Search Results - "D'Souza, Gerard G. M."

Organelle-Targeted Nanocarriers: Specific Delivery of Liposomal Ceramide to Mitochondria Enhances Its Cytotoxicity in Vitro and in Vivo by Boddapati, Sarathi V, D’Souza, Gerard G. M, Erdogan, Suna, Torchilin, Vladimir P, Weissig, Volkmar

“…To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the…”
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Nanomechanical Analysis of Extracellular Matrix and Cells in Multicellular Spheroids by Vyas, Varun, Solomon, Melani, D’Souza, Gerard G. M., Huey, Bryan D.

“…Introduction Over the last decade, atomic force microscopy (AFM) has played an important role in understanding nanomechanical properties of various cancer cell…”
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Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein by Wang, Tao, D'Souza, Gerard G M, Bedi, Deepa, Fagbohun, Olusegun A, Potturi, L Prasanna, Papahadjopoulos-Sternberg, Brigitte, Petrenko, Valery A, Torchilin, Vladimir P

“…To explore cancer cell-specific phage fusion pVIII coat protein, identified using phage display, for targeted delivery of drug-loaded liposomes to MCF-7 breast…”
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Palmitoyl Ascorbate-Loaded Polymeric Micelles: Cancer Cell Targeting and Cytotoxicity by Sawant, Rupa R, Vaze, Onkar, D'Souza, Gerard G. M, Rockwell, Karen, Torchilin, Vladimir P

“…Purpose To evaluate the potential of palmitoyl ascorbate (PA)-loaded micelles for ascorbate-mediated cancer cell targeting and cytotoxicity. Methods PA was…”
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Palmitoyl Ascorbate Liposomes and Free Ascorbic Acid: Comparison of Anticancer Therapeutic Effects Upon Parenteral Administration by Sawant, Rupa R., Vaze, Onkar S., Wang, Tao, D’Souza, Gerard G. M., Rockwell, Karen, Gada, Keyur, Khaw, Ban-An, Torchilin, Vladimir P.

“…ABSTRACT Purpose To evaluate and compare anticancer therapeutic effect of palmitoyl ascorbate liposomes (PAL) and free ascorbic acid (AA). Methods Liposomes…”
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Surface Modification of Pharmaceutical Nanocarriers with Ascorbate Residues Improves their Tumor-Cell Association and Killing and the Cytotoxic Action of Encapsulated Paclitaxel In Vitro by D’Souza, Gerard G. M., Wang, Tao, Rockwell, Karen, Torchilin, Vladimir P.

“…Purpose To evaluate the potential of ascorbate as a novel ligand in the preparation of pharmaceutical nanocarriers with enhanced tumor-cell specific binding…”
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The Utility of an Isolated Mitochondrial Fraction in the Preparation of Liposomes for the Specific Delivery of Bioactives to Mitochondria in Live Mammalian Cells by Wagle, Mayura A., Martinville, Laura E., D’Souza, Gerard G. M.

“…ABSTRACT Purpose To develop and evaluate liposomal formulations prepared with an isolated mitochondrial fraction as a mitochondria-specific delivery vehicle…”
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Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel by D'Souza, Gerard GM, Cheng, Shing-Ming, Boddapati, Sarathi V, Horobin, Richard W, Weissig, Volkmar

“…Many drug molecules exert their biological action on intracellular molecular targets present on or inside various cellular organelles. Consequently, it has…”
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Gene therapy of the other genome : The challenges of treating mitochondrial DNA defects by D'SOUZA, Gerard G. M, BODDAPATI, Sarathi V, WEISSIG, Volkmar

“…Human mitochondrial DNA is a 16.5 kb circular DNA molecule located inside the mitochondrial matrix. Although accounting for only about 1% of total cellular…”
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Subcellular targeting: a new frontier for drug-loaded pharmaceutical nanocarriers and the concept of the magic bullet by D'Souza, Gerard G M, Weissig, Volkmar

