Search Results - "D'Souza, Saritha"

Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells by Suknuntha, Kran, Tao, Lihong, Brok-Volchanskaya, Vera, D’Souza, Saritha S., Kumar, Akhilesh, Slukvin, Igor

“…Identification of transcription factors that directly convert pluripotent stem cells (PSCs) into endothelial and blood cells and advances in the chemical…”
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Understanding the Journey of Human Hematopoietic Stem Cell Development by Kumar, Akhilesh, Thakur, Abir S., D’Souza, Saritha S.

“…Hematopoietic stem cells (HSCs) surface during embryogenesis leading to the genesis of the hematopoietic system, which is vital for immune function,…”
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NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells with High Proliferation Potential from Human Pluripotent Stem Cells by Kumar, Akhilesh, Lee, Jeong Hee, Suknuntha, Kran, D'Souza, Saritha S, Thakur, Abir S, Slukvin, Igor I

“…Human pluripotent stem cells (hPSCs) offer the potential to serve as a versatile and scalable source of T cells for immunotherapies, which could be coupled…”
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Functional Heterogeneity of Endothelial Cells Derived from Human Pluripotent Stem Cells by D'Souza, Saritha S, Kumar, Akhilesh, Slukvin, Igor I

“…Specification of endothelial cells (ECs) into arterial, venous, and lymphatic cells is a crucial process of vascular development, and expanding our knowledge…”
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Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes by Ozog, Stosh, Timberlake, Nina D., Hermann, Kip, Garijo, Olivia, Haworth, Kevin G., Shi, Guoli, Glinkerman, Christopher M., Schefter, Lauren E., D'Souza, Saritha, Simpson, Elizabeth, Sghia-Hughes, Gabriella, Carillo, Raymond R., Boger, Dale L., Kiem, Hans-Peter, Slukvin, Igor, Ryu, Byoung Y., Sorrentino, Brian P., Adair, Jennifer E., Snyder, Scott A., Compton, Alex A., Torbett, Bruce E.

“…Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases…”
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GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells by D'Souza, Saritha S., Maufort, John, Kumar, Akhilesh, Zhang, Jiuchun, Smuga-Otto, Kimberley, Thomson, James A., Slukvin, Igor I.

“…Advances in the scalable production of blood cells from induced pluripotent stem cells (iPSCs) open prospects for the clinical translation of de novo generated…”
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Transplantation of T-cell receptor α/β-depleted allogeneic bone marrow in nonhuman primates by D'Souza, Saritha S., Bennett, Sarah, Kumar, Akhilesh, Kelnhofer, Laurel E., Weinfurter, Jason, Suknuntha, Kran, Coonen, Jennifer, Mejia, Andres, Simmons, Heather, Golos, Thaddeus, Hematti, Peiman, Capitini, Christian M., Reynolds, Matthew R., Slukvin, Igor I.

“…•TCRα/β depletion and sirolimus do not prevent GvHD after MHC-matched alloHSCT in Mauritian cynomolgus macaques.•Cyclophosphamide allows mixed chimerism…”
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Angiopoietin-2 inhibition using siRNA or the peptide antagonist L1–10 results in antitumor activity in human neuroblastoma by D’Souza, Saritha Sandra, Scherzinger-Laude, Karine, Simon, Marc, Salimath, Bharathi P., Rössler, Jochen

“…Purpose The angiopoietin/Tie-2 system has been identified as a key role player in tumor angiogenesis. We investigated whether angiopoietin-2 could be a…”
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Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts by Kumar, Akhilesh, D’Souza, Saritha Sandra, Moskvin, Oleg V., Toh, Huishi, Wang, Bowen, Zhang, Jue, Swanson, Scott, Guo, Lian-Wang, Thomson, James A., Slukvin, Igor I.

“…Elucidating the pathways that lead to vasculogenic cells, and being able to identify their progenitors and lineage-restricted cells, is critical to the…”
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Antiangiogenic and Proapoptotic Activities of Allyl Isothiocyanate Inhibit Ascites Tumor Growth in Vivo by Kumar, Akhilesh, D'Souza, Saritha S., Tickoo, Sanjay, Salimath, Bharathi P., Singh, H.B.

