Search Results - "D'Orsogna, Lloyd J."

A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome by Della Mina, Erika, Jackson, Katherine J. L., Crawford, Alexander J. I., Faulks, Megan L., Pathmanandavel, Karrnan, Acquarola, Nicolino, O’Sullivan, Michael, Kerre, Tessa, Naesens, Leslie, Claes, Karlien, Goodnow, Christopher C., Haerynck, Filomeen, Kracker, Sven, Meyts, Isabelle, D’Orsogna, Lloyd J., Ma, Cindy S., Tangye, Stuart G.

“…B cells and their secreted antibodies are fundamental for host-defense against pathogens. The generation of high-affinity class switched antibodies results…”
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Allo-HLA reactivity of virus-specific memory T cells is common by Amir, Avital L, D'Orsogna, Lloyd J.A, Roelen, Dave L, van Loenen, Marleen M, Hagedoorn, Renate S, de Boer, Renate, van der Hoorn, Menno A.W.G, Kester, Michel G.D, Doxiadis, Ilias I.N, Falkenburg, J. H. Frederik, Claas, Frans H.J, Heemskerk, Mirjam H.M

“…Graft-versus-host disease and graft rejection are major complications of allogeneic HLA-mismatched stem cell transplantation or organ transplantation that are…”
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CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells by Hao, Yuwei, Miraghazadeh, Bahar, Chand, Rochna, Davies, Ainsley R., Cardinez, Chelisa, Kwong, Kristy, Downes, Morgan B., Sweet, Rebecca A., Cañete, Pablo F., D’Orsogna, Lloyd J., Fulcher, David A., Choo, Sharon, Yip, Desmond, Peters, Geoffrey, Yip, Sonia, Witney, Matthew J., Nekrasov, Maxim, Feng, Zhi-Ping, Tscharke, David C., Vinuesa, Carola G., Cook, Matthew C.

“…As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients could yield…”
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Refractory anti-phospholipid antibody syndrome treated with cyclophosphamide, resulting in a successful pregnancy by Stevenson, Brittany R, Hall, Anne E, Gupta, Ashu, Dickinson, Jan E, Graham, Dorothy F, D’Orsogna, Lloyd J

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Drug‐induced alloreactivity: A new paradigm for allorecognition by D'Orsogna, Lloyd J., Almeida, Coral‐Ann M., Miert, Paula, Zoet, Yvonne M., Anholts, Jacqueline D. H., Chopra, Abha, Watson, Mark, Witt, Campbell, John, Mina, Claas, Frans H. J.

“…Abacavir administration is associated with drug‐induced hypersensitivity reactions in HIV+ individuals expressing the HLA‐B*57:01 allele. However, the…”
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Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8 + T Cell Receptors by Rowntree, Louise C, van den Heuvel, Heleen, Sun, Jessica, D'Orsogna, Lloyd J, Nguyen, Thi H O, Claas, Frans H J, Rossjohn, Jamie, Kotsimbos, Tom C, Purcell, Anthony W, Mifsud, Nicole A

“…T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T…”
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CHAR T‐cells: Transplant immunology to (re)enter the field of personalised medicine? by D'Orsogna, Lloyd J., Holdsworth, Rhonda

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OR24 Allo-HLA reactivity by HIV-specific T-cells: A potential adjunct to HIV vaccine design? by D’Orsogna, Lloyd J, Claas, Frans H.J, John, Mina, Almeida, Coral-Ann, van Miert, Paula, Fernandez, Sonia, Zoet, Yvonne

“…Aim The rate of new HIV infections continues to be high, particularly in the developing world. An effective preventative HIV vaccine remains elusive and…”
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Drug induced alloreactivity: A new paradigm for allorecognition by D’Orsogna, Lloyd J, Claas, Frans H.J, John, Mina, Almeida, Coral-Ann, van Miert, Paula, Fernandez, Sonia, Zoet, Yvonne

“…Aim Abacavir administration is associated with drug induced hypersensitivity reactions in HIV patients expressing the HLA-B∗57:01 allele. However the…”
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Tissue Specificity of Cross-Reactive Allogeneic Responses by EBV EBNA3A-Specific Memory T Cells by D'ORSOGNA, Lloyd J. A, ROELEN, Dave L, VAN KOOTEN, Cees, DOXIADIS, Ilias I. N, CLAAS, Frans H. J, VAN DER MEER-PRINS, Ellen M. W, VAN DER POL, Pieter, FRANKE-VAN DIJK, Marry E, EIKMANS, Michael, ANHOLTS, Jacqy, ROSSJOHN, Jamie, MCCLUSKEY, James, MULDER, Arend

“…The crossreactivity of Epstein-Barr virus (EBV Epstein-Barr virus nuclear antigen 3A [EBNA3A])-specific CD8 T cells against allogeneic human leukocyte antigen…”
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Peri-operative third party red blood cell transfusion in renal transplantation and the risk of antibody-mediated rejection and graft loss by Fidler, Samantha, Swaminathan, Ramyasuda, Lim, Wai, Ferrari, Paolo, Witt, Campbell, Christiansen, Frank T, D'Orsogna, Lloyd J, Irish, Ashley B

