Search Results - "D'Amato, Robert"

Angiogenesis in Wounds Treated by Microdeformational Wound Therapy by ERBA, Paolo, OGAWA, Rei, KONERDING, Moritz A, ORGILL, Dennis P, ACKERMANN, Maximilian, ADINI, Avner, MIELE, Lino F, DASTOURI, Pouya, HELM, Doug, MENTZER, Steven J, D'AMATO, Robert J, MURPHY, George F

“…Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum…”
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Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes by Bai, Jing, Khajavi, Mehrdad, Sui, Lufei, Fu, Haojie, Tarakkad Krishnaji, Subrahmanian, Birsner, Amy E., Bazinet, Lauren, Kamm, Roger D., D’Amato, Robert J.

“…Angiogenesis plays a key role in the pathology of diseases such as cancer, diabetic retinopathy, and age-related macular degeneration. Understanding the…”
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Anti-angiogenic properties of microRNA-29a in preclinical ocular models by Peng, De-Wei, Lan, Chun-Lin, Dong, Ling-Qin, Jiang, Meng-Xi, Xiao, Huan, D’Amato, Robert J., Chi, Zai-Long

“…Abnormal neovascularization is an important cause of blindness in many ocular diseases, for which the etiology and pathogenic mechanisms remain incompletely…”
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Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma by Fu, Haojie, Siggs, Owen M, Knight, Lachlan Sw, Staffieri, Sandra E, Ruddle, Jonathan B, Birsner, Amy E, Collantes, Edward Ryan, Craig, Jamie E, Wiggs, Janey L, D'Amato, Robert J

“…Glaucoma is a highly heritable disease that is a leading cause of blindness worldwide. Here, we identified heterozygous thrombospondin 1 (THBS1) missense…”
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Forty-year journey of angiogenesis translational research by Cao, Yihai, Arbiser, Jack, D'Amato, Robert J, D'Amore, Patricia A, Ingber, Donald E, Kerbel, Robert, Klagsbrun, Michael, Lim, Sharon, Moses, Marsha A, Zetter, Bruce, Dvorak, Harold, Langer, Robert

“…Forty years ago, Judah Folkman predicted that tumor growth is dependent on angiogenesis and that inhibiting this process might be a new strategy for cancer…”
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The Prominin-1-Derived Peptide Improves Cardiac Function Following Ischemia by Adini, Avner, Adini, Irit, Grad, Etty, Tal, Yuval, Danenberg, Haim D, Kang, Peter M, Matthews, Benjamin D, D'Amato, Robert J

“…Myocardial infarction (MI) remains the leading cause of death in the western world. Despite advancements in interventional revascularization technologies, many…”
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Identification of Basp1 as a novel angiogenesis‐regulating gene by multi‐model system studies by Khajavi, Mehrdad, Zhou, Yi, Schiffer, Alex J., Bazinet, Lauren, Birsner, Amy E., Zon, Leonard, D’Amato, Robert J.

“…We have previously used the genetic diversity available in common inbred mouse strains to identify quantitative trait loci (QTLs) responsible for the…”
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Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo by Xu, Hui, M.D., Ph.D, Becker, Christian M., M.D, Lui, Wai Ting, M.Phil, Chu, Ching Yan, M.Phil, Davis, Tina N, Kung, Andrew L., M.D., Ph.D, Birsner, Amy E., Ph.D, D’Amato, Robert J., M.D., Ph.D, Wai Man, Gene Chi, M.Phil, Wang, Chi Chiu, M.D., Ph.D

“…Objective To investigate the antiangiogenesis mechanism of epigallocatechin-3-gallate (EGCG) in an endometriosis model in vivo. Design Animal studies. Setting…”
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Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes by Wu, Hao, Rahman, H N Ashiqur, Dong, Yunzhou, Liu, Xiaolei, Lee, Yang, Wen, Aiyun, To, Kim Ht, Xiao, Li, Birsner, Amy E, Bazinet, Lauren, Wong, Scott, Song, Kai, Brophy, Megan L, Mahamud, M Riaj, Chang, Baojun, Cai, Xiaofeng, Pasula, Satish, Kwak, Sukyoung, Yang, Wenxia, Bischoff, Joyce, Xu, Jian, Bielenberg, Diane R, Dixon, J Brandon, D'Amato, Robert J, Srinivasan, R Sathish, Chen, Hong

“…Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this…”
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Low dose amiodarone reduces tumor growth and angiogenesis by Steinberg, Eliana, Fluksman, Arnon, Zemmour, Chalom, Tischenko, Katerina, Karsch-Bluman, Adi, Brill-Karniely, Yifat, Birsner, Amy E., D’Amato, Robert J., Benny, Ofra

