Search Results - "D'apice, Anthony J. F."

Deficiency or Inhibition of CD73 Protects in Mild Kidney Ischemia-Reperfusion Injury by RAJAKUMAR, Siddharth V, BO LU, CRIKIS, Sandra, ROBSON, Simon C, D'APICE, Anthony J. F, COWAN, Peter J, DWYER, Karen M

“…Adenosine agonists are protective in numerous models of ischemia-reperfusion injury (IRI). Pericellular adenosine is generated by the hydrolysis of…”
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The transgenic expression of human CD39 on murine islets inhibits clotting of human blood by INVERARDI, Luca, RICORDI, Camillo, DWYER, Karen M, MYSORE, Tharun B, CRIKIS, Sandra, ROBSON, Simon C, NANDURKAR, Harshal, COWAN, Peter J, D'APICE, Anthony J. F

“…Platelet activation is believed to play an important role in the triggering of thrombosis of human blood by pig islets. We used a transgenic mouse model to…”
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The Impact of Purinergic Signaling on Renal Ischemia-Reperfusion Injury by BO LU, RAJAKUMAR, Siddharth V, ROBSON, Simon C, LEE, Eddy K. F, CRIKIS, Sandra, D'APICE, Anthony J. F, COWAN, Peter J, DWYER, Karen M

“…Adenosine provides renovascular protection in mouse models of ischemia-reperfusion injury (I/RI) through purinergic members of the G protein-coupled receptor…”
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bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila by Sansom, Fiona M, Newton, Hayley J, Crikis, Sandra, Cianciotto, Nicholas P, Cowan, Peter J, d'Apice, Anthony J.F, Hartland, Elizabeth L

“…As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that do not mature into…”
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Versatile co-expression of graft-protective proteins using 2A-linked cassettes by Fisicaro, Nella, Londrigan, Sarah L., Brady, Jamie L., Salvaris, Evelyn, Nottle, Mark B., O'Connell, Philip J., Robson, Simon C., d'Apice, Anthony J. F., Lew, Andrew M., Cowan, Peter J.

“…Fisicaro N, Londrigan SL, Brady JL, Salvaris E, Nottle MB, O’Connell PJ, Robson SC, d’Apice AJF, Lew AM, Cowan PJ. Versatile co‐expression of graft‐protective…”
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Recombinant pig TFPI efficiently regulates human tissue factor pathways by Lee, K. F. Eddy, Salvaris, Evelyn J., Roussel, Jean-Christian, Robson, Simon C., D'Apice, Anthony J. F., Cowan, Peter J.

“…:  Rejected pig‐to‐primate organ xenografts almost invariably exhibit significant microvascular thrombosis, believed to be due in part to several molecular…”
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First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses by Naso, Filippo, Gandaglia, Alessandro, Bottio, Tomaso, Tarzia, Vincenzo, Nottle, Mark B., d'Apice, Anthony J. F., Cowan, Peter J., Cozzi, Emmanuele, Galli, Cesare, Lagutina, Irina, Lazzari, Giovanna, Iop, Laura, Spina, Michele, Gerosa, Gino

“…Background Glutaraldehyde fixation does not guarantee complete tissue biocompatibility in current clinical bioprosthetic heart valves (BHVs). Particularly,…”
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Gene-modified pigs by D'Apice, Anthony J. F., Cowan, Peter J.

