Search Results - "D'Alfonso, M"

Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy by Ginter, Paula S., Idress, Romana, D'Alfonso, Timothy M., Fineberg, Susan, Jaffer, Shabnam, Sattar, Abida K., Chagpar, Anees, Wilson, Parker, Harigopal, Malini

“…Breast carcinoma grading is an important prognostic feature recently incorporated into the AJCC Cancer Staging Manual. There is increased interest in applying…”
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Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism by Karagiannis, George S, Pastoriza, Jessica M, Wang, Yarong, Harney, Allison S, Entenberg, David, Pignatelli, Jeanine, Sharma, Ved P, Xue, Emily A, Cheng, Esther, D'Alfonso, Timothy M, Jones, Joan G, Anampa, Jesus, Rohan, Thomas E, Sparano, Joseph A, Condeelis, John S, Oktay, Maja H

“…Breast cancer cells disseminate through TIE2/MENA /MENA -dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which…”
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The Role of Novel Immunohistochemical Markers for Special Types of Breast Carcinoma by Grabenstetter, Anne, D’Alfonso, Timothy M.

“…Some histologic special types of breast carcinoma harbor specific recurrent genetic alterations that are not seen in other types of breast carcinoma (no…”
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The Effect of Age on Outcomes After Neoadjuvant Chemotherapy for Breast Cancer by Verdial, Francys C., Mamtani, Anita, Pawloski, Kate R., Sevilimedu, Varadan, D’Alfonso, Timothy M., Zhang, Hong, Gemignani, Mary L., Barrio, Andrea V., Morrow, Monica, Tadros, Audree B.

“…Background Younger women (age ≤ 40 years) with breast cancer undergoing neoadjuvant chemotherapy (NAC) have higher rates of pathologic complete response (pCR);…”
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Deep Multi-Magnification Networks for multi-class breast cancer image segmentation by Ho, David Joon, Yarlagadda, Dig V.K., D’Alfonso, Timothy M., Hanna, Matthew G., Grabenstetter, Anne, Ntiamoah, Peter, Brogi, Edi, Tan, Lee K., Fuchs, Thomas J.

“…•Multi-Magnification Network segments multiple tissue subtypes on pathology images.•Features from both high magnifications and low magnifications are fully…”
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Multi-magnification-based machine learning as an ancillary tool for the pathologic assessment of shaved margins for breast carcinoma lumpectomy specimens by D'Alfonso, Timothy M., Ho, David Joon, Hanna, Matthew G., Grabenstetter, Anne, Yarlagadda, Dig Vijay Kumar, Geneslaw, Luke, Ntiamoah, Peter, Fuchs, Thomas J., Tan, Lee K.

“…The surgical margin status of breast lumpectomy specimens for invasive carcinoma and ductal carcinoma in situ (DCIS) guides clinical decisions, as positive…”
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Androgen receptor splice variant-7 in breast cancer: clinical and pathologic correlations by Ferguson, Donna C., Mata, Douglas A., Tay, Timothy KY, Traina, Tiffany A., Gucalp, Ayca, Chandarlapaty, Sarat, D’Alfonso, Timothy M., Brogi, Edi, Mullaney, Kerry, Ladanyi, Marc, Arcila, Maria E., Benayed, Ryma, Ross, Dara S.

“…Androgen receptor (AR) inhibitor therapy is a developing treatment for AR-positive breast cancer (BC) with ongoing clinical trials. AR splice variant-7 (AR-V7)…”
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Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer by Rohan, Thomas E, Xue, Xiaonan, Lin, Hung-Mo, D'Alfonso, Timothy M, Ginter, Paula S, Oktay, Maja H, Robinson, Brian D, Ginsberg, Mindy, Gertler, Frank B, Glass, Andrew G, Sparano, Joseph A, Condeelis, John S, Jones, Joan G

“…Tumor microenvironment of metastasis (TMEM), consisting of direct contact between a macrophage, an endothelial cell, and a tumor cell, has been associated with…”
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Semi-automated analysis of HER2 immunohistochemistry in invasive breast carcinoma using whole slide images: utility for interpretation in clinical practice by Liao, Chiu-Hsiang Connie, Bakoglu, Nilay, Cesmecioglu, Emine, Hanna, Matthew, Pareja, Fresia, Wen, Hannah Y, D'Alfonso, Timothy M, Brogi, Edi, Yagi, Yukako, Ross, Dara S

“…( ) gene amplification and subsequent protein overexpression is a strong prognostic and predictive biomarker in invasive breast carcinoma (IBC). ASCO/CAP…”
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Mechanobiology of tumor invasion: Engineering meets oncology by Carey, Shawn P, D’Alfonso, Timothy M, Shin, Sandra J, Reinhart-King, Cynthia A

“…Highlights ► Tumor invasion, the process by which cells physically dissociate from primary tumors, is a rate-limiting step in metastasis. ► Invasion depends on…”
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Diagnostic utility of MYC amplification and anti-MYC immunohistochemistry in atypical vascular lesions, primary or radiation-induced mammary angiosarcomas, and primary angiosarcomas of other sites by Ginter, Paula S., MD, Mosquera, Juan Miguel, MD, MSc, MacDonald, Theresa Y., BS, D'Alfonso, Timothy M., MD, Rubin, Mark A., MD, Shin, Sandra J., MD

“…Summary Breast cancer patients who receive radiation therapy or develop chronic lymphedema following axillary dissection can develop secondary mammary…”
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ASO Visual Abstract: Effect of Age on Outcomes After Neoadjuvant Chemotherapy for Breast Cancer by Verdial, Francys C., Mamtani, Anita, Pawloski, Kate R., Sevilimedu, Varadan, D’Alfonso, Timothy M., Zhang, Hong, Gemignani, Mary L., Barrio, Andrea V., Morrow, Monica, Tadros, Audree B.

