Search Results - "D'Souza, Cyril D."

In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia by Esterlis, Irina, Ranganathan, Mohini, Bois, Frederic, Pittman, Brian, Picciotto, Marina R, Shearer, Lara, Anticevic, Alan, Carlson, Jon, Niciu, Mark J, Cosgrove, Kelly P, D’Souza, D. Cyril

“…Background Schizophrenia is associated with very high rates of tobacco smoking. The latter may be related to an attempt to self-medicate symptoms and/or to…”
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Acute effects of THC on time perception in frequent and infrequent cannabis users by Sewell, R. Andrew, Schnakenberg, Ashley, Elander, Jacqueline, Radhakrishnan, Rajiv, Williams, Ashley, Skosnik, Patrick D., Pittman, Brian, Ranganathan, Mohini, D’Souza, D. Cyril

“…Rationale Cannabinoids have been shown to alter time perception, but existing literature has several limitations. Few studies have included both time…”
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Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists by Krystal, John H., Mathew, Sanjay J., D’Souza, D. Cyril, Garakani, Amir, Gunduz-Bruce, Handan, Charney, Dennis S.

“…Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising agents under development for the treatment of psychiatric disorders. The…”
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Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects by Krystal, John H, Abi-Saab, Walid, Perry, Edward, D'Souza, D Cyril, Liu, Nianjin, Gueorguieva, Ralitza, McDougall, Lisa, Hunsberger, Tracy, Belger, Aysenil, Levine, Louise, Breier, Alan

“…Some of the behavioral consequences of deficits in N-methyl-D-aspartate (NMDA) glutamate receptor function are thought to arise from the disinhibition of…”
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NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development by Krystal, John H, D'Souza, D Cyril, Mathalon, Daniel, Perry, Edward, Belger, Aysenil, Hoffman, Ralph

“…There is an urgent need to improve the pharmacotherapy of schizophrenia despite the introduction of important new medications. New treatment insights may come…”
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Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia by Boggs, Douglas L, Carlson, Jon, Cortes-Briones, Jose, Krystal, John H, D'Souza, D Cyril

“…Cognitive impairment is known to be a core deficit in schizophrenia. Existing treatments for schizophrenia have limited efficacy against cognitive impairment…”
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Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia by Krystal, John H., Tolin, David F., Sanacora, Gerard, Castner, Stacy A., Williams, Graham V., Aikins, Deane E., Hoffman, Ralph E., D'Souza, D. Cyril

“…Current treatments for psychiatric disorders were developed with the aim of providing symptomatic relief rather than reversing underlying abnormalities in…”
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Preliminary Findings on the Interactive Effects of IV Ethanol and IV Nicotine on Human Behavior and Cognition: A Laboratory Study by Ralevski, Elizabeth, Perry, Edward B., D’Souza, D. Cyril, Bufis, Vanessa, Elander, Jacqueline, Limoncelli, Diana, Vendetti, Michael, Dean, Erica, Cooper, Thomas B., McKee, Sherry, Petrakis, Ismene

“…There are mixed reports on nicotine's effects on alcohol-induced impairment in cognitive performance and behavior in humans. The main objective of this study…”
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The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia by Krystal, John H, D'Souza, D Cyril, Gallinat, Jürgen, Driesen, Naomi, Abi-Dargham, Anissa, Petrakis, Ismene, Heinz, Andreas, Pearlson, Godfrey

“…Individuals with schizophrenia are at increased risk for developing substance abuse disorders. Here, we consider factors that might elevate their risk for…”
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Altered NMDA Glutamate Receptor Antagonist Response in Recovering Ethanol-Dependent Patients by KRYSTAL, John H, PETRAKIS, Ismene L, LIMONCELLI, Diana, WEBB, Elizabeth, GUEORGUEVA, Ralitza, CYRIL D'SOUZA, D, BOUTROS, Nashaat N, TREVISAN, Louis, CHARNEY, Dennis S

“…Ethanol is an antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor. Ethanol dependence upregulates NMDA receptors and contributes to crosstolerance…”
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N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability by Krystal, John H, Petrakis, Ismene L, Mason, Graeme, Trevisan, Louis, D'Souza, D Cyril