“…The ability of a pharmacologically active molecule selectively to find its target is closely linked with its potential as a successful therapeutic drug. It has…”
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On the Mechanism of Targeting of Phage Fusion Protein-Modified Nanocarriers: Only the Binding Peptide Sequence Matters by Wang, Tao, Kulkarni, Nikita, D’Souza, Gerard G. M, Petrenko, Valery A, Torchilin, Vladimir P

“…The integration of pharmaceutical nanocarriers with phage display techniques is emerging as a new paradigm for targeted cancer nanomedicines. We explored the…”
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In Vitro Testing of Anticancer Nanotherapeutics Using Tumor Spheroids by Ganpule, Avanti, Gui, Zishu, Almuteri, Mohammed A, D'Souza, Gerard G M

“…Tumor cells grown as spheroids more closely resemble in vivo solid tumors and present physical and physiological barriers to drug action that conventional…”
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In vitro optimization of liposomal nanocarriers prepared from breast tumor cell specific phage fusion protein by Wang, Tao, Kulkarni, Nikita, Bedi, Deepa, D'Souza, Gerard GM, Papahadjopoulos-Sternberg, Brigitte, Petrenko, Valery A., Torchilin, Vladimir P.

“…Fusion proteins created by phage display peptides with tumor cell specificity and the pVIII major coat protein of filamentous phages have been explored…”
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Cell Transfection in vitro and in vivo with Nontoxic TAT Peptide-Liposome-DNA Complexes by Torchilin, Vladimir P., Levchenko, Tatyana S., Rammohan, Ram, Volodina, Natalia, Papahadjopoulos-Sternberg, Brigitte, Gerard G. M. D'Souza

“…Liposomes modified with TAT peptide (TATp-liposomes) showed fast and efficient translocation into the cell cytoplasm with subsequent migration into the…”
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Development of an in vitro tumor spheroid culture model amenable to high-throughput testing of potential anticancer nanotherapeutics by Solomon, Melani A., Lemera, Jenkins, D'Souza, Gerard G. M.

“…Context: Three-dimensional tumor spheroid cultures are a better representative of in vivo solid tumors than monolayer cultures and should be used for testing…”
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Hydrophobized triphenyl phosphonium derivatives for the preparation of mitochondriotropic liposomes: choice of hydrophobic anchor influences cytotoxicity but not mitochondriotropic effect by Benien, Parul, Solomon, Melani A., Nguyen, Paul, Sheehan, Erin M., Mehanna, Ahmed S., D'Souza, Gerard G. M.

“…Context: Nanocarrier-based strategies to achieve delivery of bioactives specifically to the mitochondria are being increasingly explored due to the importance…”
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Recent progress in the therapeutic applications of nanotechnology by Solomon, Melani, D'Souza, Gerard G M

“…The field of pharmaceutical and medical nanotechnology has grown rapidly in recent decades and offers much promise for therapeutic advances. This review is…”
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Liposomes and Liposome-like Vesicles for Drug and DNA Delivery to Mitochondria by Weissig, Volkmar, Boddapati, Sarathi V., Cheng, Shing-Ming, D'souza, Gerard G. M.

“…Mitochondrial research is presently one of the fastest growing disciplines in biomedicine. Since the early 1990s, it has become increasingly evident that…”
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Approaches for targeting mitochondria in cancer therapy by D'Souza, Gerard G.M., Wagle, Mayura A, Saxena, Vaibhav, Shah, Anee

“…The recognition of the role that mitochondria play in human health and disease is evidenced by the emergence in recent decades of a whole new field of…”
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In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel by Solomon, Melani A, Shah, Anee A, D'Souza, Gerard G M

“…Paclitaxel loaded in liposomes modified with stearyl triphenyl phosphonium (STPP) showed improved mitochondrial colocalization and cytotoxicity in a paclitaxel…”
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