Search Results - "D'Ambrosio, Shannon"

Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders by Steinman, Michael Q., Kirson, Dean, Wolfe, Sarah A., Khom, Sophia, D’Ambrosio, Shannon R., Spierling Bagsic, Samantha R., Bajo, Michal, Vlkolinský, Roman, Hoang, Noah K., Singhal, Anshita, Sureshchandra, Suhas, Oleata, Christopher S., Messaoudi, Ilhem, Zorrilla, Eric P., Roberto, Marisa

“…Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share mechanisms that could be therapeutic targets. To facilitate mechanistic…”
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Impact and Role of Hypothalamic Corticotropin Releasing Hormone Neurons in Withdrawal from Chronic Alcohol Consumption in Female and Male Mice by Neira, Sofia, Lee, Sophia, Hassanein, Leslie A, Sides, Tori, D'Ambrosio, Shannon L, Boyt, Kristen M, Bains, Jaideep S, Kash, Thomas L

“…Worldwide, alcohol use and abuse are a leading risk of mortality, causing 5.3% of all deaths (World Health Organization, 2022). The endocrine stress system,…”
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IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake by Patel, Reesha R., Wolfe, Sarah A., Bajo, Michal, Abeynaike, Shawn, Pahng, Amanda, Borgonetti, Vittoria, D’Ambrosio, Shannon, Nikzad, Rana, Edwards, Scott, Paust, Silke, Roberts, Amanda J., Roberto, Marisa

“…Alcohol elicits a neuroimmune response in the brain contributing to the development and maintenance of alcohol use disorder (AUD). While pro-inflammatory…”
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Diagnostic delay in psychogenic seizures and the association with anti-seizure medication trials by Kerr, Wesley T., Ph.D, Janio, Emily A, Le, Justine M., B.S, Hori, Jessica M., B.S, Patel, Akash B, Gallardo, Norma L., B.A, Bauirjan, Janar, R.N., B.S.N, Chau, Andrea M., B.S, D’Ambrosio, Shannon R, Cho, Andrew Y., M.S, Engel, Jerome, M.D.-Ph.D, Cohen, Mark S., Ph.D, Stern, John M., M.D

“…Abstract Purpose The average delay from first seizure to diagnosis of psychogenic non-epileptic seizures (PNES) is over 7 years. The reason for this delay is…”
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Chronic alcohol consumption alters home‐cage behaviors and responses to ethologically relevant predator tasks in mice by Neira, Sofia, Hassanein, Leslie A., Stanhope, Christina M., Buccini, Michelle C., D'Ambrosio, Shannon L., Flanigan, Meghan E., Haun, Harold L., Boyt, Kristen M., Bains, Jaideep S., Kash, Thomas L.

“…Background Alcohol withdrawal is a key component of severe alcohol use disorder. Animal models of alcohol withdrawal tend to focus on traditional…”
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Insula Dynorphin and Kappa Opioid Receptor Systems Regulate Alcohol Drinking in a Sex-Specific Manner in Mice by Pina, Melanie M, Pati, Dipanwita, Neira, Sofia, Taxier, Lisa R, Stanhope, Christina M, Mahoney, Alexandra A, D'Ambrosio, Shannon, Kash, Thomas L, Navarro, Montserrat

“…Alcohol use disorder is complex and multifaceted, involving the coordination of multiple signaling systems across numerous brain regions. Previous work has…”
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The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder by Varodayan, Florence P., Patel, Reesha R., Matzeu, Alessandra, Wolfe, Sarah A., Curley, Dallece E., Khom, Sophia, Gandhi, Pauravi J., Rodriguez, Larry, Bajo, Michal, D’Ambrosio, Shannon, Sun, Hui, Kerr, Tony M., Gonzales, Rueben A., Leggio, Lorenzo, Natividad, Luis A., Haass-Koffler, Carolina L., Martin-Fardon, Rémi, Roberto, Marisa

“…Alcohol use disorder (AUD) is a leading preventable cause of death. The central amygdala (CeA) is a hub for stress and AUD, while dysfunction of the…”
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Alcohol Dependence Modifies Brain Networks Activated During Withdrawal and Reaccess: A c-Fos–Based Analysis in Mice by Roland, Alison V., Coelho, Cesar A.O., Haun, Harold L., Gianessi, Carol A., Lopez, Marcelo F., D’Ambrosio, Shannon, Machinski, Samantha N., Kroenke, Christopher D., Frankland, Paul W., Becker, Howard C., Kash, Thomas L.

