Search Results - "D'Souza, Deborah"

Efficacy of Galcanezumab for Migraine Prevention in Patients With a Medical History of Anxiety and/or Depression: A Post Hoc Analysis of the Phase 3, Randomized, Double‐Blind, Placebo‐Controlled REGAIN, and Pooled EVOLVE‐1 and EVOLVE‐2 Studies by Smitherman, Todd A., Tietjen, Gretchen E., Schuh, Kory, Skljarevski, Vladimir, Lipsius, Sarah, D’Souza, Deborah N., Pearlman, Eric M.

“…Objective This post hoc analysis evaluated the efficacy of galcanezumab for the prevention of migraine in patients with and without comorbid anxiety and/or…”
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A closer look at the baseline-observation-carried-forward (BOCF) by Liu-Seifert, Hong, Zhang, Shuyu, D'Souza, Deborah, Skljarevski, Vladimir

“…The baseline-observation-carried-forward (BOCF) approach is one method to handle missing data from early treatment discontinuation. We examined modifications…”
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A Double-Blind, Randomized Multicenter Trial Comparing Duloxetine with Placebo in the Management of Diabetic Peripheral Neuropathic Pain by Raskin, Joel, Pritchett, Yili L., Wang, Fujun, D'Souza, Deborah N., Waninger, Amy L., Iyengar, Smriti, Wernicke, Joachim F.

“…ABSTRACT Objective.  Assess efficacy and safety of duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, on the reduction of pain severity,…”
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A randomized, double-blind study comparing LY2216684 and placebo in the treatment of major depressive disorder by Pangallo, Beth, Dellva, Mary Anne, D’Souza, Deborah N, Essink, Beal, Russell, James, Goldberger, Celine

“…Abstract The efficacy, tolerability, and safety of LY2216684, a highly selective norepinephrine reuptake inhibitor, were studied in adult patients with major…”
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Efficacy of Continuous Dosing of Tadalafil Once Daily vs Tadalafil On Demand in Clinical Subgroups of Men With Erectile Dysfunction: A Descriptive Comparison Using the Integrated Tadalafil Databases by Brock, Gerald, Ni, Xiao, Oelke, Matthias, Mulhall, John, Rosenberg, Matt, Seftel, Allen, D'Souza, Deborah, Barry, Jane

“…Various factors play a role in the development of erectile dysfunction (ED). To provide a descriptive comparison of erectile function response for tadalafil…”
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A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder by Arnold, Lesley M., Rosen, Amy, Pritchett, Yili Lu, D'Souza, Deborah N., Goldstein, David J., Iyengar, Smriti, Wernicke, Joachim F.

“…This was a 12-week, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of duloxetine, a selective serotonin and…”
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Correlates of alcohol use in adults with ADHD and comorbid alcohol use disorders: exploratory analysis of a placebo-controlled trial of atomoxetine by Wilens, Timothy E., Adler, Lenard A., Tanaka, Yoko, Xiao, Feng, D'Souza, Deborah N., Gutkin, Stephen W., Upadhyaya, Himanshu P.

“…Abstract Background: Attention-deficit/hyperactivity disorder (ADHD) and substance use disorder are often comorbid in adults. The effects of ADHD treatment on…”
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A six-month double-blind, placebo-controlled, randomized clinical trial of duloxetine for the treatment of fibromyalgia by Chappell, Amy S, Bradley, Laurence A, Wiltse, Curtis, Detke, Michael J, D'Souza, Deborah N, Spaeth, Michael

“…Assess the efficacy of duloxetine 60/120 mg (N = 162) once daily compared with placebo (N = 168) in the treatment of patients with fibromyalgia, during six…”
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A double-blind, placebo-controlled study of edivoxetine as an adjunctive treatment for patients with major depressive disorder who are partial responders to selective serotonin reuptake inhibitor treatment by Ball, Susan, Dellva, Mary Anne, D'Souza, Deborah N, Marangell, Lauren B, Russell, James M, Goldberger, Celine

“…Abstract Background This phase 2 study examined the efficacy and tolerability of edivoxetine, a highly selective norepinephrine reuptake inhibitor, as an…”
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Quality of life in children and adolescents with bipolar I depression treated with olanzapine/fluoxetine combination by Walker, Daniel J, DelBello, Melissa P, Landry, John, D'Souza, Deborah N, Detke, Holland C

“…We examined the efficacy of olanzapine/fluoxetine combination (OFC) in improving health-related quality of life (QoL) in the treatment of bipolar depression in…”
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Duloxetine versus routine care in the long-term management of diabetic peripheral neuropathic pain by Raskin, Joel, Smith, Timothy R, Wong, Kar, Pritchett, Yili Lu, D'Souza, Deborah N, Iyengar, Smriti, Wernicke, J F