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Cystic Neutrophilic Granulomatous Mastitis: Further Characterization of a Distinctive Histopathologic Entity Not Always Demonstrably Attributable to Corynebacterium Infection by D’Alfonso, Timothy M, Moo, Tracy-Ann, Arleo, Elizabeth K, Cheng, Esther, Antonio, Lilian B, Hoda, Syed A

“…Granulomatous lobular mastitis (GLM) is an uncommon condition that typically occurs in parous, reproductive-aged women and can simulate malignancy on the basis…”
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E-cadherin immunohistochemical expression in invasive lobular carcinoma of the breast: correlation with morphology and CDH1 somatic alterations by Grabenstetter, Anne, Mohanty, Abhinita S., Rana, Satshil, Zehir, Ahmet, Brannon, A. Rose, D'Alfonso, Timothy M., DeLair, Deborah F., Tan, Lee K., Ross, Dara S.

“…E-cadherin (ECAD) immunohistochemical (IHC) expression is lost in ∼90% of invasive lobular carcinomas (ILCs) owing to genomic alterations of CDH1. We examined…”
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Tumor-Nipple Distance of ≥ 1 cm Predicts Negative Nipple Pathology After Neoadjuvant Chemotherapy by Moo, Tracy-Ann, Saccarelli, Carolina Rossi, Sutton, Elizabeth J., Sevilimedu, Varadan, Pawloski, Kate R., D’Alfonso, Timothy M., Hughes, Mary C., Gluskin, Jill S., Bitencourt, Almir, Morris, Elizabeth A., Tadros, Audree, Morrow, Monica, Gemignani, Mary L., Sacchini, Virgilio

“…Background As neoadjuvant chemotherapy (NAC) for breast cancer has become more widely used, so has nipple-sparing mastectomy. A common criterion for…”
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Axl receptor tyrosine kinase expression in breast cancer by D'Alfonso, Timothy M, Hannah, Jeffrey, Chen, Zhengming, Liu, Yifang, Zhou, Pengbo, Shin, Sandra J

“…Triple-negative breast cancer comprises a clinically aggressive group of invasive carcinomas. We examined a published gene expression screen of a panel of…”
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Residual Pure Intralymphatic Breast Carcinoma Following Neoadjuvant Chemotherapy Is Indicative of Poor Clinical Outcome, Even in Node-Negative Patients by Cheng, Esther, Ko, David, Nguyen, Michaela, Moo, Tracy-Ann, Andreopoulou, Eleni, Hoda, Syed A, D’Alfonso, Timothy M

“…Residual carcinoma confined to lymphovascular spaces following neoadjuvant chemotherapy (NAC) for invasive breast carcinoma is an uncommon finding. We studied…”
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Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome by Schwartz, Christopher J, da Silva, Edaise M, Marra, Antonio, Gazzo, Andrea M, Selenica, Pier, Rai, Vikas K, Mandelker, Diana, Pareja, Fresia, Misyura, Maksym, D'Alfonso, Timothy M, Brogi, Edi, Drullinsky, Pamela, Razavi, Pedram, Robson, Mark E, Drago, Joshua Z, Wen, Hannah Y, Zhang, Liying, Weigelt, Britta, Shia, Jinru, Reis-Filho, Jorge S, Zhang, Hong

“…Lynch syndrome is defined by germline pathogenic mutations involving DNA mismatch repair (MMR) genes and linked with the development of MMR-deficient colon and…”
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Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy by Zeng, Jennifer, Edelweiss, Marcia, Ross, Dara S, Xu, Bin, Moo, Tracy-Ann, Brogi, Edi, D'Alfonso, Timothy M

“…It is unclear whether HER2+ tumors expressing both estrogen receptor (ER) and progesterone receptor (PR), that is, triple-positive breast carcinomas (TPBCs),…”
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Interobserver Variation of PD-L1 SP142 Immunohistochemistry Interpretation in Breast Carcinoma: A Study of 79 Cases Using Whole Slide Imaging by Hoda, Raza S, Brogi, Edi, D'Alfonso, Timothy M, Grabenstetter, Anne, Giri, Dilip, Hanna, Matthew G, Kuba, M Gabriela, Murray, Melissa P, Vallejo, Christina E, Zhang, Hong, Reis-Filho, Jorge S, Wen, Hannah Y

“…The Ventana programmed death ligand-1 (PD-L1) SP142 immunohistochemical assay (IHC) is approved by the US Food and Drug Administration as the companion…”
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