“…This review takes a translational neuroscience perspective on the role of glutamate systems in human ethanol abuse and dependence. Ethanol is a simple molecule…”
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Nicotine effects on brain function and functional connectivity in schizophrenia by JACOBSEN, Leslie K, D'SOUZA, D. Cyril, MENCL, W. Einar, PUGH, Kenneth R, SKUDLARSKI, Pawel, KRYSTAL, John H

“…Nicotine in tobacco smoke can improve functioning in multiple cognitive domains. High rates of smoking among schizophrenic patients may reflect an effort to…”
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Psychiatric safety of ketamine in psychopharmacology research by PERRY, Edward B, CRAMER, Joyce A, CHO, Hyun-Sang, PETRAKIS, Ismene L, KARPER, Laurence P, GENOVESE, Angelina, O'DONNELL, Elizabeth, KRYSTAL, John H, D'SOUZA, D. Cyril

“…A growing number of investigators are studying ketamine effects in healthy human subjects, but concerns remain about its safety as a research tool. Therefore,…”
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Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine: Implications for Glutamatergic and Dopaminergic Model Psychoses and Cognitive Function by Krystal, John H, Perry, Edward B, Gueorguieva, Ralitza, Belger, Aysenil, Madonick, Steven H, Abi-Dargham, Anissa, Cooper, Thomas B, MacDougall, Lisa, Abi-Saab, Walid, D’Souza, D. Cyril

“…BACKGROUND In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous…”
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Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms by Abi-Saab, Walid, Seibyl, John P, D'Souza, D Cyril, Karper, Laurence P, Gueorgueva, Ralitza, Abi-Dargham, Anissa, Wong, Ma-Li, Rajhans, Sachin, Erdos, Joseph P, Heninger, George R, Charney, Dennis S, Krystal, John H

“…Serotonin-2 (5-HT(2)) receptor antagonism has been hypothesized to have antipsychotic activity. However, there has been limited evidence directly linking…”
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NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy by Krystal, John H, Petrakis, Ismene L, Krupitsky, Evgeny, Schutz, Christian, Trevisan, Louis, D'Souza, D Cyril

“…This paper reviews clinical evidence suggesting that antagonism of the N-methyl-D-aspartate subtype of glutamate receptors by ethanol may convey an important…”
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Effect of a Nicotine Vaccine on Nicotine Binding to β2-Nicotinic Acetylcholine Receptors In Vivo in Human Tobacco Smokers by ESTERLIS, Irina, HANNESTAD, Jonas O, PERKINS FREDERIC BOIS, Evgenia, CYRIL D'SOUZA, D, TYNDALE, Rachel F, SEIBYL, John P, HATSUKAMI, Dorothy M, COSGROVE, Kelly P, O'MALLEY, Stephanie S

“…Nicotine promotes smoking partly by binding to β2-containing nicotinic acetylcholine receptors (β2*-nAChRs) in the brain. Smoking one tobacco cigarette results…”
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Clinical significance of neurological soft signs in schizophrenia: Factor analysis of the Neurological Evaluation Scale by Sewell, R. Andrew, Perry, Edward B, Karper, Laurence P, Bell, Morris D, Lysaker, Paul, Goulet, Joseph L, Brenner, Louise, Erdos, Joseph, d'Souza, D. Cyril, Seibyl, John P, Krystal, John H

“…Abstract Background Nonlocalizing neurologic deficits detectable by clinical evaluation–“soft signs”–are a robust finding in patients diagnosed with…”
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Interactive effects of subanesthetic ketamine and haloperidol in healthy humans by KRYSTAL, J. H, D'SOUZA, D. C, CHARNEY, D. S, KARPER, L. P, BENNETT, A, ABI-DARGHAM, A, ABI-SAAB, D, CASSELLO, K, BOWERS, M. B, VEGSO, S, HENINGER, G. R

“…Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist with prominent psychoactive effects in humans. This study evaluated whether the oral…”
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Cannabinoids and Psychosis by D'Souza, Deepak Cyril, Radhakrishnan, Rajiv, Sherif, Mohamed, Cortes-Briones, Jose, Cahill, John, Gupta, Swapnil, Skosnik, Patrick D, Ranganathan, Mohini

“…There is growing interest in the relationship between cannabis and psychosis. The link between cannabis use and psychosis comprises three distinct…”
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