Search Results - "D'Alincourt Salazar, Marcela"
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Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice
Published in PloS one (06-09-2019)“…The five-year survival rate of patients diagnosed with advanced pancreatic ductal adenocarcinoma (PDAC) has remained static at <5% despite decades of research…”
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Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism
Published in BMC cancer (07-04-2020)“…Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues…”
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Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells
Published in Biochemical and biophysical research communications (13-02-2015)“…Estrogen (E2) supports breast cancer cell growth but suppresses invasiveness and both actions are antagonized by anti-estrogens. As a consequence,…”
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Intranasal Administration of Perillyl Alcohol Activates Peripheral and Bronchus-Associated Immune System In Vivo
Published in Archivum Immunologiae et Therapiae Experimentalis (01-02-2014)“…Perillyl alcohol (POH) presents antitumoral activity but clinical application is hampered by adverse effects following oral administration. This work aimed to…”
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Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
Published in Nature communications (30-11-2020)“…Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer. We…”
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Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer
Published in Molecular therapy. Oncolytics (16-12-2020)“…Baicalein is a Chinese herbal compound extracted from Scutellaria baicalensis that has anti-tumor properties. The aim of this study was to elucidate the…”
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Hormone Depletion-Insensitivity of Prostate Cancer Cells Is Supported by the AR Without Binding to Classical Response Elements
Published in Molecular endocrinology (Baltimore, Md.) (01-04-2011)“…In hormone depletion-insensitive prostate cancer, the androgen receptor supports hormone-depletion insensitive growth by non-classical mechanisms of action on…”
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Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer
Published in Oncoimmunology (02-06-2016)“…Despite the clinical success of anti-PD1 antibody (α-PD1) therapy, the immune mechanisms contributing to the antineoplastic response remain unclear. Here, we…”
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Regulation of Folate Receptor Internalization by Protein Kinase C α
Published in Biochemistry (Easton) (01-09-2009)“…The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors,…”
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The folate receptor: what does it promise in tissue-targeted therapeutics?
Published in Cancer and metastasis reviews (01-03-2007)“…For over a decade the folate receptor has been intensively investigated as a means for tumor-specific delivery of a broad range of experimental therapies…”
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Patient with Recurrent Glioblastoma Responding Favorably to Ketogenic Diet Combined with Intranasal Delivery of Perillyl Alcohol: A Case Report and Literature Review
Published in Arquivos brasileiros de neurocirurgia (01-09-2017)“…Abstract Introduction Monoterpene perillyl alcohol (POH) is cytotoxic to temozolomide-resistant glioma cells, regardless of its…”
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Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer
Published in International journal of biological sciences (01-01-2021)“…Leflunomide (Lef) is an agent used in autoimmune disorders that interferes with DNA synthesis. pyrimidine synthesis is a mechanism of Gemcitabine (Gem)…”
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Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals
Published in Archivum Immunologiae et Therapiae Experimentalis (01-08-2017)“…Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER)…”
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Perillyl alcohol: Dynamic interactions with the lipid bilayer and implications for long-term inhalational chemotherapy for gliomas
Published in Surgical neurology international (01-01-2016)“…Background: Gliomas display a high degree of intratumor heterogeneity, including changes in physiological parameters and lipid composition of the plasma…”
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Abstract 2111: Role of gene repression by estrogen in invasiveness of breast cancer cells
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…More than 75% of breast tumors are estrogen receptor (ER)-positive and require estrogen for their growth and survival. Long-term adjuvant therapies that…”
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Efficacy of a ketogenic diet with concomitant intranasal perillyl alcohol as a novel strategy for the therapy of recurrent glioblastoma
Published in Oncology letters (01-01-2018)“…It has been hypothesized that persistent ketotic hypoglycemia represents a potential therapeutic strategy against high-grade gliomas. Perillyl alcohol (POH) is…”
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The folate receptor : What does it promise in tissue-targeted therapeutics? : Transporters in Cancer
Published in Cancer and metastasis reviews (2007)Get full text
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18
Regulation of Folate Receptor Internalization by Protein Kinase C a
Published in Biochemistry (Easton) (01-09-2009)“…The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors,…”
Get full text
Journal Article