Search Results - "D'Assoro, A B"

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells by D'Assoro, A B, liu, T, Quatraro, C, Amato, A, Opyrchal, M, Leontovich, A, Ikeda, Y, Ohmine, S, Lingle, W, Suman, V, Ecsedy, J, Iankov, I, Di Leonardo, A, Ayers-Inglers, J, Degnim, A, Billadeau, D, McCubrey, J, Ingle, J, Salisbury, J L, Galanis, E

“…In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that…”
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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention by McCubrey, J A, Steelman, L S, Bertrand, F E, Davis, N M, Abrams, S L, Montalto, G, D'Assoro, A B, Libra, M, Nicoletti, F, Maestro, R, Basecke, J, Cocco, L, Cervello, M, Martelli, A M

“…Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat…”
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Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes by Daniel, A R, Gaviglio, A L, Knutson, T P, Ostrander, J H, D'Assoro, A B, Ravindranathan, P, Peng, Y, Raj, G V, Yee, D, Lange, C A

“…Progesterone and estrogen are important drivers of breast cancer proliferation. Herein, we probed estrogen receptor-α (ER) and progesterone receptor (PR)…”
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The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ER[α.sup.+] breast cancer cells by D'Assoro, A.B, liu, T, Quatraro, C, Amato, A, Opyrchal, M, Leontovich, A, Ikeda, Y, Ohmine, S, Lingle, W, Suman, V, Ecsedy, J, Iankov, I, Leonardo, A. Di, Ayers-Ringler, J, Degnim, A, Billadeau, D, McCubrey, J, Ingle, J, Salisbury, J.L, Galanis, E

“…In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that…”
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Impaired p53 function leads to centrosome amplification, acquired ERα phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts by D'Assoro, A B, Busby, R, Acu, I D, Quatraro, C, Reinholz, M M, Farrugia, D J, Schroeder, M A, Allen, C, Stivala, F, Galanis, E, Salisbury, J L

“…In this study, we establish an MCF-7 xenograft model that mimics the progression of human breast carcinomas typified by loss of p53 integrity, development of…”
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Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy by Iankov, I D, Kurokawa, C B, D'Assoro, A B, Ingle, J N, Domingo-Musibay, E, Allen, C, Crosby, C M, Nair, A A, Liu, M C, Aderca, I, Federspiel, M J, Galanis, E

“…Oncolytic measles virus (MV) strains have demonstrated broad spectrum preclinical anti-tumor efficacy, including breast cancer. Aurora A kinase controls…”
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GFP-centrin as a marker for centriole dynamics in the human breast cancer cell line MCF-7 by D'Assoro, A B, Stivala, F, Barrett, S, Ferrigno, G, Salisbury, J L

“…Centrosome duplication plays an important role in genomic stability through bipolar spindle formation and equal chromosome segregation during mitosis. Defects…”
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Impaired p53 function leads to centrosome amplification, acquired ERa phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts by D'ASSORO, A. B, BUSBY, R, SALISBURY, J. L, ACU, I. D, QUATRARO, C, REINHOLZ, M. M, FARRUGIA, D. J, SCHROEDER, M. A, ALLEN, C, STIVALA, F, GALANIS, E

“…In this study, we establish an MCF-7 xenograft model that mimics the progression of human breast carcinomas typified by loss of p53 integrity, development of…”
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Roles of Notch Signaling in the Tumor Microenvironment by D'Assoro, Antonino B, Leon-Ferre, Roberto, Braune, Eike-Benjamin, Lendahl, Urban

“…The Notch signaling pathway is an architecturally simple signaling mechanism, well known for its role in cell fate regulation during organ development and in…”
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Multifaceted roles of GSK-3 and Wnt/[beta]-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention by Mccubrey, J A, Steelman, L S, Bertrand, F E, Davis, N M, Abrams, S L, Montalto, G, D'assoro, A B, Libra, M, Nicoletti, F, Maestro, R, Basecke, J, Cocco, L, Cervello, M, Martelli, A M

“…Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat…”
Get full text

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ER alpha super(+) breast cancer cells by D'Assoro, A B, liu, T, Quatraro, C, Amato, A, Opyrchal, M, Leontovich, A, Ikeda, Y, Ohmine, S, Lingle, W, Suman, V, Ecsedy, J, Iankov, I, Di Leonardo, A, Ayers-Inglers, J, Degnim, A, Billadeau, D, McCubrey, J, Ingle, J, Salisbury, J L, Galanis, E

