Search Results - "D'Souza, Ursula"

Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients by Powell, Timothy R, McGuffin, Peter, D'Souza, Ursula M, Cohen-Woods, Sarah, Hosang, Georgina M, Martin, Charlotte, Matthews, Keith, Day, Richard K, Farmer, Anne E, Tansey, Katherine E, Schalkwyk, Leonard C

“…Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These…”
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Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response by Powell, Timothy R, Schalkwyk, Leonard C, Heffernan, Andrew L, Breen, Gerome, Lawrence, Timothy, Price, Tom, Farmer, Anne E, Aitchison, Katherine J, Craig, Ian W, Danese, Andrea, Lewis, Cathryn, McGuffin, Peter, Uher, Rudolf, Tansey, Katherine E, D'Souza, Ursula M

“…Abstract Converging evidence suggests that the activation of the inflammatory cytokine pathway is important in the pathophysiology of unipolar depression…”
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The –1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity by Parsons, Michael J., D'Souza, Ursula M., Arranz, Maria-Jesus, Kerwin, Robert W., Makoff, Andrew J.

“…The –1438A/G single nucleotide polymorphism (SNP) lies just upstream of two alternative promoters for the 5-hydroxytryptamine type 2A (5-HT2A) receptor gene…”
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Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders by D'Souza, Ursula M, Craig, Ian W

“…Many genes in the monoamine neurotransmitter pathways possess functional variants which have been associated with human behavioural disorders and traits,…”
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Genes within the serotonergic system are differentially expressed in human brain by Sugden, Karen, Tichopad, Ales, Khan, Nadeem, Craig, Ian W, D'Souza, Ursula M

“…Serotonin is an important neurotransmitter with wide-ranging functions throughout the central nervous system. There is strong evidence to suggest that…”
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Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR by Mill, Jonathan, Asherson, Philip, Browes, Clare, D'Souza, Ursula, Craig, Ian

“…Genetic association studies provide considerable evidence that the 10‐repeat allele of a variable number tandem repeat (VNTR) in the 3′‐untranslated region…”
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Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue by Brookes, Keeley J., Neale, Benjamin M., Sugden, Karen, Khan, Nadeem, Asherson, Philip, D'Souza, Ursula M.

“…Attention deficit hyperactivity disorder (ADHD) is currently one of the most prevalent childhood behavioral disorders. The disorder is found to be highly…”
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ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway by Powell, Timothy R, Tansey, Katherine E, Breen, Gerome, Farmer, Anne E, Craig, Ian W, Uher, Rudolf, McGuffin, Peter, D’Souza, Ursula M, Schalkwyk, Leonard C

“…The inflammatory cytokine pathway may be a potential therapeutic target for major depressive disorder (MDD). Previous reports suggest that antidepressants have…”
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Functional polymorphisms in dopamine and serotonin pathway genes by D'Souza, Ursula M., Craig, Ian W.

“…There is mounting evidence on the functional significance of single nucleotide and simple repeat sequence polymorphisms in both the coding and regulatory…”
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Functional effects of a tandem duplication polymorphism in the 5′flanking region of the DRD4 gene by D’Souza, Ursula M., Russ, Carsten, Tahir, Eda, Mill, Jonathan, McGuffin, Peter, Asherson, Philip J., Craig, Ian W.

“…Several polymorphisms have been identified in the 5′flanking region of the human dopamine D 4 receptor gene (DRD4), including a tandem duplication…”
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Mood-stabilizers differentially affect housekeeping gene expression in human cells by Powell, Timothy R., Powell-Smith, Georgia, Haddley, Kate, Mcguffin, Peter, Quinn, John, Schalkwyk, Leonard C., Farmer, Anne E., D'Souza, Ursula M.

“…Recent studies have revealed that antidepressants affect the expression of constitutively expressed “housekeeping genes” commonly used as normalizing reference…”
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Allele-specific expression of the serotonin transporter and its transcription factors following lamotrigine treatment in vitro by D'Souza, Ursula M., Powell-Smith, Georgia, Haddley, Kate, Powell, Timothy R., Bubb, Vivien J., Price, Tom, McGuffin, Peter, Quinn, John P., Farmer, Anne E.

“…Lamotrigine, a mood stabilizer used clinically in the treatment of bipolar disorder, is thought to exert actions on the serotonin system. However lamotrigine's…”
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Dopamine Receptor Regulating Factor, DRRF: A Zinc Finger Transcription Factor by Hwang, Cheol Kyu, D'Souza, Ursula M., Eisch, Amelia J., Yajima, Shunsuke, Lammers, Claas-Hinrich, Yang, Young, Lee, Sang-Hyeon, Kim, Yong-Man, Nestler, Eric J., Mouradian, M. Maral

“…Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger…”
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Regulation of striatal dopamine receptors by estrogen by Lammers, Claas-Hinrich, D'Souza, Ursula, Qin, Zheng-Hong, Lee, Sang-Hyeon, Yajima, Shunsuke, Mouradian, M. Maral

“…The ability of estrogen to modulate the expression of ventral and dorsal striatal dopamine receptors D1, D2, and D3 was examined in vivo using…”
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Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1) by Mill, Jonathan, Asherson, Philip, Craig, Ian, D'Souza, Ursula M

“…The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been…”
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The invasion of Pteridium aquilinum and the impoverishment of the seed bank in fire prone areas of Brazilian Atlantic Forest by de Silva, Úrsula Souza Rodrigues da, Matos, Dalva M. da Silva

“…Several studies have documented that fires are widespread in the tropics. Because fire in the Atlantic Rain Forest is rare, fire events and their consequences…”
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From transcriptional regulation to aggressive behavior by D'Souza, Ursula M, Kel, Alexander, Sluyter, Frans

“…Gene expression in higher organisms, is, to a large degree, controlled at the level of transcription, where DNA-binding proteins (transcription factors) play…”
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A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs by Docherty, Sophia J, Davis, Oliver Sp, Haworth, Claire Ma, Plomin, Robert, D'Souza, Ursula, Mill, Jonathan

“…Dopamine receptor D4(DRD4) polymorphisms have been associated with a number of psychiatric disorders, but little is known about the mechanism of these…”
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Three-amino acid Extension Loop Homeodomain Proteins Meis2 and TGIF Differentially Regulate Transcription by Yang, Young, Hwang, Cheol Kyu, D'Souza, Ursula M., Lee, Sang-Hyeon, Junn, Eunsung, Mouradian, M.Maral

“…Three-amino acid extension loop (TALE) homeobox proteins are highly conserved transcription regulators. We report that two members of this family, Meis2 and…”
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Characterization of the 5′ flanking region of the rat D3 dopamine receptor gene by D'Souza, Ursula M., Wang, Wei, Gao, Da‐Qing, Kanda, Seiji, Lee, Gwang, Junn, Eunsung, Hwang, Cheol Kyu, Jose, Pedro A., Mouradian, M. Maral

“…The D3 dopamine receptor has a restricted regional distribution in brain and is regulated by dopaminergic agents. Additionally, the D3 gene is implicated in…”
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