“…Amiodarone is an anti-arrhythmic drug that was approved by the US Food and Drug Administration (FDA) in 1985. Pre-clinical studies suggest that Amiodarone…”
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MicroRNA-18a-5p Administration Suppresses Retinal Neovascularization by Targeting FGF1 and HIF1A by Guan, Ji-Tian, Li, Xin-Xin, Peng, De-Wei, Zhang, Wen-Meng, Qu, Jia, Lu, Fan, D'Amato, Robert J, Chi, Zai-Long

“…Pathologic ocular neovascularization commonly results in visual impairment or even blindness in numerous fundus diseases, including proliferative diabetic…”
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VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients by Peterson, Jon E., Zurakowski, David, Italiano, Joseph E., Michel, Lea V., Connors, Susan, Oenick, Marsha, D’Amato, Robert J., Klement, Giannoula L., Folkman, Judah

“…Platelets sequester angiogenesis regulatory proteins which suggests an avenue for developing biomarkers to monitor disease. We describe a comparison of…”
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A novel strategy to enhance angiogenesis in vivo using the small VEGF-binding peptide PR1P by Adini, Avner, Adini, Irit, Chi, Zai-long, Derda, Ratmir, Birsner, Amy E., Matthews, Benjamin D., D’Amato, Robert J.

“…Therapeutic angiogenesis is an experimental frontier in vascular biology that seeks to deliver angiogenic growth factors to ischemic or injured tissues to…”
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Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment by Adini, Irit, Ghosh, Kaustabh, Adini, Avner, Chi, Zai-Long, Yoshimura, Takeru, Benny, Ofra, Connor, Kip M, Rogers, Michael S, Bazinet, Lauren, Birsner, Amy E, Bielenberg, Diane R, D'Amato, Robert J

“…Studies have established that pigmentation can provide strong, protective effects against certain human diseases. For example, angiogenesis-dependent diseases…”
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2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor-1α and Suppresses Growth of Lesions in a Mouse Model of Endometriosis by Becker, Christian M, Rohwer, Nadine, Funakoshi, Tae, Cramer, Thorsten, Bernhardt, Wanja, Birsner, Amy, Folkman, Judah, D'Amato, Robert J

“…Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years…”
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An orally delivered small-molecule formulation with antiangiogenic and anticancer activity by Adini, Avner, Nahmias, Yaakov, Koirala, Samir, Benny, Ofra, Pravda, Elke, Cassiola, Flavia, Corfas, Gabriel, Fainaru, Ofer, Bazinet, Lauren, Adini, Irit, Folkman, Judah, D'Amato, Robert J

“…Widespread use of antiangiogenic drugs for cancer therapy is limited in part by the requirement for intravenous injection. Benny et al . describe an oral…”
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Characterization of a spontaneous retinal neovascular mouse model by Hasegawa, Eiichi, Sweigard, Harry, Husain, Deeba, Olivares, Ana M, Chang, Bo, Smith, Kaylee E, Birsner, Amy E, D'Amato, Robert J, Michaud, Norman A, Han, Yinan, Vavvas, Demetrios G, Miller, Joan W, Haider, Neena B, Connor, Kip M

“…Vision loss due to vascular disease of the retina is a leading cause of blindness in the world. Retinal angiomatous proliferation (RAP) is a subgroup of…”
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Melanocyte pigmentation inversely correlates with MCP‐1 production and angiogenesis‐inducing potential by Adini, Irit, Adini, Avner, Bazinet, Lauren, Watnick, Randolph S., Bielenberg, Diane R., D'Amato, Robert J.

“…ABSTRACT The incidence of certain angiogenesis‐dependent diseases is higher in Caucasians than in African Americans. Angiogenesis is amplified in wound healing…”
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Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice by Khajavi, Mehrdad, Zhou, Yi, Birsner, Amy E, Bazinet, Lauren, Rosa Di Sant, Amanda, Schiffer, Alex J, Rogers, Michael S, Krishnaji, Subrahmanian Tarakkad, Hu, Bella, Nguyen, Vy, Zon, Leonard, D'Amato, Robert J

“…Recent findings indicate that growth factor-driven angiogenesis is markedly influenced by genetic variation. This variation in angiogenic responsiveness may…”
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A Method for Developing Novel 3D Cornea-on-a-Chip Using Primary Murine Corneal Epithelial and Endothelial Cells by Bai, Jing, Fu, Haojie, Bazinet, Lauren, Birsner, Amy E, D'Amato, Robert J

“…Microfluidic-based organ-on-a-chip assays with simultaneous coculture of multi-cell types have been widely utilized for basic research and drug development…”
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