“…In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that…”
Get full text

Identification of a Notch transcriptomic signature for breast cancer by Braune, Eike-Benjamin, Geist, Felix, Tang, Xiaojia, Kalari, Krishna, Boughey, Judy, Wang, Liewei, Leon-Ferre, Roberto A, D'Assoro, Antonino B, Ingle, James N, Goetz, Matthew P, Kreis, Julian, Wang, Kang, Foukakis, Theodoros, Seshire, Anita, Wienke, Dirk, Lendahl, Urban

“…Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast…”
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Blockade of tumor cell-intrinsic PD-L1 signaling enhances AURKA-targeted therapy in triple negative breast cancer by Takchi, Andrew, Zhang, Minzhi, Jalalirad, Mohammad, Ferre, Roberto Leon, Shrestha, Royal, Haddad, Tufia, Sarkaria, Jann, Tuma, Ann, Carter, Jodi, David, Hillman, Giridhar, Karthik, Wang, Liewei, Lange, Carol, Lendahl, Urban, Ingle, James, Goetz, Matthew, D'Assoro, Antonino Bonaventura

“…Triple negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and mainly affects pre-menopausal and minority women. Because of the lack of ER,…”
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Impaired p53 function leads to centrosome amplification, acquired ER[alpha] phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts by D'assoro, A B, Busby, R, Acu, I D, Quatraro, C, Reinholz, M M, Farrugia, D J, Schroeder, M A, Allen, C, Stivala, F, Galanis, E, Salisbury, J L

“…In this study, we establish an MCF-7 xenograft model that mimics the progression of human breast carcinomas typified by loss of p53 integrity, development of…”
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Abstract P6-13-04: A phase I trial to evaluate the safety of the addition of alisertib to fulvestrant in hormone receptor positive (HR+), advanced breast cancer by Haddad, TC, D'Assoro, AB, Suman, VJ, Opyrchal, M, Goetz, MP, Ingle, JN

“…Abstract Background: During tumor progression, activation of Aurora A kinase (AURKA) is associated with epithelial to mesenchymal transition (EMT)…”
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Abstract P2-09-07: Inhibition of aurora-A by MLN8237 decreases SMAD5 expression and increases effectiveness of chemotherapeutic agents in breast cancer cells by Opyrchal, M, Iankov, I, Ingle, JN, Galanis, E, D'Assoro, AB

“…Abstract BACKGROUND: Breast cancer affects thousands of women each year. Epithelial to Mesenchymal transition (EMT) has been associated with increased…”
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Centrosome amplification and the development of cancer by D'Assoro, Antonino B, Lingle, Wilma L, Salisbury, Jeffrey L

“…ONCOGENE: (2002) 21, 6146-6153. doi:10.1038/sj.onc.1205772…”
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Centrosome Amplification Drives Chromosomal Instability in Breast Tumor Development by Lingle, Wilma L., Barrett, Susan L., Negron, Vivian C., D'Assoro, Antonino B., Boeneman, Kelly, Liu, Wanguo, Whitehead, Clark M., Reynolds, Carol, Salisbury, Jeffrey L.

“…Earlier studies of invasive breast tumors have shown that 60-80% are aneuploid and ≈80% exhibit amplified centrosomes. In this study, we investigated the…”
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Centrosome amplification and the origin of chromosomal instability in breast cancer by Salisbury, Jeffrey L, D'Assoro, Antonino B, Lingle, Wilma L

“…The development and progression of aggressive breast cancer is characterized by genomic instability leading to multiple genetic defects, phenotypic diversity,…”
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Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1 S cell cycle checkpoint by D'ASSORO, Antonino B, BUSBY, Robert, SALISBURY, Jeffrey L, SUINO, Kelly, DELVA, Emmanuella, ALMODOVAR-MERCADO, Gustavo J, JOHNSON, Heidi, FOLK, Christopher, FARRUGIA, Daniel J, VASILE, Vlad, STIVALA, Franca

“…Centrosome amplification plays a key role in the origin of chromosomal instability during cancer development and progression. In this study, breast cancer cell…”
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