Search Results - "D'Costa, D. F."

Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity by Costa, Márcia F. D., Rösler, Thomas W., Höglinger, Günter U.

“…Modulation of the Nrf2 pathway, a master regulator of the antioxidant response and cellular metabolism, has been suggested as a promising therapeutic strategy…”
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Development of a cell-free screening assay for the identification of direct PERK activators by Costa, Márcia F D, Höglinger, Günter U, Rösler, Thomas W

“…The activation of the unfolded protein response, particularly via the PERK pathway, has been suggested as a promising therapeutic approach in tauopathies, a…”
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Study of the Chlorine Influence on the Corrosion of Three Steels to Be Used in Water Treatment Municipal Facilities by Costa, Rúben D F S, Barbosa, Marta L S, Silva, Francisco J G, Sousa, Susana R, Sousa, Vitor F C, Ferreira, Bruno O

“…Many municipal facilities, such as pools and drinking water treatment facilities, are subject to ongoing maintenance due to the corrosion of their metallic…”
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PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer by Costa, Tânia D. F., Zhuang, Ting, Lorent, Julie, Turco, Emilia, Olofsson, Helene, Masia-Balague, Miriam, Zhao, Miao, Rabieifar, Parisa, Robertson, Neil, Kuiper, Raoul, Sjölund, Jonas, Spiess, Matthias, Hernández-Varas, Pablo, Rabenhorst, Uta, Roswall, Pernilla, Ma, Ran, Gong, Xiaowei, Hartman, Johan, Pietras, Kristian, Adams, Peter D., Defilippi, Paola, Strömblad, Staffan

“…Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all…”
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Investigations on the Surface Integrity and Wear Mechanisms of TiAlYN-Coated Tools in Inconel 718 Milling Operations by Silva, Francisco J G, Sebbe, Naiara P V, Costa, Rúben D F S, Pedroso, André F V, Sales-Contini, Rita C M, Barbosa, Marta L S, Martinho, Rui P

“…Inconel 718 is a Ni superalloy with superior mechanical properties, even at high temperatures. However, due to its high hardness and low thermal conductivity,…”
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The Impact of the Deterioration on Wood by Chlorine: An Experimental Study by Costa, Rúben D F S, Barbosa, Marta L S, Silva, Francisco J G, Sousa, Susana R, Pinto, Arnaldo G, Sousa, Vitor F C, Ferreira, Bruno O

“…The use of disinfection and cleaning chemicals in several municipal facilities, such as swimming pools and drinking water treatment plants, causes the…”
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Studying the Degradation of Three Polymers under Different Chlorine Concentrations and Exposure Times by Barbosa, Marta L. S., Costa, Rúben D. F. S., Silva, Francisco J. G., Sousa, Susana R., Pinto, Arnaldo G., Ferreira, Bruno O.

“…Due to chlorine’s ability to kill bacteria and fungi through a chemical reaction, chlorine solutions are commonly used to clean and disinfect numerous public…”
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A Critical Review on Fiber Metal Laminates (FML): From Manufacturing to Sustainable Processing by Costa, Rúben D. F. S., Sales-Contini, Rita C. M., Silva, Francisco J. G., Sebbe, Naiara, Jesus, Abílio M. P.

“…Composite materials such as Fiber Metal Laminates (FMLs) have attracted the interest of the aerospace and automotive industries due to their high strength to…”
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Wear Behavior Phenomena of TiN/TiAlN HiPIMS PVD-Coated Tools on Milling Inconel 718 by Sousa, Vitor F. C., Fernandes, Filipe, Silva, Francisco J. G., Costa, Rúben D. F. S., Sebbe, Naiara, Sales-Contini, Rita C. M.

“…Due to Inconel 718’s high mechanical properties, even at higher temperatures, tendency to work-harden, and low thermal conductivity, this alloy is considered…”
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Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion by Rabieifar, Parisa, Zhuang, Ting, Costa, Tânia D. F., Zhao, Miao, Strömblad, Staffan

“…p21-activated kinases (PAKs) are serine/threonine kinases functioning as downstream effectors of the small GTPases Rac1 and Cdc42. Members of the PAK family…”
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Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development by Zhao, Miao, Rabieifar, Parisa, Costa, Tânia D. F., Zhuang, Ting, Minden, Audrey, Löhr, Matthias, Heuchel, Rainer, Strömblad, Staffan

