Search Results - "Díaz‐Nido, J."

Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function by Sánchez, C, Díaz-Nido, J, Avila, J

“…Neurons, the basic information processing units of the nervous system, are characterized by a complex polar morphology which is essential for their function…”
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Pharmacological inhibition of GSK-3 is not strictly correlated with a decrease in tyrosine phosphorylation of residues 216/279 by Simón, D., Benitez, M. J., Gimenez-Cassina, A., Garrido, J. J., Bhat, R. V., Díaz-Nido, J., Wandosell, F.

“…Recent evidence suggests that intramolecular autophosphorylation is responsible for the tyrosine phosphorylation (pY) of residues 279 or 216 of glycogen…”
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Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells by Ulloa, L., Díaz‐Nido, J., Avila, J.

“…Casein kinase II is a multifunctional protein kinase which has been implicated in the regulation of cell growth and differentiation. This enzyme is much more…”
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Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development by AVILA, J, DOMINGUEZ, J, DIAZ-NIDO, J

“…Neuronal morphogenesis is driven by cytoskeletal changes in which microtubules play a leading role. A very heterogeneous group of microtubule-associated…”
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Delivery of the 135kb human frataxin genomic DNA locus gives rise to different frataxin isoforms by Pérez-Luz, S., Gimenez-Cassina, A., Fernández-Frías, I., Wade-Martins, R., Díaz-Nido, J.

“…Friedreich's ataxia (FRDA) is the most common form of hereditary ataxia caused by recessive mutations in the FXN gene. Recent results have indicated the…”
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Regulation of a site-specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neurons by Sánchez, C, Dı́az-Nido, J, Avila, J

“…The phosphorylation state of cytoskeletal proteins, including certain microtubule-associated proteins, may influence the development and plasticity of axons…”
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Delivery of the 135 kb human frataxin genomic DNA locus gives rise to different frataxin isoforms by Pérez-Luz, S, Gimenez-Cassina, A, Fernández-Frías, I, Wade-Martins, R, Díaz-Nido, J

“…Friedreich's ataxia (FRDA) is the most common form of hereditary ataxia caused by recessive mutations in the FXN gene. Recent results have indicated the…”
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A Casein Kinase II-Related Activity Is Involved in Phosphorylation of Microtubule-Associated Protein MAP-1B during Neuroblastoma Cell Differentiation by Díaz-Nido, J., Serrano, L., Méndez, E., Avila, J.

“…A neuroblastoma protein related to the brain microtubule-associated protein, MAP-1B, as determined by immunoprecipitation and coassembly with brain…”
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A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation by Sánchez, S, Jiménez, C, Carrera, A.C, Diaz-Nido, J, Avila, J, Wandosell, F

“…Neuronal differentiation is a complex process in which many different signalling pathways may be involved. An increase in the intracellular levels of cyclic…”
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The inhibition of phosphatidylinositol‐3‐kinase induces neurite retraction and activates GSK3 by Sanchez, S., Sayas, C. L., Lim, F., Diaz‐Nido, J., Avila, J., Wandosell, F.

“…It has been extensively described that neuronal differentiation involves the signalling through neurotrophin receptors to a Ras‐dependent mitogen‐activated…”
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Tubulin Phosphorylation by Casein Kinase II Is Similar to That Found in vivo by Serrano, L., Díaz-Nido, J., Wandosell, F., Avila, J.

“…Purified brain tubulin subjected to an exhaustive phosphatase treatment can be rephosphorylated by casein kinase II. This phosphorylation takes place mainly on…”
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Addition of protease inhibitors to culture medium of neuroblastoma cells induces both neurite outgrowth and phosphorylation of microtubule-associated protein MAP-1B by DIAZ-NIDO, J, ARMAS-PORTELA, R, AVILA, J

“…The addition of two synthetic peptides with antiprotease activity to the culture medium of mouse neuroblastoma cells results in the promotion of neurite…”
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Increase in cytoplasmic casein kinase II-type activity accompanies neurite outgrowth after DNA synthesis inhibition in NIA-103 neuroblastoma cells by Díaz-Nido, J, Armas-Portela, R, Avila, J

“…Whereas cells from most clonal lines derived from the murine neuroblastoma C1300 tumor can be induced to differentiate by serum withdrawal from culture medium,…”
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Characterization of proteins immunologically related to brain microtubule-associated protein MAP-1B in non-neural cells by DIAZ-NIDO, J, AVILA, J

“…Brain microtubule-associated protein MAP-1 is composed of at least two polypeptides, MAP-1A and MAP-1B, which are among the main components of the neural…”
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Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture by Moreno‐Flores, M. T., Martín‐Aparicio, E., Martín‐Bermejo, M. J., Agudo, M., McMahon, S., Ávila, J., Díaz‐Nido, J., Wandosell, F.

“…Semaphorins (sema) constitute a family of molecules sharing a common extracellular domain (semaphorin domain). This family includes several types of secreted…”
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Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain by Correas, I, Diaz-Nido, J, Avila, J

“…We have analyzed the in vitro phosphorylation of tau protein by Ca2+/calmodulin-dependent protein kinase, casein kinase II, and proline-directed…”
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Heterogeneity in the phosphorylation of microtubule-associated protein MAP1B during rat brain development by Ulloa, L, Avila, J, Díaz-Nido, J

“…The patterns of isoforms and of immunoreactivity of the microtubule-associated protein MAP1B toward a panel of antibodies to phosphorylation-sensitive epitopes…”
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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease by Ledesma, M.D., Correas, I., Avila, J., Diaz-Nido, J.

“…Brain tau protein is phosphorylated in vitro by cdc2 and MAP2 kinases, obtained through immunoaffinity purification from rat brain extracts. The…”
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Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector by Gimenez-Cassina, A, Wade-Martins, R, Gomez-Sebastian, S, Corona, J-C, Lim, F, Diaz-Nido, J

“…Novel gene-based therapies for disease will depend in many cases on long-term persistent transgene expression. To develop gene therapy strategies for…”
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Variations in in vivo phosphorylation at the proline-rich domain of the microtubule-associated protein 2 (MAP2) during rat brain development by Sánchez, C, Díaz-Nido, J, Avila, J

“…Microtubule-associated protein 2 (MAP2) is an in vitro substrate for MAP kinase. Part of the phosphorylation occurs at the C-terminal microtubule-binding…”
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