Search Results - "D'Souza, Ursula M."

The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity by Parsons, Michael J., D'Souza, Ursula M., Arranz, Maria-Jesus, Kerwin, Robert W., Makoff, Andrew J.

“…The –1438A/G single nucleotide polymorphism (SNP) lies just upstream of two alternative promoters for the 5-hydroxytryptamine type 2A (5-HT2A) receptor gene…”
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Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients by Powell, Timothy R, McGuffin, Peter, D'Souza, Ursula M, Cohen-Woods, Sarah, Hosang, Georgina M, Martin, Charlotte, Matthews, Keith, Day, Richard K, Farmer, Anne E, Tansey, Katherine E, Schalkwyk, Leonard C

“…Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These…”
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Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders by D'Souza, Ursula M, Craig, Ian W

“…Many genes in the monoamine neurotransmitter pathways possess functional variants which have been associated with human behavioural disorders and traits,…”
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ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway by Powell, Timothy R, Tansey, Katherine E, Breen, Gerome, Farmer, Anne E, Craig, Ian W, Uher, Rudolf, McGuffin, Peter, D’Souza, Ursula M, Schalkwyk, Leonard C

“…The inflammatory cytokine pathway may be a potential therapeutic target for major depressive disorder (MDD). Previous reports suggest that antidepressants have…”
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Functional polymorphisms in dopamine and serotonin pathway genes by D'Souza, Ursula M., Craig, Ian W.

“…There is mounting evidence on the functional significance of single nucleotide and simple repeat sequence polymorphisms in both the coding and regulatory…”
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Genes within the serotonergic system are differentially expressed in human brain by Sugden, Karen, Tichopad, Ales, Khan, Nadeem, Craig, Ian W, D'Souza, Ursula M

“…Serotonin is an important neurotransmitter with wide-ranging functions throughout the central nervous system. There is strong evidence to suggest that…”
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Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response by Powell, Timothy R, Schalkwyk, Leonard C, Heffernan, Andrew L, Breen, Gerome, Lawrence, Timothy, Price, Tom, Farmer, Anne E, Aitchison, Katherine J, Craig, Ian W, Danese, Andrea, Lewis, Cathryn, McGuffin, Peter, Uher, Rudolf, Tansey, Katherine E, D'Souza, Ursula M

“…Abstract Converging evidence suggests that the activation of the inflammatory cytokine pathway is important in the pathophysiology of unipolar depression…”
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Dopamine Receptor Regulating Factor, DRRF: A Zinc Finger Transcription Factor by Hwang, Cheol Kyu, D'Souza, Ursula M., Eisch, Amelia J., Yajima, Shunsuke, Lammers, Claas-Hinrich, Yang, Young, Lee, Sang-Hyeon, Kim, Yong-Man, Nestler, Eric J., Mouradian, M. Maral

“…Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger…”
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Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue by Brookes, Keeley J., Neale, Benjamin M., Sugden, Karen, Khan, Nadeem, Asherson, Philip, D'Souza, Ursula M.

“…Attention deficit hyperactivity disorder (ADHD) is currently one of the most prevalent childhood behavioral disorders. The disorder is found to be highly…”
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Functional effects of a tandem duplication polymorphism in the 5′flanking region of the DRD4 gene by D’Souza, Ursula M., Russ, Carsten, Tahir, Eda, Mill, Jonathan, McGuffin, Peter, Asherson, Philip J., Craig, Ian W.

“…Several polymorphisms have been identified in the 5′flanking region of the human dopamine D 4 receptor gene (DRD4), including a tandem duplication…”
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Mood-stabilizers differentially affect housekeeping gene expression in human cells by Powell, Timothy R., Powell-Smith, Georgia, Haddley, Kate, Mcguffin, Peter, Quinn, John, Schalkwyk, Leonard C., Farmer, Anne E., D'Souza, Ursula M.

“…Recent studies have revealed that antidepressants affect the expression of constitutively expressed “housekeeping genes” commonly used as normalizing reference…”
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Allele-specific expression of the serotonin transporter and its transcription factors following lamotrigine treatment in vitro by D'Souza, Ursula M., Powell-Smith, Georgia, Haddley, Kate, Powell, Timothy R., Bubb, Vivien J., Price, Tom, McGuffin, Peter, Quinn, John P., Farmer, Anne E.

“…Lamotrigine, a mood stabilizer used clinically in the treatment of bipolar disorder, is thought to exert actions on the serotonin system. However lamotrigine's…”
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Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1) by Mill, Jonathan, Asherson, Philip, Craig, Ian, D'Souza, Ursula M

“…The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been…”
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Three-amino acid Extension Loop Homeodomain Proteins Meis2 and TGIF Differentially Regulate Transcription by Yang, Young, Hwang, Cheol Kyu, D'Souza, Ursula M., Lee, Sang-Hyeon, Junn, Eunsung, Mouradian, M.Maral

“…Three-amino acid extension loop (TALE) homeobox proteins are highly conserved transcription regulators. We report that two members of this family, Meis2 and…”
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From transcriptional regulation to aggressive behavior by D'Souza, Ursula M, Kel, Alexander, Sluyter, Frans

“…Gene expression in higher organisms, is, to a large degree, controlled at the level of transcription, where DNA-binding proteins (transcription factors) play…”
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Characterization of the 5′ flanking region of the rat D3 dopamine receptor gene by D'Souza, Ursula M., Wang, Wei, Gao, Da‐Qing, Kanda, Seiji, Lee, Gwang, Junn, Eunsung, Hwang, Cheol Kyu, Jose, Pedro A., Mouradian, M. Maral

“…The D3 dopamine receptor has a restricted regional distribution in brain and is regulated by dopaminergic agents. Additionally, the D3 gene is implicated in…”
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Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene by D'SOUZA, Ursula M, RUSS, Carsten, TAHIR, Eda, MILL, Jonathan, MCGUFFIN, Peter, ASHERSON, Philip J, CRAIG, Ian W

“…Several polymorphisms have been identified in the 5'flanking region of the human dopamine D(4) receptor gene (DRD4), including a tandem duplication…”
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Regulation of striatal dopamine receptors by corticosterone: an in vivo and in vitro study by Lammers, Claas-Hinrich, D'Souza, Ursula M, Qin, Zheng-Hong, Lee, Sang-Hyeon, Yajima, Shunsuke, Mouradian, M.Maral

“…The effects of chronic corticosterone administration and adrenalectomy on the expression of brain dopamine receptors were studied in rats. In situ…”
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Developmental expression of the zinc finger transcription factor DRRF (dopamine receptor regulating factor) by D'Souza, Ursula M., Lammers, Claas-Hinrich, Hwang, Cheol Kyu, Yajima, Shunsuke, Mouradian, M.Maral

“…Dopamine receptor regulating factor (DRRF) is a novel transcription factor with unique anatomical distribution and functional properties, suggesting its…”
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Genetic Organization of the Serotonergic System by D'Souza, Ursula M., Craig, Ian W.

“…The serotonergic system consists of a number of genes and includes seven subfamilies of serotonin receptors (5-HT1-7), with each subfamily revealing several…”
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