“…High-level alcohol consumption causes neuroplastic changes in the brain that promote pathological drinking behavior. Some of these changes have been…”
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Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol by Patel, Reesha R., Wolfe, Sarah A., Borgonetti, Vittoria, Gandhi, Pauravi J., Rodriguez, Larry, Snyder, Angela E., D’Ambrosio, Shannon, Bajo, Michal, Domissy, Alain, Head, Steven, Contet, Candice, Dayne Mayfield, R., Roberts, Amanda J., Roberto, Marisa

“…Prefrontal circuits are thought to underlie aberrant emotion contributing to relapse in abstinence; however, the discrete cell-types and mechanisms remain…”
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Objective score from initial interview identifies patients with probable dissociative seizures by Kerr, Wesley T., Janio, Emily A., Chau, Andrea M., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Gallardo, Norma L., Allas, Corinne H., Karimi, Amir H., Dubey, Ishita, Sreenivasan, Siddhika S., Bauirjan, Janar, Hwang, Eric S., Davis, Emily C., D'Ambrosio, Shannon R., Al Banna, Mona, Mazumder, Rajarshi, Wu, Ting, DeCant, Zachary A., Gibbs, Michael G., Chang, Edward, Zhang, Xingruo, Cho, Andrew Y., Beimer, Nicholas J., Engel, Jerome, Cohen, Mark S., Stern, John M.

“…•20 of 76 factors contributed to the dissociative seizures likelihood score (DSLS).•DSLS correctly identified 77% of patients with ES or DS.•DSLS was…”
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Identifying psychogenic seizures through comorbidities and medication history by Kerr, Wesley T., Janio, Emily A., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Gallardo, Norma L., Bauirjan, Janar, D'Ambrosio, Shannon R., Chau, Andrea M., Hwang, Eric S., Davis, Emily C., Buchard, Albert, Torres‐Barba, David, Al Banna, Mona, Barritt, Sarah E., Cho, Andrew Y., Engel, Jerome, Cohen, Mark S., Stern, John M.

“…Summary Objective Low‐cost evidence‐based tools are needed to facilitate the early identification of patients with possible psychogenic nonepileptic seizures…”
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Factors associated with delay to video-EEG in dissociative seizures by Kerr, Wesley T., Zhang, Xingruo, Hill, Chloe E., Janio, Emily A., Chau, Andrea M., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Allas, Corinne H., Karimi, Amir H., Dubey, Ishita, Sreenivasan, Siddhika S., Gallardo, Norma L., Bauirjan, Janar, Hwang, Eric S., Davis, Emily C., D'Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Dewar, Sandra R., Engel, Jerome, Feusner, Jamie D., Stern, John M.

“…•The mean delay to VEM was 8.4 years (median 3 years).•Delay was associated with polytherapy and more ASM trials prior to VEM.•Increased medical complexity was…”
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Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice by Haun, Harold L., D'Ambrosio, Shannon L., Pati, Dipanwita, Taxier, Lisa R., Kash, Thomas L.