“…Constitutive depletion of p21-activated kinase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defects. Given that…”
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SELNET clinical practice guidelines for bone sarcoma by Blay, JY, Palmerini, E., Bollard, J., Aguiar, S., Angel, M., Araya, B., Badilla, R., Bernabeu, D., Campos, F., CHS, Caro-Sánchez, Carvajal Montoya, A., Casavilca-Zambrano, S., Castro-Oliden, Chacón, M., Clara-Altamirano, MA, Collini, P., Correa Genoroso, R., Costa, FD, Cuellar, M., dei Tos, AP, Dominguez Malagon, HR, Donati, DM, Dufresne, A., Eriksson, M., Farias-Loza, M., Frezza, AM, Frisoni, T., Garcia-Ortega, DY, Gerderblom, H., Gouin, F., Gómez-Mateo, MC, Gronchi, A., Haro, J., Hindi, N., Huanca, L., Jimenez, N., Karanian, M., Kasper, B., Lopes, A., Lopes David, BB, Lopez-Pousa, A., Lutter, G., Maki, RG, Martinez-Said, H., Martinez-Tlahuel, JL, Mello, CA, Morales Pérez, JM, Moura, DS, Nakagawa, SA, Nascimento, AG, Ortiz-Cruz, EJ, Patel, S., Pfluger, Y., Provenzano, S., Righi, A., Rodriguez, A., Santos, TG, Scotlandi, K., MLG, Silva, Soulé, T., Stacchiotti, S., Valverde, CM, Waisberg, F., Zamora Estrada, E., Martin-Broto, J.

“…Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with…”
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A Concise Review on Materials for Injection Moulds and Their Conventional and Non-Conventional Machining Processes by Pedroso, André F. V., Sebbe, Naiara P. V., Silva, Francisco J. G., Campilho, Raul D. S. G., Sales-Contini, Rita C. M., Costa, Rúben D. F. S., Barbosa, Marta L. S., Nogueira, Francisca R.

“…Injection moulds are crucial to produce plastic and lightweight metal components. One primary associated challenge is that these may suffer from different…”
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INCONEL® Alloy Machining and Tool Wear Finite Element Analysis Assessment: An Extended Review by Pedroso, André F. V., Sebbe, Naiara P. V., Costa, Rúben D. F. S., Barbosa, Marta L. S., Sales-Contini, Rita C. M., Silva, Francisco J. G., Campilho, Raul D. S. G., de Jesus, Abílio M. P.

“…Machining INCONEL® presents significant challenges in predicting its behaviour, and a comprehensive experimental assessment of its machinability is costly and…”
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R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability by Jackson, S R, Costa, M F D M, Pastore, C F, Zhao, G, Weiner, A I, Adams, S, Palashikar, G, Quansah, K, Hankenson, K, Herbert, D R, Vaughan, A E

“…R-spondin 2 (RSPO2) is required for lung morphogenesis, activates Wnt signaling, and is upregulated in idiopathic lung fibrosis. Our objective was to…”
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New control of the senescence barrier in breast cancer by Costa, Tânia D. F., Strömblad, Staffan

“…Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a…”
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Automated evaluation of the effect of ionic liquids on catalase activity by Pinto, Paula C.A.G., Costa, Andreia D.F., Lima, José L.F.C., Saraiva, M. Lúcia M.F.S.

“…► We developed an SIA assay for the assessment of ionic liquid’s effect on catalase. ► Seven ionic liquids presenting significant structural differences were…”
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Environmental Variability and Cyanobacterial Blooms in a Subtropical Coastal Lagoon: Searching for a Sign of Climate Change Effects by de Souza, Márcio S, Muelbert, José H, Costa, Luiza D F, Klering, Eliana V, Yunes, João S

“…Cyanobacterial blooms in marine and freshwater environments may be favored by shifts in physical water column parameters due to warming under climate change…”
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The Levodopa Test in Parkinson's Disease by D'COSTA, D. F., SHEEHAN, L. J., PHILLIPS, P. A., MOORE-SMITH, B.

“…The clinical diagnosis of Parkinson's disease may be difficult. In elderly patients there may be other causes of the triad of rigidity, bradykinesia and…”
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Sweet Taste Receptor Gene and Caries Trajectory in the Life Course by Chisini, L.A., Costa, F.D.S., Horta, B.L., Tovo-Rodrigues, L., Demarco, F.F., Correa, M.B.

“…This study aims to investigate whether the trajectory of dental caries in the life course is associated with rs307355 (TAS1R3) and rs35874116 (TAS1R2) and if…”
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