Search Results - "Dévédec, Sylvia Le"

A Red‐Light‐Activated Ruthenium‐Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells by Lameijer, Lucien N., Ernst, Daniël, Hopkins, Samantha L., Meijer, Michael S., Askes, Sven H. C., Le Dévédec, Sylvia E., Bonnet, Sylvestre

“…We describe two water‐soluble ruthenium complexes, [1]Cl2 and [2]Cl2, that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase…”
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Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model by van Rixel, Vincent H. S, Ramu, Vadde, Auyeung, Austin B, Beztsinna, Nataliia, Leger, David Y, Lameijer, Lucien N, Hilt, Stan T, Le Dévédec, Sylvia E, Yildiz, Tugba, Betancourt, Tania, Gildner, M. Brenton, Hudnall, Todd W, Sol, Vincent, Liagre, Bertrand, Kornienko, Alexander, Bonnet, Sylvestre

“…Marine alkaloid rigidins are cytotoxic compounds known to kill cancer cells at nanomolar concentrations by targeting the microtubule network. Here, a rigidin…”
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Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors by Zhang, Liyan, Wang, Peiyuan, Zhou, Xue-Quan, Bretin, Ludovic, Zeng, Xiaolong, Husiev, Yurii, Polanco, Ehider A., Zhao, Gangyin, Wijaya, Lukas S., Biver, Tarita, Le Dévédec, Sylvia E., Sun, Wen, Bonnet, Sylvestre

“…To investigate the potential of tumor-targeting photoactivated chemotherapy, a chiral ruthenium-based anticancer warhead, Λ/Δ-[Ru­(Ph2phen)2(OH2)2]2+, was…”
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Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis by Liu, Sijia, González-Prieto, Román, Zhang, Mengdi, Geurink, Paul P, Kooij, Raymond, Iyengar, Prasanna Vasudevan, van Dinther, Maarten, Bos, Erik, Zhang, Xiaobing, Le Dévédec, Sylvia E, van de Water, Bob, Koning, Roman I, Zhu, Hong-Jian, Mesker, Wilma E, Vertegaal, Alfred C O, Ovaa, Huib, Zhang, Long, Martens, John W M, Ten Dijke, Peter

“…Therapies directed to specific molecular targets are still unmet for patients with triple-negative breast cancer (TNBC). Deubiquitinases (DUB) are emerging…”
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Oxygen-Dependent Interactions between the Ruthenium Cage and the Photoreleased Inhibitor in NAMPT-Targeted Photoactivated Chemotherapy by Abyar, Selda, Huang, Luojiao, Husiev, Yurii, Bretin, Ludovic, Chau, Bobby, Ramu, Vadde, Wildeman, Jacob Hendricus, Belfor, Kimberley, Wijaya, Lukas S., van der Noord, Vera E., Harms, Amy C., Siegler, Maxime A., Le Dévédec, Sylvia E., Bonnet, Sylvestre

“…Photoactivated chemotherapy agents form a new branch of physically targeted anticancer agents with potentially lower systemic side effects for patients. On the…”
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Red‐Light Activation of a Microtubule Polymerization Inhibitor via Amide Functionalization of the Ruthenium Photocage by Bretin, Ludovic, Husiev, Yurii, Ramu, Vadde, Zhang, Liyan, Hakkennes, Matthijs, Abyar, Selda, Johns, Andrew C., Le Dévédec, Sylvia E., Betancourt, Tania, Kornienko, Alexander, Bonnet, Sylvestre

“…Photoactivated chemotherapy (PACT) is a promising cancer treatment modality that kills cancer cells via photochemical uncaging of a cytotoxic drug. Most…”
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A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration by Yizhak, Keren, Le Dévédec, Sylvia E, Rogkoti, Vasiliki Maria, Baenke, Franziska, de Boer, Vincent C, Frezza, Christian, Schulze, Almut, van de Water, Bob, Ruppin, Eytan

“…Over the last decade, the field of cancer metabolism has mainly focused on studying the role of tumorigenic metabolic rewiring in supporting cancer…”
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Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant by van Roosmalen, Wies, Le Dévédec, Sylvia E, Golani, Ofra, Smid, Marcel, Pulyakhina, Irina, Timmermans, Annemieke M, Look, Maxime P, Zi, Di, Pont, Chantal, de Graauw, Marjo, Naffar-Abu-Amara, Suha, Kirsanova, Catherine, Rustici, Gabriella, Hoen, Peter A C 't, Martens, John W M, Foekens, John A, Geiger, Benjamin, van de Water, Bob

“…Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion…”
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Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(II) light-switch complex by Ramu, Vadde, Wijaya, Lukas S, Beztsinna, Nataliia, Van de Griend, Corjan, van de Water, Bob, Bonnet, Sylvestre, Le Dévédec, Sylvia E