“…Binge drinking is a common pattern of excessive alcohol consumption associated with Alcohol Use Disorder (AUD) and unraveling the neurocircuitry that promotes…”
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IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder by Borgonetti, Vittoria, Cruz, Bryan, Vozella, Valentina, Khom, Sophia, Steinman, Michael Q, Bullard, Ryan, D'Ambrosio, Shannon, Oleata, Christopher S, Vlkolinsky, Roman, Bajo, Michal, Zorrilla, Eric P, Kirson, Dean, Roberto, Marisa

“…Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share dysregulated neuroimmune-related pathways. Here, we used our established rat…”
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Epilepsy, dissociative seizures, and mixed: Associations with time to video-EEG by Kerr, Wesley T., Zhang, Xingruo, Hill, Chloe E., Janio, Emily A., Chau, Andrea M., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Allas, Corinne H., Karimi, Amir H., Dubey, Ishita, Sreenivasan, Siddhika S., Gallardo, Norma L., Bauirjan, Janar, Hwang, Eric S., Davis, Emily C., D’Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Dewar, Sandra R., Engel, Jerome, Feusner, Jamie D., Stern, John M.

“…•There are delays to video-electroencephalographic monitoring for seizures.•Access to healthcare through employment or school shortens delays.•Ictal behavior…”
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Title: Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability by Kerr, Wesley T, Sreenivasan, Siddhika S, Allas, Corinne H, Janio, Emily A, Karimi, Amir H, Dubey, Ishita, D'Ambrosio, Shannon R, Smith, Jena M, Engel, Jr, Jerome, Feusner, Jamie D, Stern, John M

“…The clinical characteristics of functional seizures may vary based on age-of-onset or age-of-presentation. Description of age-related differences has focused…”
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Reliability of additional reported seizure manifestations to identify dissociative seizures by Kerr, Wesley T., Zhang, Xingruo, Janio, Emily A., Karimi, Amir H., Allas, Corinne H., Dubey, Ishita, Sreenivasan, Siddhika S., Bauirjan, Janar, D'Ambrosio, Shannon R., Al Banna, Mona, Cho, Andrew Y., Engel Jr, Jerome, Cohen, Mark S., Feusner, Jamie D., Stern, John M.

“…•Pre-ictal headache was more specific for dissociative seizures (DS) than post-ictal headache.•Ictal sensory symptoms and seizures triggered by emotional…”
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An objective score to identify psychogenic seizures based on age of onset and history by Kerr, Wesley T., Janio, Emily A., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Gallardo, Norma L., Bauirjan, Janar, Chau, Andrea M., Hwang, Eric S., Davis, Emily C., Buchard, Albert, Torres-Barba, David, D'Ambrosio, Shannon, Al Banna, Mona, Cho, Andrew Y., Engel, Jerome, Cohen, Mark S., Stern, John M.

“…Psychogenic nonepileptic seizure (PNES) is a common diagnosis after evaluation of medication resistant or atypical seizures with video-electroencephalographic…”
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Corrigendum to ‘Functional seizures across the adult lifespan: female sex, delay to diagnosis and disability’ [Seizure: European Journal of Epilepsy (2021) 476-483] by Kerr, Wesley T., Sreenivasan, Siddhika S., Allas, Corinne H., Janio, Emily A., Karimi, Amir H., Dubey, Ishita, D'Ambrosio, Shannon R., Smith, Jena M., Engel Jr, Jerome, Feusner, Jamie D., Stern, John M.

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Reliability of reported peri-ictal behavior to identify psychogenic nonepileptic seizures by Kerr, Wesley T., Chau, Andrea M., Janio, Emily A., Braesch, Chelsea T., Le, Justine M., Hori, Jessica M., Patel, Akash B., Gallardo, Norma L., Bauirjan, Janar, Allas, Corinne H., Karimi, Amir H., Hwang, Eric S., Davis, Emily C., Buchard, Albert, Torres-Barba, David, D'Ambrosio, Shannon, Al Banna, Mona, Cho, Andrew Y., Engel, Jerome, Cohen, Mark S., Stern, John M.

“…•Differentiating PNES from ES from reported history is challenging.•Patient and witness reported peri-ictal behavior were moderately helpful (AUC 75%).•Median…”
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