A structure activity relationship study on position-2 of the Gαs C-terminal peptide able to inhibit Gs activation by A2A adenosine receptor

A structure activity relationship study on position-2 of the Gαs C-terminal peptide able to inhibit Gs activation by A2A adenosine receptor

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Bibliographic Details
Published in:European journal of medicinal chemistry Vol. 38; no. 1; pp. 13 - 18
Main Authors: GRIECO, Paolo, ALBRIZIO, Stefania, D'URI, Anna Maria, GIUSTI, Laura, MAZZONI, Maria R, NOVELLINO, Ettore, ROVERO, Paolo
Format: Journal Article
Language:English
Published: Oxford Elsevier 2003
Subjects:
Biological and medical sciences
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
Peptides
Enzyme
Phosphorus-oxygen lyases
Enzyme inhibitor
Molecular dynamics
Lyases
In vitro
Modeling
A2A receptors
A2A adenosine receptor
C terminal-Sequence
Adenylate cyclase
Signal transduction
Structure activity relation
Polypeptide
Molecular model
Force field method
Peptide synthesis
Synthetic peptides
Inhibition
Solid phase
Chemical synthesis
G protein
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Description
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(02)00010-7