“…The famous ''light-switch'' ruthenium complex [Ru(bpy) (dppz)](PF ) (1) has been long known for its DNA binding properties . However, the biological utility of…”
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Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy by Koedoot, Esmee, Wolters, Liesanne, Smid, Marcel, Stoilov, Peter, Burger, Gerhard A., Herpers, Bram, Yan, Kuan, Price, Leo S., Martens, John W. M., Le Dévédec, Sylvia E., van de Water, Bob

“…Screening for effective candidate drugs for breast cancer has shifted from two-dimensional (2D) to three-dimensional (3D) cultures. Here we systematically…”
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Lipidomic profiling of triple-negative breast cancer cells reveals distinct metabolic signatures associated with EpCAM expression by Huang, Xiaoyue, Di, Xinyu, Zuiderwijk, Melissa Celine, Zhang, Lu, Leegwater, Hanneke, Davidse, Sam, Kindt, Alida, Harms, Amy, Hankemeier, Thomas, Le Dévédec, Sylvia E., Ali, Ahmed

“…Lipid metabolism is essential at all stages of cancer progression, particularly for triple-negative breast cancer (TNBC) the deadliest cancer subtype for women…”
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Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes by Koedoot, Esmee, Fokkelman, Michiel, Rogkoti, Vasiliki-Maria, Smid, Marcel, van de Sandt, Iris, de Bont, Hans, Pont, Chantal, Klip, Janna E., Wink, Steven, Timmermans, Mieke A., Wiemer, Erik A. C., Stoilov, Peter, Foekens, John A., Le Dévédec, Sylvia E., Martens, John W. M., van de Water, Bob

“…Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell…”
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Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer by Yizhak, Keren, Gaude, Edoardo, Le Dévédec, Sylvia, Waldman, Yedael Y, Stein, Gideon Y, van de Water, Bob, Frezza, Christian, Ruppin, Eytan

“…Utilizing molecular data to derive functional physiological models tailored for specific cancer cells can facilitate the use of individually tailored…”
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A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A1 Receptor Using an Electrophilic Covalent Probe by Beerkens, Bert L. H., Koç, Çağla, Liu, Rongfang, Florea, Bogdan I., Le Dévédec, Sylvia E., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

“…G protein-coupled receptors (GPCRs) have been known for decades as attractive drug targets. This has led to the development and approval of many ligands…”
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Single-cell metabolomics by mass spectrometry: ready for primetime? by Zhang, Congrou, Le Dévédec, Sylvia E, Ali, Ahmed, Hankemeier, Thomas

“…Single-cell metabolomics (SCMs) is a powerful tool for studying cellular heterogeneity by providing insight into the differences between individual cells. With…”
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Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer by Dekker, Yasmin, Le Dévédec, Sylvia E, Danen, Erik H. J, Liu, Qiuyu

“…Even though breast cancer is the most diagnosed cancer among women, treatments are not always successful in preventing its progression. Recent studies suggest…”
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Development of an Affinity-Based Probe to Profile Endogenous Human Adenosine A3 Receptor Expression by Beerkens, Bert L. H., Snijders, Inge M., Snoeck, Joep, Liu, Rongfang, Tool, Anton T. J., Le Dévédec, Sylvia E., Jespers, Willem, Kuijpers, Taco W., van Westen, Gerard J.P., Heitman, Laura H., IJzerman, Adriaan P., van der Es, Daan

“…The adenosine A3 receptor (A3AR) is a G protein-coupled receptor (GPCR) that exerts immunomodulatory effects in pathophysiological conditions such as…”
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A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury by Wijaya, Lukas S, Gabor, Attila, Pot, Iris E, van de Have, Luca, Saez-Rodriguez, Julio, Stevens, James L, Le Dévédec, Sylvia E, Callegaro, Giulia, van de Water, Bob

“…Abstract Drug-induced liver injury (DILI) remains the main reason for drug development attritions largely due to poor mechanistic understanding. Toxicogenomic…”
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Co-regulated gene expression of splicing factors as drivers of cancer progression by Koedoot, Esmee, Smid, Marcel, Foekens, John A., Martens, John W. M., Le Dévédec, Sylvia E., van de Water, Bob

“…Splicing factors (SFs) act in dynamic macromolecular complexes to modulate RNA processing. To understand the complex role of SFs in cancer progression, we…”
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Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages by Snijders, Kirsten E., Fehér, Anita, Táncos, Zsuzsanna, Bock, István, Téglási, Annamária, van den Berk, Linda, Niemeijer, Marije, Bouwman, Peter, Le Dévédec, Sylvia E., Moné, Martijn J., Van Rossom, Rob, Kumar, Manoj, Wilmes, Anja, Jennings, Paul, Verfaillie, Catherine M., Kobolák, Julianna, ter Braak, Bas, Dinnyés, András, van de Water, Bob

“…Tagging of endogenous stress response genes can provide valuable in vitro models for chemical safety assessment. Here, we present the generation and…”
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