Search Results - "Dätwyler, Philipp"

Selective Inhibitors of Human Neuraminidase 3 by Guo, Tianlin, Dätwyler, Philipp, Demina, Ekaterina, Richards, Michele R, Ge, Peng, Zou, Chunxia, Zheng, Ruixiang, Fougerat, Anne, Pshezhetsky, Alexey V, Ernst, Beat, Cairo, Christopher W

“…Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research…”
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Improvement of Aglycone π‐Stacking Yields Nanomolar to Sub‐nanomolar FimH Antagonists by Schönemann, Wojciech, Cramer, Jonathan, Mühlethaler, Tobias, Fiege, Brigitte, Silbermann, Marleen, Rabbani, Said, Dätwyler, Philipp, Zihlmann, Pascal, Jakob, Roman P., Sager, Christoph P., Smieško, Martin, Schwardt, Oliver, Maier, Timm, Ernst, Beat

“…Antimicrobial resistance has become a serious concern for the treatment of urinary tract infections. In this context, an anti‐adhesive approach targeting FimH,…”
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Prodruggability of carbohydrates — oral FimH antagonists by Schönemann, Wojciech, Kleeb, Simon, Dätwyler, Philipp, Schwardt, Oliver, Ernst, Beat

“…The bacterial lectin FimH is a promising therapeutic target for the nonantibiotic prevention and treatment of urinary tract infections. In this communication,…”
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells by de Matos, Ana M., Martins, Alice, Man, Teresa, Evans, David, Walter, Magnus, Oliveira, Maria Conceição, López, Óscar, Fernandez-Bolaños, José G., Dätwyler, Philipp, Ernst, Beat, Macedo, M. Paula, Contino, Marialessandra, Colabufo, Nicola A., Rauter, Amélia P.

“…With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue…”
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Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer’s Disease by de Matos, Ana M, Blázquez-Sánchez, M. Teresa, Bento-Oliveira, Andreia, de Almeida, Rodrigo F. M, Nunes, Rafael, Lopes, Pedro E. M, Machuqueiro, Miguel, Cristóvão, Joana S, Gomes, Cláudio M, Souza, Cleide S, El Idrissi, Imane G, Colabufo, Nicola A, Diniz, Ana, Marcelo, Filipa, Oliveira, M. Conceição, López, Óscar, Fernandez-Bolaños, José G, Dätwyler, Philipp, Ernst, Beat, Ning, Ke, Garwood, Claire, Chen, Beining, Rauter, Amélia P

“…Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer’s disease, and diabetes-induced dementia, there are no…”
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Strengthening an Intramolecular Non‐Classical Hydrogen Bond to Get in Shape for Binding by Varga, Norbert, Smieško, Martin, Jiang, Xiaohua, Jakob, Roman P., Wagner, Beatrice, Mühlethaler, Tobias, Dätwyler, Philipp, Zihlmann, Pascal, Rabbani, Said, Maier, Timm, Schwardt, Oliver, Ernst, Beat

“…In this research article, we report on the strengthening of a non‐classical hydrogen bond (C−H⋅⋅⋅O) by introducing electron withdrawing groups at the carbon…”
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Activities of N,N'-Diarylurea MMV665852 analogs against Schistosoma mansoni by Cowan, Noemi, Dätwyler, Philipp, Ernst, Beat, Wang, Chunkai, Vennerstrom, Jonathan L, Spangenberg, Thomas, Keiser, Jennifer

“…There is an unmet need to discover and develop novel antischistosomal drugs. As exemplified by MMV665852, N,N'-diarylureas have recently emerged as a promising…”
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Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties by Dätwyler, Philipp, Jiang, Xiaohua, Wagner, Beatrice, Varga, Norbert, Mühlethaler, Tobias, Hostettler, Katja, Rabbani, Said, Schwardt, Oliver, Ernst, Beat

“…Because of their large polar surface area, carbohydrates often exhibit insufficient pharmacokinetic properties. Specifically, the carboxylic acid function of…”
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Strengthening an Intramolecular Non‐Classical Hydrogen Bond to Get in Shape for Binding by Varga, Norbert, Smieško, Martin, Jiang, Xiaohua, Jakob, Roman P., Wagner, Beatrice, Mühlethaler, Tobias, Dätwyler, Philipp, Zihlmann, Pascal, Rabbani, Said, Maier, Timm, Schwardt, Oliver, Ernst, Beat

“…In this research article, we report on the strengthening of a non‐classical hydrogen bond (C−H⋅⋅⋅O) by introducing electron withdrawing groups at the carbon…”
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Front Cover: Improvement of Aglycone π‐Stacking Yields Nanomolar to Sub‐nanomolar FimH Antagonists (ChemMedChem 7/2019) by Schönemann, Wojciech, Cramer, Jonathan, Mühlethaler, Tobias, Fiege, Brigitte, Silbermann, Marleen, Rabbani, Said, Dätwyler, Philipp, Zihlmann, Pascal, Jakob, Roman P., Sager, Christoph P., Smieško, Martin, Schwardt, Oliver, Maier, Timm, Ernst, Beat

“…The Front Cover illustrates the adherence of uropathogenic E. coli to the bladder epithelium, depicting the initial step of a urinary tract infection (UTI)…”
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H 2 O 2 - and Aβ 1-42 -Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells by de Matos, Ana M, Martins, Alice, Man, Teresa, Evans, David, Walter, Magnus, Oliveira, Maria Conceição, López, Óscar, Fernandez-Bolaños, José G, Dätwyler, Philipp, Ernst, Beat, Macedo, M Paula, Contino, Marialessandra, Colabufo, Nicola A, Rauter, Amélia P

“…With the lack of available drugs able to prevent the progression of Alzheimer's disease (AD), the discovery of new neuroprotective treatments able to rescue…”
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