Search Results - "D'Costa, Zenobia C"

BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers by Buckley, Niamh E, Nic An tSaoir, Caoimhe B, Blayney, Jaine K, Oram, Lisa C, Crawford, Nyree T, D'Costa, Zenobia C, Quinn, Jennifer E, Kennedy, Richard D, Harkin, D Paul, Mullan, Paul B

“…Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch pathway in breast cells by…”
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TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities by D'Costa, Zenobia C, Higgins, Catherine, Ong, Chee Wee, Irwin, Gareth W, Boyle, David, McArt, Darragh G, McCloskey, Karen, Buckley, Niamh E, Crawford, Nyree T, Thiagarajan, Lalitha, Murray, James T, Kennedy, Richard D, Mulligan, Karl A, Harkin, D Paul, Waugh, David J J, Scott, Chris J, Salto-Tellez, Manuel, Williams, Richard, Mullan, Paul B

“…TBX2 is an oncogenic transcription factor known to drive breast cancer proliferation. We have identified the cysteine protease inhibitor Cystatin 6 (CST6) as a…”
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