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The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice by CHIA, Joanne S. J, McRAE, Jennifer L, COWAN, Peter J, DWYER, Karen M, THOMAS, Helen E, FYNCH, Stacey, ELKERBOUT, Lorraine, HILL, Prue, MURRAY-SEGAL, Lisa, ROBSON, Simon C, CHEN, Jiang-Fan, D'APICE, Anthony J. F

“…Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors…”
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Xenotransplantation: The next generation of engineered animals by d'Apice, Anthony J.F, Cowan, Peter J

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Transgenic swine: Expression of human CD39 protects against myocardial injury by Wheeler, Debra G, Joseph, Matthew E, Mahamud, Shouvik D, Aurand, William L, Mohler, Peter J, Pompili, Vincent J, Dwyer, Karen M, Nottle, Mark B, Harrison, Sharon J, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Abstract CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5′-nucleotidase…”
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Ectonucleotide Triphosphate Diphosphohydrolase-1 (CD39) Mediates Resistance to Occlusive Arterial Thrombus Formation after Vascular Injury in Mice by Huttinger, Zachary M, Milks, Michael W, Nickoli, Michael S, Aurand, William L, Long, Lawrence C, Wheeler, Debra G, Dwyer, Karen M, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of…”
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Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors by Chen, Yan, Stewart, John M., Gunthart, Mirja, Hawthorne, Wayne J., Salvaris, Evelyn J., O'Connell, Philip J., Nottle, Mark B., d'Apice, Anthony J. F., Cowan, Peter J., Kearns-Jonker, Mary

“…Background Promising developments in porcine islet xenotransplantation could resolve the donor pancreas shortage for patients with type 1 diabetes. Using…”
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Glucose intolerance in a xenotransplantation model: studies in alpha-gal knockout mice by DAHL, KIRSTEN, BUSCHARD, KARSTEN, GRAM, DORTE X., D'APICE, ANTHONY J. F., HANSEN, AXEL K.

“…Xenotransplantation holds the promise of replacing failing human organs with organs of animal origin. Transplantation of pancreatic islets from pigs to humans…”
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Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury by Cai, Ming, Huttinger, Zachary M, He, Heng, Zhang, Weizhi, Li, Feng, Goodman, Lauren A, Wheeler, Debra G, Druhan, Lawrence J, Zweier, Jay L, Dwyer, Karen M, He, Guanglong, d'Apice, Anthony J.F, Robson, Simon C, Cowan, Peter J, Gumina, Richard J

“…Abstract Modulation of purinergic signaling is critical to myocardial homeostasis. Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which…”
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Subcutaneous pig islet xenografts: getting under your skin to cure diabetes? by Cowan, Peter J, d'Apice, Anthony J F

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Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models by Stewart, John M., Tarantal, Alice F., Hawthorne, Wayne J., Salvaris, Evelyn J., O'Connell, Philip J., Nottle, Mark B., d'Apice, Anthony J. F., Cowan, Peter J., Kearns-Jonker, Mary

“…Background Survival of vascularized xenografts is dependent on pre‐emptive inhibition of the xenoantibody response against galactosyltransferase knockout…”
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Enzymatic Properties of an Ecto-nucleoside Triphosphate Diphosphohydrolase from Legionella pneumophila: SUBSTRATE SPECIFICITY AND REQUIREMENT FOR VIRULENCE by Sansom, Fiona M, Riedmaier, Patrice, Newton, Hayley J, Dunstone, Michelle A, Müller, Christa E, Stephan, Holger, Byres, Emma, Beddoe, Travis, Rossjohn, Jamie, Cowan, Peter J, d'Apice, Anthony J.F, Robson, Simon C, Hartland, Elizabeth L

“…Legionella pneumophila is the predominant cause of Legionnaires disease, a severe and potentially fatal form of pneumonia. Recently, we identified an…”
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Intravascular thrombosis in discordant xenotransplantation by CRIKIS, Sandra, COWAN, Peter J, D'APICE, Anthony J. F

“…A series of immunological and physiological barriers must be overcome for the successful clinical application of xenotransplantation. The acute phases of…”
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Optimizing transduction of pig islet cell clusters for xenotransplantation by Londrigan, Sarah L., Brady, Jamie L., Sutherland, Robyn M., Cowan, Peter J., D'Apice, Anthony J. F., Hawthorne, Wayne J., O'Connell, Philip J., Lew, Andrew M.

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