Search Results - "D'Ambrosio, Elizabeth A."

Synthesis of Functionalized N‑Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis by DeMeester, Kristen E, Liang, Hai, Jensen, Matthew R, Jones, Zachary S, D’Ambrosio, Elizabeth A, Scinto, Samuel L, Zhou, Junhui, Grimes, Catherine L

“…Uridine diphosphate N-acetyl muramic acid (UDP NAM) is a critical intermediate in bacterial peptidoglycan (PG) biosynthesis. As the primary source of muramic…”
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Differential Peptidoglycan Recognition Assay Using Varied Surface Presentations by D’Ambrosio, Elizabeth A, Bersch, Klare L, Lauro, Mackenzie L, Grimes, Catherine L

“…Bacterial peptidoglycan (PG) is recognized by the human innate immune system to generate an appropriate response. To gain an appreciation of how this essential…”
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Customized peptidoglycan surfaces to investigate innate immune recognition via surface plasmon resonance by Le, Ha T, D'Ambrosio, Elizabeth A, Mashayekh, Siavash, Grimes, Catherine Leimkuhler

“…Glycan-protein interactions facilitate some of the most important biomolecular processes in and between cells. They are involved in different cellular…”
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Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools by Scherzi, Tyler, D'Ambrosio, Elizabeth A., Daher, Samer S., Grimes, Catherine L., Dunman, Paul M., Andrade, Rodrigo B.

“…[Display omitted] Small molecule target identification is a critical step in modern antibacterial drug discovery, particularly against multi-drug resistant…”
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Synthesis and Application of Methyl N,O‐Hydroxylamine Muramyl Peptides by Lazor, Klare M., Zhou, Junhui, DeMeester, Kristen E., D'Ambrosio, Elizabeth A., Grimes, Catherine L.

“…The innate immune system's interaction with bacterial cells plays a pivotal role in a variety of human diseases. Carbohydrate units derived from a component of…”
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Modulation of the NOD-like receptors NOD1 and NOD2: A chemist’s perspective by D'Ambrosio, Elizabeth A., Drake, Walter R., Mashayekh, Siavash, Ukaegbu, Ophelia I., Brown, Ashley R., Grimes, Catherine L.

“…[Display omitted] The innate immune system is the body’s first defense against invading microorganisms, relying on the recognition of bacterial-derived small…”
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Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2 by Lauro, Mackenzie L, D’Ambrosio, Elizabeth A, Bahnson, Brian J, Grimes, Catherine Leimkuhler

“…Genetic mutations in the innate immune receptor nucleotide-binding oligomerization domain-containing 2 (Nod2) have demonstrated increased susceptibility to…”
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Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus by Liang, Hai, Zhou, Guangfeng, Ge, Yunhui, D'Ambrosio, Elizabeth A., Eidem, Tess M., Blanchard, Catlyn, Shehatou, Cindy, Chatare, Vijay K., Dunman, Paul M., Valentine, Ann M., Voelz, Vincent A., Grimes, Catherine L., Andrade, Rodrigo B.

“…[Display omitted] Antibiotic resistance is a serious threat to global public health, and methicillin-resistant Staphylococcus aureus (MRSA) is a poignant…”
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Probing the Peptidoglycan Molecular Recognition Mechanisms of Innate Immune Receptors NOD2 and NLRP1 Leucine Rich Repeat Domains by D'Ambrosio, Elizabeth A

“…The innate immune system is the body’s first line of defense against invading microbial pathogens. A critical component of this immune defense are the…”
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