Search Results - "D'ERCOLE, A. J"

Social approach in genetically engineered mouse lines relevant to autism by Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Grossman, A. W., Murphy, D. L., D’Ercole, A. J., Crawley, J. N., Magnuson, T. R., Lauder, J. M.

“…Profound impairment in social interaction is a core symptom of autism, a severe neurodevelopmental disorder. Deficits can include a lack of interest in social…”
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Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination by Mason, J. L, Ye, P, Suzuki, K, D'Ercole, A. J, Matsushima, G. K

“…Metabolic insult results in apoptosis and depletion of mature oligodendrocytes during demyelination. To examine the role of insulin-like growth factor-1…”
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Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development by O'Kusky, John R, Ye, Ping, D'Ercole, A. Joseph

“…The in vivo actions of insulin-like growth factor-I (IGF-I) on the growth and development of the hippocampal dentate gyrus were investigated in transgenic mice…”
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Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I by Ohneda, K, Ulshen, MH, Fuller, CR, D'Ercole, AJ, Lund, PK

“…BACKGROUND & AIMS: Growth hormone and insulin-like growth factor I (IGF- I) stimulate small bowel growth. The aim of this study was to analyze whether IGF-I…”
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Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth by Simmons, J G, Ling, Y, Wilkins, H, Fuller, C R, D'Ercole, A J, Fagin, James, Lund, P K

“…Insulin-like growth factor I (IGF-I) potently stimulates intestinal growth. Insulin receptor substrate-1 (IRS-1) mediates proliferative and antiapoptotic…”
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In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice by Ye, P, Carson, J, D'Ercole, AJ

“…To study the effects and mechanisms of insulin-like growth factor I (IGF-I) on brain myelination in vivo, the morphology of myelinated axons and the expression…”
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Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues by Lund, P K, Moats-Staats, B M, Hynes, M A, Simmons, J G, Jansen, M, D'Ercole, A J, Van Wyk, J J

“…Somatomedin-C or insulin-like growth factor I (Sm-C/IGF-I) and insulin-like growth factor II (IGF-II) have been implicated in the regulation of fetal growth…”
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Sexual Development in a Two-Year-Old Boy Induced by Topical Exposure to Testosterone by Yu, Y. Miles, Punyasavatsu, Natavut, Elder, Deborah, D'Ercole, A. Joseph

“…Virilization, including penile enlargement and growth of pubic hair and facial acne, developed in a 2-year-old boy over a period of months. This sexual…”
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Mechanisms of in utero overgrowth by D'Ercole, AJ

“…D'Ercole AJ. Mechanisms of in utero overgrowth. Acta Pædiatr 1999; Suppl 428: 31–6. Stockholm. ISSN 0803–5326 Determination of the mechanisms that lead to in…”
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Tissue Concentrations of Somatomedin C: Further Evidence for Multiple Sites of Synthesis and Paracrine or Autocrine Mechanisms of Action by D'Ercole, A. Joseph, Stiles, Alan D., Underwood, Louis E.

“…We have validated a method for extracting and measuring the tissue content of somatomedin C (Sm-C)/insulin-like growth factor I (IGF-I), a…”
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Insulin-like growth factor-I influences the initiation of myelination: studies of the anterior commissure of transgenic mice by Ye, P., Carson, J., D'Ercole, A.J.

“…The effects of insulin-like growth factor-I (IGF-I) on the initiation of myelination have been examined in the posterior portion of anterior commissure of the…”
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Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus by Victor K. M. Han, D'Ercole, A. Joseph, Lund, P. Kay

“…The somatomedins or insulin-like growth factors (IGFs) are synthesized in many organs and tissues, but the specific cells that synthesize them in vivo have not…”
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Insulin-Like Growth Factor I Protects Oligodendrocytes from Tumor Necrosis Factor-α-Induced Injury by Ye, P., D’Ercole, A. J.

“…Abstract Tumor necrosis factor-α (TNF-α) has been causally implicated in several demyelinating disorders, including multiple sclerosis. Because insulin-like…”
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Hepatic mRNAs up‐regulated by starvation: an expression profile determined by suppression subtractive hybridization by Zhang, Jihui, Underwood, Louis E., D'Ercole, A. Joseph

“…ABSTRACT Delineating the molecular basis for the metabolic switch from the well‐fed state to starvation is crucial to understanding nutritionally regulated…”
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Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-alpha-induced injury by Ye, P, D'Ercole, A J

“…Tumor necrosis factor-alpha (TNF-alpha) has been causally implicated in several demyelinating disorders, including multiple sclerosis. Because insulin-like…”
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Insulin-like growth factor-I (IGF-I) ameliorates and IGF binding protein-1 (IGFBP-1) exacerbates the effects of undernutrition on brain growth during early postnatal life : Studies in IGF-I and IGFBP-1 transgenic mice by LEE, K.-H, CALIKOGLU, A. S, PING YE, D'ERCOLE, A. J

“…Insulin-like growth factor-I (IGF-I) plays an important role in the stimulation of postnatal brain growth. In transgenic (Tg) mice, IGF-I overexpression…”
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Myelination Is Altered in Insulin-Like Growth Factor-I Null Mutant Mice by Ye, Ping, Li, Liqin, Richards, R. Gregg, DiAugustine, Richard P, D'Ercole, A. Joseph

“…Increasing evidence indicates that insulin-like growth factor-I (IGF-I) has an important role in oligodendrocyte development. In this study, we examined…”
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In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system by Popken, Gregory J., Hodge, Rebecca D., Ye, Ping, Zhang, Jihui, Ng, Winnie, O'Kusky, John R., D'Ercole, A. Joseph

“…The in vivo actions of insulin‐like growth factor‐I (IGF‐I) on prenatal and early postnatal brain development were investigated in transgenic (Tg) mice that…”
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Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I by CLEMMONS, D. R, ELGIN, R. G, HAN, V. K. M, CASELLA, S. J, D'ERCOLE, A. J, VAN WYK, J. J

“…We studied somatomedin-C/insulinlike growth factor (Sm-C/IGF-I) binding to human fibroblasts in both adherent monolayers and in suspension cultures. The…”
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Insulin-Like Growth Factor-I Overexpression Attenuates Cerebellar Apoptosis by Altering the Expression of Bcl Family Proteins in a Developmentally Specific Manner by Chrysis, Dionisios, Calikoglu, Ali Suha, Ye, Ping, D'Ercole, A. Joseph

“…In studies of transgenic (Tg) mice that overexpress insulin-like growth factor-I (IGF-I) exclusively in the CNS, we demonstrated a dramatic increase in…”
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