Pancreatic ductal adenocarcinoma and chronic pancreatitis may be diagnosed by exhaled-breath profiles: a multicenter pilot study

Pancreatic ductal adenocarcinoma and chronic pancreatitis may be diagnosed by exhaled-breath profiles: a multicenter pilot study

The diagnosis of pancreatic adenocarcinoma and chronic pancreatitis often rely on expensive and invasive diagnostic approaches, which are not always discriminative since patients with chronic pancreatitis and pancreatic adenocarcinoma may present with similar symptoms. Volatile organic compounds (VO...

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Bibliographic Details
Published in:Clinical and experimental gastroenterology Vol. 12; pp. 385 - 390
Main Authors: Uslu, H I, Dölle, A R, Dullemen, H M, Aktas, H, Kolkman, J J, Venneman, N G
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-08-2019
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Accuracy
Adenocarcinoma
Alcohol use
Amyotrophic lateral sclerosis
Artificial neural networks
Asthma
Biomarkers
Body mass index
Cancer therapies
Cardiovascular disease
Chemotherapy
chronic pancreatitis
Colonoscopy
Cystic fibrosis
Data analysis
Diabetes
electronic nose
exhaled breath
Gastroenterology
Gender
Inflammatory diseases
Measuring instruments
Medical research
Metabolism
NMR
Nuclear magnetic resonance
Original Research
pancreatic adenocarcinoma
Pancreatic cancer
Pancreatitis
Pollution control
Radiation therapy
Sensors
Spectrum analysis
Studies
Surgery
Thyroid gland
Tuberculosis
VOCs
Volatile organic compounds
Netherlands
pancreatic adenocarcinoma
electronic nose
chronic pancreatitis
exhaled breath
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Summary:The diagnosis of pancreatic adenocarcinoma and chronic pancreatitis often rely on expensive and invasive diagnostic approaches, which are not always discriminative since patients with chronic pancreatitis and pancreatic adenocarcinoma may present with similar symptoms. Volatile organic compounds (VOCs) in expired breath, could be used as a non-invasive diagnostic biological marker for detection of pancreatic pathology. Detection and discrimination of pancreatic pathology with an electronic nose has not yet been reported. The objective of this pilot study was to determine the diagnostic potential of an electronic nose to identify pancreatic adenocarcinoma and chronic pancreatitis by analyzing volatile organic compoundg (VOC) profiles in exhaled air. In a multicenter study, the exhaled air of 56 chronic pancreatitis patients, 29 pancreatic adenocarcinoma patients, and 74 disease controls were analyzed using an electronic nose based on 3 metal oxide sensors (MOS). The measurements were evaluated utilizing an artificial neural network. VOC profiles of chronic pancreatitis patients could be discriminated from disease controls with an accuracy of 0.87 (AUC 0.95, sensitivity 80%, specificity 92%). Also, VOC profiles of patients with pancreatic adenocarcinoma differed from disease controls with an accuracy of 0.83 (AUC 0.87, sensitivity 83%, specificity 82%). Discrimination between chronic pancreatitis and pancreatic adenocarcinoma showed an accuracy of 0.75 (AUC 0.83, sensitivity 83%, specificity 71%). An electronic nose may be a valuable diagnostic tool in diagnosis of pancreatic adenocarcinoma and chronic pancreatitis. The current study shows the potential of an electronic nose for discriminating between chronic pancreatitis, pancreatic adenocarcinoma and healthy controls. The results from this proof-of-concept study warrant external validation in larger cohorts.
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ISSN:1178-7023
1178-7023
DOI:10.2147/CEG.S189102