“…Duloxetine hydrochloride is a dual reuptake inhibitor of both serotonin and norepinephrine. In the present open-label study, the safety of duloxetine at a…”
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Characteristics of Placebo Responders in Pediatric Clinical Trials of Attention-Deficit/Hyperactivity Disorder by Newcorn, Jeffrey H., M.D, Sutton, Virginia K., Ph.D, Zhang, Shuyu, M.S, Wilens, Timothy, M.D, Kratochvil, Christopher, M.D, Emslie, Graham J., M.D, D'souza, Deborah N., Ph.D., M.B.A, Schuh, Leslie M., Ph.D, Allen, Albert J., M.D., Ph.D

“…Abstract Objective Understanding placebo response is a prerequisite to improving clinical trial methodology. Data from placebo-controlled trials of atomoxetine…”
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A randomized trial of edivoxetine in pediatric patients with attention-deficit/hyperactivity disorder by Lin, Daniel Y, Kratochvil, Christopher J, Xu, Wen, Jin, Ling, D'Souza, Deborah N, Kielbasa, William, Allen, Albert J

“…The purpose of this study was to assess the efficacy and safety of edivoxetine (LY2216684), a selective norepinephrine reuptake inhibitor, in pediatric…”
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A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia by Verstovsek, Srdan, Mesa, Ruben A., Salama, Mohamed E., Li, Li, Pitou, Celine, Nunes, Fabio P., Price, Gregory L., Giles, Jennifer L., D’Souza, Deborah N., Walgren, Richard A., Prchal, Josef T.

“…•Gandotinib shows increased potency for the JAK2V617F mutation.•The recommended phase 2 dose of 120mg was associated with clinical improvement.•Findings at the…”
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A 1-year Safety and Efficacy Study of Duloxetine in Patients With Fibromyalgia by Chappell, Amy S, Littlejohn, Geoffrey, Kajdasz, Daniel K, Scheinberg, Morton, DʼSouza, Deborah N, Moldofsky, Harvey

“…OBJECTIVESEvaluate the efficacy and safety of duloxetine at doses up to 120 mg once daily in patients with fibromyalgia. METHODSThis was a phase 3, 60-week…”
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Hepatic effects of duloxetine-I: non-clinical and clinical trial data by Wernicke, Joachim, Pangallo, Beth, Wang, Fujun, Murray, Isabelle, Henck, Judith W, Knadler, Mary Pat, D'Souza, Deborah N, Uetrecht, Jack P

“…Review nonclinical and clinical trial data for hepatic effects of duloxetine. Review studies of toxicology, metabolism, mitochondrial effects, and clinical…”
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Glycemic control after 6 days of insulin pump reservoir use in type 1 diabetes: results of double-blind and open-label cross-over trials of insulin lispro and insulin aspart by Tamborlane, William V, Renard, Eric, Wadwa, R Paul, Blevins, Thomas, Jacober, Scott J, Liu, Rong, D'Souza, Deborah N, Rees, Tina M

“…The objective of the current study was to assess mean self-monitored blood glucose (SMBG), on day 6 of 6 days of continuous reservoir wear (6D), with insulin…”
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An Open-Label 52-Week Clinical Extension Comparing Duloxetine with Routine Care in Patients with Diabetic Peripheral Neuropathic Pain by Wernicke, Joachim F., Wang, Fujun, Pritchett, Yili L., Smith, Timothy R., Raskin, Joel, D'Souza, Deborah N., Iyengar, Smriti, Chappell, Amy S.

“…ABSTRACT Objective.  To assess the safety of duloxetine at a fixed‐dose of 60 mg twice daily (BID) for up to 52 weeks, and compare duloxetine with routine care…”
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Atomoxetine Treatment Outcomes in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: Results From a Post Hoc, Pooled Analysis by Adler, Lenard A., MD, Wilens, Timothy, MD, Zhang, Shuyu, MS, Dittmann, Ralf W., MD, PhD, D'Souza, Deborah N., PhD, MBA, Schuh, Leslie, PhD, Durell, Todd M., MD

“…Abstract Background Many children with attention-deficit/hyperactivity disorder (ADHD) continue to experience this disorder as adults, which may, in part, be…”
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Duloxetine : Meta-analyses of suicidal behaviors and ideation in clinical trials for major depressive disorder by ACHARYA, Nayan, ROSEN, Amy S, POLZER, John P, D'SOUZA, Deborah N, PERAHIA, David G, CAVAZZONI, Patrizia A, BALDESSARINI, Ross J

“…Uncertainty regarding relationships of antidepressant treatment and suicidality encouraged systematic review of data on suicidal behaviors and ideation from…”
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