Search Results - "Décosterd, L.A."

G.P.105 by Dorchies, O.M, Ismail, H.M, Tardy, S, Reutenauer-Patte, J, Dahmane, E, Décosterd, L.A, Picard, D, Ruegg, U.T, Scapozza, L

“…We are investigating the effects of selective estrogen receptor modulators (SERMs) in mdx5Cv dystrophic mice (Dys), a model for Duchenne muscular dystrophy…”
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Therapeutic Drug Monitoring of the new targeted anticancer agents imatinib, nilotinib, dasatinib, sunitinib, sorafenib and lapatinib by LC tandem mass spectrometry by Haouala, A., Zanolari, B., Rochat, B., Montemurro, M., Zaman, K., Duchosal, M.A., Ris, H.B., Leyvraz, S., Widmer, N., Decosterd, L.A.

“…The treatment of some cancer patients has shifted from traditional, non-specific cytotoxic chemotherapy to chronic treatment with molecular targeted therapies…”
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PP281—Intravenous streptomycin dosing regimen in a patient undergoing hemodialysis: Plasma level monitoring and pharmacokinetic simulation by Chtioui, H, Zbinden, D, Manuel, O, Entenza, J, Decosterd, L.A, Buclin, T

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OC014—Clinical Usefulness Of Therapeutic Concentration Monitoring For Imatinib Dosage Individualization: Results From The Randomized Controlled I-Come Trial by Gotta, V, Widmer, N, Decosterd, L.A, Chalandon, Y, Heim, D, Benz, R, Gregor, M, Leoncini-Franscini, L, Baerlocher, G, Duchosal, M, Csajka, C, Buclin, T

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Determination of aciclovir and ganciclovir in human plasma by liquid chromatography–spectrofluorimetric detection and stability studies in blood samples by Perrottet, N., Beguin, A., Meylan, P., Pascual, M., Manuel, O., Buclin, T., Biollaz, J., Decosterd, L.A.

“…A sensitive HPLC method has been developed for the assay of aciclovir and ganciclovir in human plasma, by HPLC coupled with spectrofluorimetric detection…”
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Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz by high-performance liquid chromatography after solid-phase extraction by Marzolini, C, Telenti, A, Buclin, T, Biollaz, J, Decosterd, L.A

“…As part of an on-going study on the suitability of a formal therapeutic drug monitoring (TDM) of antiviral drugs for improving the management of HIV infection,…”
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Tyrosine kinase inhibitors concentration monitoring in chronic myeloid leukemia by Widmer, N, Gotta, V, Haouala, A, Decosterd, L.A

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Determination of imatinib (Gleevec ®) in human plasma by solid-phase extraction–liquid chromatography–ultraviolet absorbance detection by Widmer, N, Béguin, A, Rochat, B, Buclin, T, Kovacsovics, T, Duchosal, M.A, Leyvraz, S, Rosselet, A, Biollaz, J, Decosterd, L.A

“…A sensitive HPLC method has been developed for the assay of imatinib in human plasma, by off-line solid-phase extraction followed by HPLC coupled with UV-Diode…”
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Lipid and lipoprotein profile in HIV-infected patients treated with lopinavir/ritonavir as a component of the first combination antiretroviral therapy by Magenta, L, Dell-Kuster, S, Richter, W O, Young, J, Hasse, B, Flepp, M, Hirschel, B, Vernazza, P, Evison, J, Cavassini, M, Decosterd, L A, Bucher, H C, Bernasconi, E

“…We characterized lipid and lipoprotein changes associated with a lopinavir/ritonavir-containing regimen. We enrolled previously antiretroviral-naive patients…”
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G.P.105: Preclinical evaluation of tamoxifen and other selective estrogen receptor modulators in mdx5Cv dystrophic mice by Dorchies, O.M., Ismail, H.M., Tardy, S., Reutenauer-Patte, J., Dahmane, E., Décosterd, L.A., Picard, D., Ruegg, U.T., Scapozza, L.

“…We are investigating the effects of selective estrogen receptor modulators (SERMs) in mdx5Cv dystrophic mice (Dys), a model for Duchenne muscular dystrophy…”
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The emerging role of multiplex tandem mass spectrometry analysis for therapeutic drug monitoring and personalized medicine by Decosterd, L.A., Widmer, N., André, P., Aouri, M., Buclin, T.

