Search Results - "D'Alincourt Salazar, Marcela"

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  1. 1

    Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice by Johnson, Benjamin L, d'Alincourt Salazar, Marcela, Mackenzie-Dyck, Sarah, D'Apuzzo, Massimo, Shih, Hung Ping, Manuel, Edwin R, Diamond, Don J

    Published in PloS one (06-09-2019)
    “…The five-year survival rate of patients diagnosed with advanced pancreatic ductal adenocarcinoma (PDAC) has remained static at <5% despite decades of research…”
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    Journal Article
  2. 2

    Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism by Faria, Giselle M, Soares, Igor D P, D'Alincourt Salazar, Marcela, Amorim, Marcia R, Pessoa, Bruno L, da Fonseca, Clovis O, Quirico-Santos, Thereza

    Published in BMC cancer (07-04-2020)
    “…Polymorphisms in MTHFR gene influence risk and overall survival of patients with brain tumor. Global genomic DNA (gDNA) methylation profile from tumor tissues…”
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    Journal Article
  3. 3

    Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells by Patki, Mugdha, Salazar, Marcela d'alincourt, Trumbly, Robert, Ratnam, Manohar

    “…Estrogen (E2) supports breast cancer cell growth but suppresses invasiveness and both actions are antagonized by anti-estrogens. As a consequence,…”
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  4. 4

    Intranasal Administration of Perillyl Alcohol Activates Peripheral and Bronchus-Associated Immune System In Vivo by D’Alincourt Salazar, Marcela, da Silva, Rafael Ferreira, Da Fonseca, Clovis Orlando, Lagrota-Candido, Jussara, Quirico-Santos, Thereza

    “…Perillyl alcohol (POH) presents antitumoral activity but clinical application is hampered by adverse effects following oral administration. This work aimed to…”
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    Inhibition of Autophagy Amplifies Baicalein-Induced Apoptosis in Human Colorectal Cancer by Phan, Thuy, Nguyen, Vu H., A’lincourt Salazar, Marcela, Wong, Paul, Diamond, Don J., Yim, John H., Melstrom, Laleh G.

    Published in Molecular therapy. Oncolytics (16-12-2020)
    “…Baicalein is a Chinese herbal compound extracted from Scutellaria baicalensis that has anti-tumor properties. The aim of this study was to elucidate the…”
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  7. 7

    Hormone Depletion-Insensitivity of Prostate Cancer Cells Is Supported by the AR Without Binding to Classical Response Elements by Gonit, Mesfin, Zhang, Juan, Salazar, Marcela d'Alincourt, Cui, Hongjuan, Shatnawi, Aymen, Trumbly, Robert, Ratnam, Manohar

    Published in Molecular endocrinology (Baltimore, Md.) (01-04-2011)
    “…In hormone depletion-insensitive prostate cancer, the androgen receptor supports hormone-depletion insensitive growth by non-classical mechanisms of action on…”
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  8. 8

    Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer by D'Alincourt Salazar, Marcela, Manuel, Edwin R., Tsai, Weimin, D'Apuzzo, Massimo, Goldstein, Leanne, Blazar, Bruce R., Diamond, Don J.

    Published in Oncoimmunology (02-06-2016)
    “…Despite the clinical success of anti-PD1 antibody (α-PD1) therapy, the immune mechanisms contributing to the antineoplastic response remain unclear. Here, we…”
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  9. 9

    Regulation of Folate Receptor Internalization by Protein Kinase C α by Elnakat, Hala, Gonit, Mesfin, D’Alincourt Salazar, Marcela, Zhang, Juan, Basrur, Venkatesha, Gunning, William, Kamen, Barton, Ratnam, Manohar

    Published in Biochemistry (Easton) (01-09-2009)
    “…The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors,…”
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    Journal Article
  10. 10

    The folate receptor: what does it promise in tissue-targeted therapeutics? by Salazar, Marcela D'Alincourt, Ratnam, Manohar

    Published in Cancer and metastasis reviews (01-03-2007)
    “…For over a decade the folate receptor has been intensively investigated as a means for tumor-specific delivery of a broad range of experimental therapies…”
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    Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals by Gomes, Aline C., Mello, Angélica L., Ribeiro, Manuel G., Garcia, Diogo G., Da Fonseca, Clovis O., Salazar, Marcela D’Alincourt, Schönthal, Axel H., Quirico-Santos, Thereza

    “…Monoterpenes such as limonene and perillyl alcohol (POH) are promising natural compounds with pro-oxidant properties partly due to endoplasmic reticulum (ER)…”
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  14. 14

    Perillyl alcohol: Dynamic interactions with the lipid bilayer and implications for long-term inhalational chemotherapy for gliomas by da Fonseca, Clovis, Khandelia, Himanshu, Salazar, Marcela, Schönthal, Axel, Meireles, Osório, Quirico-Santos, Thereza

    Published in Surgical neurology international (01-01-2016)
    “…Background: Gliomas display a high degree of intratumor heterogeneity, including changes in physiological parameters and lipid composition of the plasma…”
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  15. 15

    Abstract 2111: Role of gene repression by estrogen in invasiveness of breast cancer cells by Patki, Mugdha, Salazar, Marcela d'Alincourt, Trumbly, Robert, Ratnam, Manohar

    Published in Cancer research (Chicago, Ill.) (01-10-2014)
    “…More than 75% of breast tumors are estrogen receptor (ER)-positive and require estrogen for their growth and survival. Long-term adjuvant therapies that…”
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    Regulation of Folate Receptor Internalization by Protein Kinase C a by Elnakat, Hala, Gonit, Mesfin, Salazar, Marcela D'Alincourt, Zhang#, Juan, Basrur, Venkatesha, Gunning, William, Kamen, Barton, Ratnam, Manohar

    Published in Biochemistry (Easton) (01-09-2009)
    “…The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors,…”
    Get full text
    Journal Article