Search Results - "D'alessio, Silvia"

Revisiting fibrosis in inflammatory bowel disease: the gut thickens by D’Alessio, Silvia, Ungaro, Federica, Noviello, Daniele, Lovisa, Sara, Peyrin-Biroulet, Laurent, Danese, Silvio

“…Intestinal fibrosis, which is usually the consequence of chronic inflammation, is a common complication of inflammatory bowel disease (IBD), including Crohn’s…”
Get full text

The Role of Pro-Resolving Lipid Mediators in Colorectal Cancer-Associated Inflammation: Implications for Therapeutic Strategies by Ungaro, Federica, D’Alessio, Silvia, Danese, Silvio

“…Inflammation is a recognized hallmark of cancer that contributes to the development and progression of colorectal cancer (CRC). Anti-inflammatory drugs…”
Get full text

PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue by Spadaccini, Marco, D'Alessio, Silvia, Peyrin-Biroulet, Laurent, Danese, Silvio

“…In the last few decades, a better knowledge of the inflammatory pathways involved in the pathogenesis of Inflammatory Bowel Disease (IBD) has promoted…”
Get full text

Actors and Factors in the Resolution of Intestinal Inflammation: Lipid Mediators As a New Approach to Therapy in Inflammatory Bowel Diseases by Ungaro, Federica, Rubbino, Federica, Danese, Silvio, D'Alessio, Silvia

“…In the last few decades, the pathogenesis of inflammatory bowel disease (IBD) in genetically predisposed subjects susceptible to specific environmental factors…”
Get full text

The gut virome in inflammatory bowel disease pathogenesis: From metagenomics to novel therapeutic approaches by Ungaro, Federica, Massimino, Luca, D’Alessio, Silvia, Danese, Silvio

“…Summary The association of intestinal dysbiosis with the pathogenesis of inflammatory bowel disease has been well established. Besides bacteria, microbiota…”
Get full text

Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease by Ungaro, Federica, Massimino, Luca, Furfaro, Federica, Rimoldi, Valeria, Peyrin-Biroulet, Laurent, D'Alessio, Silvia, Danese, Silvio

“…Intestinal dysbiosis is one of the causes underlying the pathogenesis of inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's…”
Get full text

The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework by Massimino, Luca, Lamparelli, Luigi Antonio, Houshyar, Yashar, D'Alessio, Silvia, Peyrin-Biroulet, Laurent, Vetrano, Stefania, Danese, Silvio, Ungaro, Federica

“…Inflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis is still unknown. Despite the high number of IBD-related omics studies, the…”
Get full text

Beyond Intestinal Barrier: The Blood Endothelium as a Second Wall of Defense Against Bacterial Invasion by Ungaro, Federica, Tacconi, Carlotta, D’Alessio, Silvia

Get full text

Tofacitinib Inhibits Leukocyte Trafficking Across the Intestinal Endothelial Barrier in a Specific Cohort of Ulcerative Colitis Patients by Massimino, Luca, Spanò, Salvatore, Lamparelli, Luigi Antonio, Fuggetta, Davide, Peyrin-Biroulet, Laurent, Sileri, Pierpaolo, Danese, Silvio, D’Alessio, Silvia, Ungaro, Federica

“…Lay Summary The JAK/STAT inhibitor tofacitinib, recently approved for the treatment of ulcerative colitis, is found to modulate the intestinal endothelial…”
Get full text

Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease by D’Alessio, Silvia, Tacconi, Carlotta, Fiocchi, Claudio, Danese, Silvio

“…PURPOSE OF REVIEWThe review summarizes the current knowledge of the roles played by the vascular and lymphatic endothelium throughout the gut in the…”
Get full text

TNF‐Stimulated Gene‐6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells by Romano, Barbara, Elangovan, Sudharshan, Erreni, Marco, Sala, Emanuela, Petti, Luciana, Kunderfranco, Paolo, Massimino, Luca, Restelli, Silvia, Sinha, Shruti, Lucchetti, Donatella, Anselmo, Achille, Colombo, Federico Simone, Stravalaci, Matteo, Arena, Vincenzo, D'Alessio, Silvia, Ungaro, Federica, Inforzato, Antonio, Izzo, Angelo A., Sgambato, Alessandro, Day, Anthony J., Vetrano, Stefania

