Search Results - "D'Andrea, Richard J"

Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence by Duy, Cihangir, Li, Meng, Teater, Matt, Meydan, Cem, Garrett-Bakelman, Francine E, Lee, Tak C, Chin, Christopher R, Durmaz, Ceyda, Kawabata, Kimihito C, Dhimolea, Eugen, Mitsiades, Constantine S, Doehner, Hartmut, D'Andrea, Richard J, Becker, Michael W, Paietta, Elisabeth M, Mason, Christopher E, Carroll, Martin, Melnick, Ari M

“…Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we…”
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Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer by Singhal, Deepak, Hahn, Christopher N., Feurstein, Simone, Wee, Li Yan A., Moma, Luke, Kutyna, Monika M., Chhetri, Rakchha, Eshraghi, Leila, Schreiber, Andreas W., Feng, Jinghua, Wang, Paul P-S., Babic, Milena, Parker, Wendy T., Gao, Song, Moore, Sarah, Das, Soma, Thomas, David, Pattnaik, Swetansu, Brown, Anna L., D’Andrea, Richard J., Poplawski, Nicola K., Thomas, Daniel, Scott, Hamish S., Godley, Lucy A., Hiwase, Devendra K.

“…The majority of studies assessing the contribution of pathogenic germline variants (PGVs) to cancer predisposition have focused on patients with single…”
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Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia by Li, Sheng, Garrett-Bakelman, Francine E, Chung, Stephen S, Sanders, Mathijs A, Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L, Perl, Alexander E, Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D, To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L, Hassane, Duane C, Roboz, Gail J, Grimwade, David, Valk, Peter J M, D'Andrea, Richard J, Carroll, Martin, Park, Christopher Y, Neuberg, Donna, Levine, Ross, Melnick, Ari M, Mason, Christopher E

“…Genome-wide methylome sequencing of serial samples obtained from patients with acute myeloid leukemia reveals that epigenetic alleles and genetic alleles…”
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The mutational burden of therapy-related myeloid neoplasms is similar to primary myelodysplastic syndrome but has a distinctive distribution by Singhal, Deepak, Wee, Li Yan A., Kutyna, Monika M., Chhetri, Rakchha, Geoghegan, Joel, Schreiber, Andreas W., Feng, Jinghua, Wang, Paul P.-S., Babic, Milena, Parker, Wendy T., Hiwase, Smita, Edwards, Suzanne, Moore, Sarah, Branford, Susan, Kuzmanovic, Teodora, Singhal, Nimit, Gowda, Raghu, Brown, Anna L., Arts, Peer, To, Luen B., Bardy, Peter G., Lewis, Ian D., D’Andrea, Richard J., Maciejewski, Jaroslaw P., Scott, Hamish S., Hahn, Christopher N., Hiwase, Devendra K.

“…Therapy-related myeloid neoplasms (T-MN) are poorly characterized secondary hematological malignancies following chemotherapy/radiotherapy exposure. We…”
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia by Powell, Jason A., Lewis, Alexander C., Zhu, Wenying, Toubia, John, Pitman, Melissa R., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Iarossi, Diana, Samaraweera, Saumya E., Cummings, Nik, Ramshaw, Hayley S., Thomas, Daniel, Wei, Andrew H., Lopez, Angel F., D'Andrea, Richard J., Lewis, Ian D., Pitson, Stuart M.

“…Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall…”
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Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML by Hassan, Nunki, Yi, Hangyu, Malik, Bilal, Gaspard-Boulinc, Lucie, Samaraweera, Saumya E., Casolari, Debora A., Seneviratne, Janith, Balachandran, Anushree, Chew, Tracy, Duly, Alastair, Carter, Daniel R., Cheung, Belamy B., Norris, Murray, Haber, Michelle, Kavallaris, Maria, Marshall, Glenn M., Zhang, Xu Dong, Liu, Tao, Wang, Jianlong, Liebermann, Dan A., D’Andrea, Richard J., Wang, Jenny Y.

