Search Results - "D'Alto, M."

Often transferred, rarely transitioned: The current state of transition for young people with congenital heart disease by Dimopoulos, K., Opotowsky, A.R., Constantine, A., D'Alto, M.

Get full text

Past and current cause-specific mortality in Eisenmenger syndrome by Hjortshøj, Cristel M Sørensen, Kempny, Aleksander, Jensen, Annette Schophuus, Sørensen, Keld, Nagy, Edit, Dellborg, Mikael, Johansson, Bengt, Rudiene, Virginija, Hong, Gu, Opotowsky, Alexander R, Budts, Werner, Mulder, Barbara J, Tomkiewicz-Pajak, Lidia, D'Alto, Michele, Prokšelj, Katja, Diller, Gerhard-Paul, Dimopoulos, Konstantinos, Estensen, Mette-Elise, Holmstrøm, Henrik, Turanlahti, Maila, Thilén, Ulf, Gatzoulis, Michael A, Søndergaard, Lars

“…Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction with an…”
Get full text

Exercise stress echocardiography for the study of the pulmonary circulation by ARGIENTO, P, CHESTER, N, MULE, M, D'ALTO, M, BOSSONE, E, UNGER, P, NAEIJE, R

“…Exercise stress tests have been used for the diagnosis of pulmonary hypertension, but with variable protocols and uncertain limits of normal. The pulmonary…”
Get full text

Long term effects of bosentan treatment in adult patients with pulmonary arterial hypertension related to congenital heart disease (Eisenmenger physiology): safety, tolerability, clinical, and haemodynamic effect by D’Alto, M, Vizza, C D, Romeo, E, Badagliacca, R, Santoro, G, Poscia, R, Sarubbi, B, Mancone, M, Argiento, P, Ferrante, F, Russo, M G, Fedele, F, Calabrò, R

“…Background: Oral bosentan is an established treatment for pulmonary arterial hypertension (PAH). Objective: To evaluate safety, tolerability, and clinical and…”
Get full text

Bacteria Fighting Back: How Pathogens Target and Subvert the Host Innate Immune System by Reddick, L. Evan, Alto, Neal M.

“…The innate immune system has evolved under selective pressure since the radiation of multicellular life approximately 600 million years ago. Because of this…”
Get full text

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease by Dobbs, Nicole, Burnaevskiy, Nikolay, Chen, Didi, Gonugunta, Vijay K., Alto, Neal M., Yan, Nan

“…STING is an ER-associated membrane protein that is critical for innate immune sensing of pathogens. STING-mediated activation of the IFN-I pathway through the…”
Get full text

PP-372 Characteristics of Adults with Congenital Heart Disease and Pulmonary Arterial Hypertension in the COMPERA-CHD Registry by Kaemmerer, H, Pittrow, D, Huscher, D, Tiede, H, Delcroix, M, Gorenflo, M, D'alto, M, Pujol, C, Praus, A, Engelhardt, A, Ewert, P, Hoeper, M.M

“…Conclusion Current COMPERA data indicate that CHD patients * relative to the severity of the disease, are young and have a high exercise capacity, but…”
Get full text

Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8 by Yin, Hang, Zheng, Jian, He, Qiuqiu, Zhang, Xuan, Li, Xuzichao, Ma, Yongjian, Liang, Xiao, Gao, Jiaqi, Kocsis, Benjamin L., Li, Zhuang, Liu, Xiang, Alto, Neal M., Li, Long, Zhang, Heng

“…The multifunctional GSDMB protein is an important molecule in human immunity. The pyroptotic and bactericidal activity of GSDMB is a host response to infection…”
Get full text

Myristoylome Profiling Reveals a Concerted Mechanism of ARF GTPase Deacylation by the Bacterial Protease IpaJ by Burnaevskiy, Nikolay, Peng, Tao, Reddick, L. Evan, Hang, Howard C., Alto, Neal M.