“…Mesenchymal stem cells (MSCs) are well established to have promising therapeutic properties. TNF‐stimulated gene‐6 (TSG‐6), a potent tissue‐protective and…”
Get full text

Targeting lymphatics in inflammatory bowel disease by D'Alessio, Silvia, Tacconi, Carlotta, Danese, Silvio

Get full text

The protein C pathway in intestinal barrier function: challenging the hemostasis paradigm by D'Alessio, Silvia, Genua, Marco, Vetrano, Stefania

“…The protein C (PC) pathway is a well‐characterized anticoagulant system. Produced mainly by the liver as a zymogen, PC is activated on the vascular endothelial…”
Get full text

Haematopoietic prolyl hydroxylase‐1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis by Van Welden, Sophie, De Vos, Martine, Wielockx, Ben, Tavernier, Simon J, Dullaers, Melissa, Neyt, Sara, Descamps, Benedicte, Devisscher, Lindsey, Devriese, Sarah, Van den Bossche, Lien, Holvoet, Tom, Baeyens, Ann, Correale, Carmen, D'Alessio, Silvia, Vanhove, Christian, De Vos, Filip, Verhasselt, Bruno, Breier, Georg, Lambrecht, Bart N, Janssens, Sophie, Carmeliet, Peter, Danese, Silvio, Elewaut, Dirk, Laukens, Debby, Hindryckx, Pieter

“…Prolyl hydroxylase domain‐containing proteins (PHDs) regulate the adaptation of cells to hypoxia. Pan‐hydroxylase inhibition is protective in experimental…”
Get full text

Author Correction: The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework by Massimino, Luca, Lamparelli, Luigi Antonio, Houshyar, Yashar, D’Alessio, Silvia, Peyrin-Biroulet, Laurent, Vetrano, Stefania, Danese, Silvio, Ungaro, Federica

Get full text

mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease by Ungaro, Federica, Garlatti, Valentina, Massimino, Luca, Spinelli, Antonino, Carvello, Michele, Sacchi, Matteo, Spanò, Salvatore, Colasante, Gaia, Valassina, Nicholas, Vetrano, Stefania, Malesci, Alberto, Peyrin-Biroulet, Laurent, Danese, Silvio, D'Alessio, Silvia

“…Crohn's disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated…”
Get full text

Chromogranin A binds to αvβ6-integrin and promotes wound healing in mice by Curnis, Flavio, Gasparri, Anna Maria, Longhi, Renato, Colombo, Barbara, D’Alessio, Silvia, Pastorino, Fabio, Ponzoni, Mirco, Corti, Angelo

“…Chromogranin A (CgA), a secretory protein expressed by many neuroendocrine cells, neurons, cardiomyocytes, and keratinocytes, is the precursor of various…”
Get full text

Tissue Inhibitor of Metalloproteinases-2 Binding to Membrane-type 1 Matrix Metalloproteinase Induces MAPK Activation and Cell Growth by a Non-proteolytic Mechanism by D'Alessio, Silvia, Ferrari, Giovanni, Cinnante, Karma, Scheerer, William, Galloway, Aubrey C., Roses, Daniel F., Rozanov, Dmitri V., Remacle, Albert G., Oh, Eok-Soo, Shiryaev, Sergey A., Strongin, Alex Y., Pintucci, Giuseppe, Mignatti, Paolo

“…Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with a short cytoplasmic domain and an extracellular catalytic domain, controls…”
Get full text

Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion by Tacconi, Carlotta, Correale, Carmen, Gandelli, Alessandro, Spinelli, Antonino, Dejana, Elisabetta, D’Alessio, Silvia, Danese, Silvio

“…Background & Aims Colorectal cancer (CRC) is highly metastatic. Metastases spread directly into local tissue or invade distant organs via blood and lymphatic…”
Get full text

VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease by D'Alessio, Silvia, Correale, Carmen, Tacconi, Carlotta, Gandelli, Alessandro, Pietrogrande, Giovanni, Vetrano, Stefania, Genua, Marco, Arena, Vincenzo, Spinelli, Antonino, Peyrin-Biroulet, Laurent, Fiocchi, Claudio, Danese, Silvio

“…Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) of unknown etiology that are associated with an aberrant…”
Get full text