“…•GADD45A loss has a dual role in promoting DNA damage while upregulating antioxidants to sustain low ROS essential to safeguard self-renewal.•Deletion of…”
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Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia by Bassal, Mahmoud A., Samaraweera, Saumya E., Lim, Kelly, Benard, Brooks A., Bailey, Sheree, Kaur, Satinder, Leo, Paul, Toubia, John, Thompson-Peach, Chloe, Nguyen, Tran, Maung, Kyaw Ze Ya, Casolari, Debora A., Iarossi, Diana G., Pagani, Ilaria S., Powell, Jason, Pitson, Stuart, Natera, Siria, Roessner, Ute, Lewis, Ian D., Brown, Anna L., Tenen, Daniel G., Robinson, Nirmal, Ross, David M., Majeti, Ravindra, Gonda, Thomas J., Thomas, Daniel, D’Andrea, Richard J.

“…The interaction of germline variation and somatic cancer driver mutations is under-investigated. Here we describe the genomic mitochondrial landscape in adult…”
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Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies by Lewinsohn, Maya, Brown, Anna L., Weinel, Luke M., Phung, Connie, Rafidi, George, Lee, Ming K., Schreiber, Andreas W., Feng, Jinghua, Babic, Milena, Chong, Chan-Eng, Lee, Young, Yong, Agnes, Suthers, Graeme K., Poplawski, Nicola, Altree, Meryl, Phillips, Kerry, Jaensch, Louise, Fine, Miriam, D'Andrea, Richard J., Lewis, Ian D., Medeiros, Bruno C., Pollyea, Daniel A., King, Mary-Claire, Walsh, Tom, Keel, Siobán, Shimamura, Akiko, Godley, Lucy A., Hahn, Christopher N., Churpek, Jane E., Scott, Hamish S.

“…Recently our group and others have identified DDX41 mutations both as germ line and acquired somatic mutations in families with multiple cases of late onset…”
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IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation by Hong, Lih En, Wechalekar, Mihir D., Kutyna, Monika, Small, Annabelle, Lim, Kelly, Thompson-Peach, Chloe, Li, Joule J., Chhetri, Rakchha, Scott, Hamish S., Brown, Anna, Hahn, Christopher N., Yeung, David T., Sajid, Salvia, Robinson, Nirmal, Thomas, Ranjeny, Branford, Susan, D’Andrea, Richard J., Samaraweera, Saumya E., Patnaik, Mrinal, Proudman, Susanna, Thomas, Daniel, Kok, Chung Hoow, Shah, Mithun V., Hiwase, Devendra K.

“…High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity,…”
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Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia by Scott, Hamish S, Hahn, Christopher N, Chong, Chan-Eng, Carmichael, Catherine L, Wilkins, Ella J, Brautigan, Peter J, Li, Xiao-Chun, Babic, Milena, Lin, Ming, Carmagnac, Amandine, Lee, Young K, Kok, Chung H, Gagliardi, Lucia, Friend, Kathryn L, Ekert, Paul G, Butcher, Carolyn M, Brown, Anna L, Lewis, Ian D, To, L Bik, Timms, Andrew E, Storek, Jan, Moore, Sarah, Altree, Meryl, Escher, Robert, Bardy, Peter G, Suthers, Graeme K, D'Andrea, Richard J, Horwitz, Marshall S

“…We report the discovery of GATA2 as a new myelodysplastic syndrome (MDS)-acute myeloid leukemia (AML) predisposition gene. We found the same, previously…”
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Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia by Conn, Vanessa M., Gabryelska, Marta, Toubia, John, Kirk, Kirsty, Gantley, Laura, Powell, Jason A., Cildir, Gökhan, Marri, Shashikanth, Liu, Ryan, Stringer, Brett W., Townley, Scott, Webb, Stuart T., Lin, He, Samaraweera, Saumya E., Bailey, Sheree, Moore, Andrew S., Maybury, Mellissa, Liu, Dawei, Colella, Alex D., Chataway, Timothy, Wallington-Gates, Craig T., Walters, Lucie, Sibbons, Jane, Selth, Luke A., Tergaonkar, Vinay, D’Andrea, Richard J., Pitson, Stuart M., Goodall, Gregory J., Conn, Simon J.