“…The authors investigate the antiangiogenic and proapoptotic effects of mustard essential oil containing allyl isothiocyanate (AITC) and explore its mechanism…”
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Mesenchymoangioblast-derived mesenchymal stromal cells inhibit cell damage, tissue damage and improve peripheral blood flow following hindlimb ischemic injury in mice by Koch, Jill M, D'Souza, Saritha S, Schwahn, Denise J, Dixon, Ian, Hacker, Timothy A

“…Abstract Background aims Existing treatments have limited success in modifying the course of peripheral artery disease, which may eventually lead to…”
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Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques by Weinfurter, Jason T., D’Souza, Saritha S., Matschke, Lea M., Bennett, Sarah, Kelnhofer-Millevolte, Laurel E., Suknuntha, Kran, Kumar, Akhilesh, Coonen, Jennifer, Capitini, Christian M., Hematti, Peiman, Golos, Thaddeus G., Slukvin, Igor I., Reynolds, Matthew R.

“…Allogeneic hematopoietic stem cell transplants (allo-HSCTs) dramatically reduce HIV reservoirs in antiretroviral therapy (ART) suppressed individuals. However,…”
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Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus by D’Souza, Saritha S., Kumar, Akhilesh, Weinfurter, Jason, Park, Mi Ae, Maufort, John, Tao, Lihong, Kang, HyunJun, Dettle, Samuel T., Golos, Thaddeus, Thomson, James A., Reynolds, Matthew R., Slukvin, Igor

“…Adoptive therapies with genetically modified somatic T cells rendered HIV resistance have shown promise for AIDS therapy. A renewable source of HIV-resistant…”
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Assessment of Safety and Immunogenicity of MHC homozygous iPSC-derived CD34+ Hematopoietic Progenitors in a NHP Model by D'Souza, Saritha S., Kumar, Akhilesh, Maufort, John, Weinfurter, Jason T., Raymond, Matthew, Strelchenko, Nick S., Perrin, Elizabeth, Coonen, Jennifer, Mejia, Andres, Simmons, Heather A., Torbett, Bruce E, Reynolds, Matthew, Thomson, James A, Slukvin, Igor I

“…Administration of ex vivo expanded somatic myeloid progenitors has been explored as a way to facilitate a more rapid myeloid recovery and improve overall…”
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Generation of T cells from Human and Nonhuman Primate Pluripotent Stem Cells by Kumar, Akhilesh, D'Souza, Saritha S, Uenishi, Gene, Park, Mi Ae, Lee, Jeong Hee, Slukvin, Igor I

“…Pluripotent stem cells (PSCs) have the potential to provide homogeneous cell populations of T cells that can be grown at a clinical scale and genetically…”
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Deletion of the Artery Specific Enhancer Promotes B Cell and Impairs T Cell Development from the Hemogenic Endothelium by D'souza, Saritha S., Kumar, Akhilesh, Choi, Yoon Jung, Dettle, Samuel, Emmen, Isla, Smith, Portia, Sedzro, Divine M., Jung, Ho Sun, Liu, Peng, Slukvin, Igor

“…HSCs and HSC-independent lymphoid progenitors in the embryo arise from hemogenic endothelium (HE) at multiple anatomical locations. Although activation of…”
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Artery Specific Enhancer Is Essential for Specification of Arterial Hemogenic Endothelium with T Lymphoid Potential by D'souza, Saritha S, Kumar, Akhilesh, Choi, Yoon Jung, Dettle, Samuel T, Smith, Portia, Jung, Ho Sun, Liu, Peng, Ong, Irene, Slukvin, Igor I

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Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by a new series of substituted-1,3,4-oxadiazole derivatives by Kumar, Akhilesh, D’Souza, Saritha S., Gaonkar, S. L., Rai, K. M. L., Salimath, Bharathi P.

“…Summary The multiple pharmacological actions of unique synthetic compounds are a prerequisite for classifying a drug as highly efficacious, because the…”
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Infusion of iPSC-Derived CD34 + Hematopoietic Progenitors Following Myeloablative HSC Transplantation and Assessment of Their Immunogenicity in MHC-Defined Nonhuman Primate Model by D'souza, Saritha S, Kumar, Akhilesh, Maufort, John P, Strelchenko, Nick, Raymond, Mathew, Weinfurter, Jason, Coonen, Jennifer, Reynolds, Matt, Thomson, James A., Slukvin, Igor I

“…Bone marrow suppression and associated neutropenia that renders the patient more susceptible to infection is a major complication and limiting factor for…”
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Antiangiogenic and antiproliferative effects of substituted-1,3,4-oxadiazole derivatives is mediated by down regulation of VEGF and inhibition of translocation of HIF-1α in Ehrlich ascites tumor cells by Kumar, Akhilesh, D'Souza, Saritha S, Mysore Nagaraj, Sachin Raj, Gaonkar, S. L, Salimath, Bharathi P, Rai, K. M. Lokanatha

“…Purpose 1,3,4-Oxadiazoles are an important class of heterocyclic compounds, which play a pivotal role in various pharmaceutical applications. Here, we…”
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