“…N-myristoylation is an essential fatty acid modification that governs the localization and activity of cell signaling enzymes, architectural proteins, and…”
Get full text

Subversion of cell signaling by pathogens by Alto, Neal M, Orth, Kim

“…Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for…”
Get full text

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein by Zhang, Ruihui, Lee, Donghoon M., Jimah, John R., Gerassimov, Nathalie, Yang, Changsong, Kim, Sangjoon, Luvsanjav, Delgermaa, Winkelman, Jonathan, Mettlen, Marcel, Abrams, Michael E., Kalia, Raghav, Keene, Peter, Pandey, Pratima, Ravaux, Benjamin, Kim, Ji Hoon, Ditlev, Jonathon A., Zhang, Guofeng, Rosen, Michael K., Frost, Adam, Alto, Neal M., Gardel, Margaret, Schmid, Sandra L., Svitkina, Tatyana M., Hinshaw, Jenny E., Chen, Elizabeth H.

“…The dynamin GTPase is known to bundle actin filaments, but the underlying molecular mechanism and physiological relevance remain unclear. Our genetic analyses…”
Get full text

Efficacy of pharmacological treatment and genetic characterization in early diagnosed patients affected by long QT syndrome with impaired AV conduction by Sarubbi, B, Frisso, G, Romeo, E, Evangelista, E, Cordella, A, D'Alto, M, Santarpia, G, Russo, M.G, Salvatore, F, Calabrò, R

Get full text

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes by Weigele, Bethany A., Orchard, Robert C., Jimenez, Alyssa, Cox, Gregory W., Alto, Neal M.

“…Membrane-bound organelles serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells…”
Get full text

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ by Burnaevskiy, Nikolay, Fox, Thomas G., Plymire, Daniel A., Ertelt, James M., Weigele, Bethany A., Selyunin, Andrey S., Way, Sing Sing, Patrie, Steven M., Alto, Neal M.

“…An irreversible mechanism of protein demyristoylation catalysed by invasion plasmid antigen J (IpaJ), a Shigella flexneri type III effector protein with…”
Get full text

Accessible cholesterol is localized in bacterial plasma membrane protrusions by Abrams, Michael E., Johnson, Kristen A., Radhakrishnan, Arun, Alto, Neal M.

Get full text

Toxins, mutations and adaptations by De Jong, Maarten, Alto, Neal M

“…The toxins that some bacteria secrete to kill off rival species can also generate mutations that help toxin-resistant populations adapt to new environments…”
Get full text

Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery by Embry, Aaron, Baggett, Nina S, Heisler, David B, White, Addison, de Jong, Maarten F, Kocsis, Benjamin L, Tomchick, Diana R, Alto, Neal M, Gammon, Don B

“…Arboviruses are a diverse group of insect-transmitted pathogens that pose global public health challenges. Identifying evolutionarily conserved host factors…”
Get full text

ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis by Ramirez, Nora-Guadalupe P., Lee, Jeon, Zheng, Yue, Li, Lianbo, Dennis, Bryce, Chen, Didi, Challa, Ashwini, Planelles, Vicente, Westover, Kenneth D., Alto, Neal M., D’Orso, Iván

“…Immune stimulation fuels cell signaling-transcriptional programs inducing biological responses to eliminate virus-infected cells. Yet, retroviruses that…”
Get full text

Rab32 Modulates Apoptosis Onset and Mitochondria-associated Membrane (MAM) Properties by Bui, Michael, Gilady, Susanna Y., Fitzsimmons, Ross E.B., Benson, Matthew D., Lynes, Emily M., Gesson, Kevin, Alto, Neal M., Strack, Stefan, Scott, John D., Simmen, Thomas

“…The mitochondria-associated membrane (MAM) has emerged as an endoplasmic reticulum (ER) signaling hub that accommodates ER chaperones, including the lectin…”
Get full text

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection by Heisler, David B, Johnson, Kristen A, Ma, Duo H, Ohlson, Maikke B, Zhang, Lishu, Tran, Michelle, Corley, Chase D, Abrams, Michael E, McDonald, Jeffrey G, Schoggins, John W, Alto, Neal M, Radhakrishnan, Arun

“…Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through interactions with phospholipids and transmembrane domains of…”
Get full text