“…•LC-MS/MS has changed the way drugs are assayed for Therapeutic Drug Monitoring (TDM).•TDM implies the measurement of drug blood level followed by dosage…”
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Simultaneous Determination of Deoxyribonucleoside in the Presence of Ribonucleoside Triphosphates in Human Carcinoma Cells by High-Performance Liquid Chromatography by Decosterd, L.A., Cottin, E., Chen, X., Lejeune, F., Mirimanoff, R.O., Biollaz, J., Coucke, P.A.

“…Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in cells by HPLC is an analytical challenge since the concentration of dNTP…”
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Validation and clinical application of a multiplex high performance liquid chromatography – tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections by Decosterd, L.A., Mercier, T., Ternon, B., Cruchon, S., Guignard, N., Lahrichi, S., Pesse, B., Rochat, B., Burger, R., Lamoth, F., Pagani, J.-L., Eggimann, P., Csajka, C., Choong, E., Buclin, T., Widmer, N., André, P., Marchetti, O.

“…•Robust HPLC-MS/MS quantification of plasma levels of 12 daily-used antibiotics.•Directly covering the entire clinically relevant ranges of…”
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Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update by Briki, M., Murisier, A., Guidi, M., Seydoux, C., Buclin, T., Marzolini, C., Girardin, F.R., Thoma, Y., Carrara, S., Choong, E., Decosterd, L.A.

“…•Cytotoxic anticancer drugs are increasingly recognized to be valid candidates for therapeutic drug monitoring (TDM).•Numerous LC-MS/MS methods have been…”
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A battery of tandem mass spectrometry assays with stable isotope-dilution for the quantification of 15 anti-tuberculosis drugs and two metabolites in patients with susceptible-, multidrug-resistant- and extensively drug-resistant tuberculosis by Mercier, T., Desfontaine, V., Cruchon, S., Da Silva Pereira Clara, J.A., Briki, M., Mazza-Stalder, J., Kajkus, A., Burger, R., Suttels, V., Buclin, T., Opota, O., Koehler, N., Sanchez Carballo, P.M., Lange, C., André, P., Decosterd, L.A., Choong, E.

“…•Multiplex LC-MS/MS methods for major drugs against susceptible and MDR-tuberculosis.•Use of stable isotopically labelled Internal Standards for all…”
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Corrigendum to “Validation and clinical application of a multiplex high performance liquid chromatography – Tandem mass spectrometry assay for the monitoring of plasma concentrations of 12 antibiotics in patients with severe bacterial infections” [J. Chromatogr. B 1157 (2020) 122160] by Decosterd, L.A., Mercier, T., Ternon, B., Cruchon, S., Guignard, N., Lahrichi, S., Pesse, B., Rochat, B., Burger, R., Lamoth, F., Pagani, J.-L., Eggimann, P., Csajka, C., Choong, E., Buclin, T., Widmer, N., André, P., Marchetti, O.

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A simple, robust and rapid approach to detect carbapenemases in Gram-negative isolates by MALDI-TOF mass spectrometry: validation with triple quadripole tandem mass spectrometry, microarray and PCR by Vogne, C., Prod'hom, G., Jaton, K., Decosterd, L.A., Greub, G.

“…Carbapenemases should be accurately and rapidly detected, given their possible epidemiological spread and their impact on treatment options. Here, we developed…”
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A single LC–tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma by Hodel, E.M., Zanolari, B., Mercier, T., Biollaz, J., Keiser, J., Olliaro, P., Genton, B., Decosterd, L.A.

“…Among the various determinants of treatment response, the achievement of sufficient blood levels is essential for curing malaria. For helping us at improving…”
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A LC–tandem MS assay for the simultaneous measurement of new antiretroviral agents: Raltegravir, maraviroc, darunavir, and etravirine by Fayet, A., Béguin, A., Zanolari, B., Cruchon, S., Guignard, N., Telenti, A., Cavassini, M., Günthard, H.F., Buclin, T., Biollaz, J., Rochat, B., Decosterd, L.A.

“…Raltegravir (RAL), maraviroc (MVC), darunavir (DRV), and etravirine (ETV) are new antiretroviral agents with significant potential for drug interactions. This…”
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Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry by COLOMBO, S, BEGUIN, A, TELENTI, A, BIOLLAZ, J, BUCLIN, T, ROCHAT, B, DECOSTERD, L. A

“…A sensitive and accurate liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the intracellular determination of nine antiretroviral drugs in…”
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