“…The first step of oncogenesis is the acquisition of a repertoire of genetic mutations to initiate and sustain the malignancy. An important example of this…”
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Childhood acute myeloid leukemia shows a high level of germline predisposition by Samaraweera, Saumya E., Wang, Paul P.S., Li, Ka Leung, Casolari, Debora A., Feng, Jinghua, Pinese, Mark, Maung, Kyaw Ze Ya, Leo, Paul, Cowley, Mark, Perkins, Kelly, Smith, Amanda M., Ellis, Jonathan, Wee, Amilia, Hiwase, Devendra K., Scott, Hamish S., Schreiber, Andreas W., Brown, Anna L., Deans, Andrew J., Ross, David M., Moore, Andrew S., Gonda, Thomas J., Hahn, Christopher N., D'Andrea, Richard J.

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Signalling by the βc family of cytokines by Hercus, Timothy R, Dhagat, Urmi, Kan, Winnie L.T, Broughton, Sophie E, Nero, Tracy L, Perugini, Michelle, Sandow, Jarrod J, D’Andrea, Richard J, Ekert, Paul G, Hughes, Timothy, Parker, Michael W, Lopez, Angel F

“…Abstract The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the βc family due to their receptors sharing the signalling subunit βc, regulates…”
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Dynamic evolution of clonal epialleles revealed by methclone by Li, Sheng, Garrett-Bakelman, Francine, Perl, Alexander E, Luger, Selina M, Zhang, Chao, To, Bik L, Lewis, Ian D, Brown, Anna L, D'Andrea, Richard J, Ross, M Elizabeth, Levine, Ross, Carroll, Martin, Melnick, Ari, Mason, Christopher E

“…We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles)…”
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The double life of KLF5: Opposing roles in regulation of gene‐expression, cellular function, and transformation by Diakiw, Sonya M., D'Andrea, Richard J., Brown, Anna L.

“…The mechanisms by which cells control their growth and behavioral identities are complex and require adaptability to environmental changes. Transcription…”
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miR-155 as a potential target of IL-3 signaling in primary AML cells by Sadras, Teresa, Kok, Chung H, Perugini, Michelle, Ramshaw, Hayley S, D’Andrea, Richard J

“…Abstract miR-155 has emerged as one of the key microRNAs (miRNAs) involved in normal and malignant myelopoiesis, and high expression of this miRNA has been…”
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Genome-wide identification of human FOXP3 target genes in natural regulatory T cells by Sadlon, Timothy J, Wilkinson, Bridget G, Pederson, Stephen, Brown, Cheryl Y, Bresatz, Suzanne, Gargett, Tessa, Melville, Elizabeth L, Peng, Kaimen, D'Andrea, Richard J, Glonek, Gary G, Goodall, Gregory J, Zola, Heddy, Shannon, M Frances, Barry, Simon C

“…The transcription factor FOXP3 is essential for the formation and function of regulatory T cells (Tregs), and Tregs are essential for maintaining immune…”
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An optimized algorithm for detecting and annotating regional differential methylation by Li, Sheng, Garrett-Bakelman, Francine E, Akalin, Altuna, Zumbo, Paul, Levine, Ross, To, Bik L, Lewis, Ian D, Brown, Anna L, D'Andrea, Richard J, Melnick, Ari, Mason, Christopher E

“…DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome that are altered during development or that are perturbed by…”
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Self-reverting mutations partially correct the blood phenotype in a Diamond Blackfan anemia patient by Venugopal, Parvathy, Moore, Sarah, Lawrence, David M, George, Amee J, Hannan, Ross D, Bray, Sarah Ce, To, Luen Bik, D'Andrea, Richard J, Feng, Jinghua, Tirimacco, Amanda, Yeoman, Alexandra L, Young, Chun Chun, Fine, Miriam, Schreiber, Andreas W, Hahn, Christopher N, Barnett, Christopher, Saxon, Ben, Scott, Hamish S

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Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice by Dawar, Swati, Shahrin, Nur Hezrin, Sladojevic, Nikolina, D'Andrea, Richard J, Dorstyn, Loretta, Hiwase, Devendra K, Kumar, Sharad

“…The apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some…”
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