“…Abstract Historic red blood cell transfusion (RBCT) may induce anti-HLA antibody which, if donor specific (DSA), is associated with increased antibody-mediated…”
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Stimulation of human EBV- and CMV-specific cytolytic effector function using allogeneic HLA molecules by D'Orsogna, Lloyd J, van den Heuvel, Heleen, van der Meer-Prins, Ellen M W, Roelen, Dave L, Doxiadis, Ilias I N, Claas, Frans H J

“…Viral infection is a major cause of morbidity and mortality, and there are few therapeutic options available to augment a virus-specific T cell response…”
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Vaccine-Induced Allo-HLA―Reactive Memory T Cells in a Kidney Transplantation Candidate by D'ORSOGNA, Lloyd J. A, VAN BESOUW, Nicole M, ROELEN, Dave L, DOXIADIS, Ilias I. N, CLAAS, Frans H. J, VAN DER MEER-PRINS, Ellen M. W, VAN DER POL, Pieter, FRANKE-VAN DIJK, Marry, ZOET, Yvonne M, VAN DER SLIK, Arno, WEIMAR, Willem, VAN KOOTEN, Cees, MULDER, Arend

“…Allo-human leukocyte antigen (HLA) reactivity by naturally acquired viral-specific memory T cells is common. However, the effect of successful vaccination on…”
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Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection by LIM, Andrew, AMINI, Afsana, D'ORSOGNA, Lloyd J, RAJASURIAR, Reena, KRAMSKI, Marit, LEWIN, Sharon R, PURCELL, Damian F, PRICE, Patricia, FRENCH, Martyn A

“…To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in…”
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Different eplet software programs give discordant and incorrect results: An analysis of HLAMatchmaker vs Fusion Matchmaker Eplet calling software by Tassone, Gabriella, De Santis, Dianne, Vukovic, Irena, Downing, Jonathan, Martinez, Olga Patricia, D'Orsogna, Lloyd J.

“…HLA eplet matching is a novel approach to define acceptable HLA mismatches for transplant recipients. We performed an eplet analysis of three different…”
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C3d‐binding assay for the detection of complement activating HLA antibodies: A useful tool for allocation to highly sensitised recipients in the post‐CDC era? by Wong, Zo Ee, Downing, Jonathan, De Santis, Dianne, Halse, Megan, Bruce, Samuel, Truong, Linh, Martinez, Patricia, D'Orsogna, Lloyd J.

“…The CDC crossmatch test is being phased out in solid organ donor allocation, and standard luminex single antigen bead assays do not differentiate complement…”
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A novel allocation strategy for the difficult‐to‐allocate donor: audit of deceased donor kidneys utilised for preemptive recipients within Western Australia by Kulkarni, Rishabh, Wong, Zo E., Downing, Jonathan, Swaminathan, Ramyasuda, Chan, Doris, Chakera, Aron, Abraham, Abu, Irish, Ashley, Lim, Wai, D'Orsogna, Lloyd J.

“…Kidney donor allocation can occasionally be difficult in Australia given a small population spread over vast distances. Therefore, between 2017 and 2019 our…”
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A Novel Targeted Amplicon Next-Generation Sequencing Gene Panel for the Diagnosis of Common Variable Immunodeficiency Has a High Diagnostic Yield: Results from the Perth CVID Cohort Study by Kermode, William, De Santis, Dianne, Truong, Linh, Della Mina, Erika, Salman, Sam, Thompson, Grace, Nolan, David, Loh, Richard, Mallon, Dominic, Mclean-Tooke, Andrew, John, Mina, Tangye, Stuart G, O'Sullivan, Michael, D'Orsogna, Lloyd J

“…With the advent of next-generation sequencing (NGS), monogenic forms of common variable immunodeficiency (CVID) have been increasingly described. Our study…”
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Virus-specific T-cell clonotypes might contribute to drug hypersensitivity reactions through heterologous immunity by Almeida, Coral-Ann, van Miert, Paula, O'Driscoll, Kane, Zoet, Yvonne M., Chopra, Abha, Witt, Campbell, John, Mina, Claas, Frans H.J., D'Orsogna, Lloyd J.

“…Multiple HIV-specific TW10/HLA-B57– and KF11/HLA-B57–restricted CD8 T-cell clones were generated from 4 different HIV-seropositive, abacavir treatment–naive…”
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Public T cell clonotypes are selected in HLA-B∗57:01+/HIV+ patients independently of the viral load by Chatzileontiadou, Demetra S.M., Lobos, Christian A., Robson, Hayden, Almedia, Coral-Ann, Szeto, Christopher, Castley, Alison, D’Orsogna, Lloyd J., Gras, Stephanie

“…HIV controllers can control viral replication and remain healthy, but the mechanism behind this control is unknown. Despite human leukocyte antigen (HLA)…”
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