Mazuet, Christelle, Pauillac, Serge, Krüger, Maren, Lacroux, Caroline, Popoff, Michel R, Dorner, Brigitte G, Andréoletti, Olivier, Plaisance, Marc, Volland, Hervé, Simon, Stéphanie

“…Epsilon toxin is one of the four major toxins of Clostridium perfringens. It is the third most potent clostridial toxin after botulinum and tetanus toxins and…”
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Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1 by Mahrhold, Stefan, Bergström, Tomas, Stern, Daniel, Dorner, Brigitte G, Åstot, Crister, Rummel, Andreas

“…The extraordinary potency of botulinum neurotoxins (BoNTs) is mediated by their high neurospecificity, targeting peripheral cholinergic motoneurons leading to…”
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Glycan Profile and Sequence Variants of Certified Ricin Reference Material and Other Ricin Samples Yield Unique Molecular Signature Features by Josuran, Roland, Wenger, Andreas, Müller, Christian, Kampa, Bettina, Worbs, Sylvia, Dorner, Brigitte G, Gerber, Sabina

“…A certified reference material of ricin (CRM-LS-1) was produced by the EuroBioTox consortium to standardise the analysis of this biotoxin. This study…”
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Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid by Nowakowska, Maria B., Selby, Katja, Przykopanski, Adina, Krüger, Maren, Krez, Nadja, Dorner, Brigitte G., Dorner, Martin B., Jin, Rongsheng, Minton, Nigel P., Rummel, Andreas, Lindström, Miia

“…Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum , cause botulism, a rare but fatal illness affecting humans and…”
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Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes by Garhöfer, G, Zawinka, C, Resch, H, Kothy, P, Schmetterer, L, Dorner, G T

“…Background/aim: Stimulation of the retina with flickering light increases retinal arterial and venous diameters in animals and humans, indicating a tight…”
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Strengthening the United Nations Secretary-General’s Mechanism to an alleged use of bioweapons through a quality-assured laboratory response by Appelt, Sandra, Rohleder, Anna-Maria, Invernizzi, Cédric, Mikulak, Robert, Brinkmann, Annika, Nitsche, Andreas, Krüger, Maren, Dorner, Martin B., Dorner, Brigitte G., Scholz, Holger C., Grunow, Roland

“…The cascade of innovations in biotechnology opens new pathways for biological warfare. The international laboratory network being developed under the UN…”
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Rapid and simultaneous detection of ricin, staphylococcal enterotoxin B and saxitoxin by chemiluminescence-based microarray immunoassay by Szkola, A, Linares, E M, Worbs, S, Dorner, B G, Dietrich, R, Märtlbauer, E, Niessner, R, Seidel, M

“…Simultaneous detection of small and large molecules on microarray immunoassays is a challenge that limits some applications in multiplex analysis. This is the…”
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Flexible upscaling of laboratory PCR testing capacity at the Robert Koch Institute during the SARS-CoV-2 pandemic by Krause, Eva, Michel, Janine, Puyskens, Andreas, Hofmann, Natalie, Rinner, Thomas, Biere, Barbara, Dorner, Brigitte G, Skiba, Martin, Schaade, Lars, Nitsche, Andreas

“…Over the course of the COVID-19 pandemic, laboratories worldwide have been facing an unprecedented increase in demand for PCR testing because of the high…”
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Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype by Kull, Skadi, Schulz, K Melanie, Weisemann, Jasmin, Kirchner, Sebastian, Schreiber, Tanja, Bollenbach, Alexander, Dabrowski, P Wojtek, Nitsche, Andreas, Kalb, Suzanne R, Dorner, Martin B, Barr, John R, Rummel, Andreas, Dorner, Brigitte G

“…Botulism is a severe neurological disease caused by the complex family of botulinum neurotoxins (BoNT). Based on the different serotypes known today, a…”
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Vaccine-induced neutralizing antibodies bind to the H protein of a historical measles virus by Zemella, Anne, Beer, Kerstin, Ramm, Franziska, Wenzel, Dana, Düx, Ariane, Merkel, Kevin, Calvignac-Spencer, Sebastien, Stern, Daniel, Dorner, Martin B., Dorner, Brigitte G., Widulin, Navena, Schnalke, Thomas, Walter, Cornelia, Wolbert, Anne, Schmid, Bernhard G., Mankertz, Annette, Santibanez, Sabine

“…Measles is a highly contagious airborne viral disease. It can lead to serious complications and death and is preventable by vaccination. The live-attenuated…”
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Ricinus communis intoxications in human and veterinary medicine-a summary of real cases by Worbs, Sylvia, Köhler, Kernt, Pauly, Diana, Avondet, Marc-André, Schaer, Martin, Dorner, Martin B, Dorner, Brigitte G

“…Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries but the causative agent remained elusive until 1888…”
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Recognition of a Virus-Encoded Ligand by a Natural Killer Cell Activation Receptor by Hamish R. C. Smith, Heusel, Jonathan W., Mehta, Indira K., Kim, Sungjin, Dorner, Brigitte G., Naidenko, Olga V., Iizuka, Koho, Furukawa, Hiroshi, Beckman, Diana L., Pingel, Jeanette T., Scalzo, Anthony A., Fremont, Daved H., Yokoyama, Wayne M.

“…Natural killer (NK) cells express inhibitory and activation receptors that recognize MHC class I-like molecules on target cells. These receptors may be…”
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Real-time cytotoxicity assay for rapid and sensitive detection of ricin from complex matrices by Pauly, Diana, Worbs, Sylvia, Kirchner, Sebastian, Shatohina, Olena, Dorner, Martin B, Dorner, Brigitte G

“…In the context of a potential bioterrorist attack sensitive and fast detection of functionally active toxins such as ricin from complex matrices is necessary…”
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Increased number of galanin-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats by Plagemann, Andreas, Harder, Thomas, Rake, Annett, Melchior, Kerstin, Rohde, Wolfgang, Dörner, Günter

“…Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is…”
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Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut by Douillard, François P, Derman, Yağmur, Woudstra, Cédric, Selby, Katja, Mäklin, Tommi, Dorner, Martin B, Saxén, Harri, Dorner, Brigitte G, Korkeala, Hannu, Lindström, Miia

“…In early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut…”
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