Search Results - "D'Alessio, David D"
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The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice
Published in Diabetologia (01-10-2019)“…Aims/hypothesis Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two peptides that function to promote insulin…”
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The anorectic effect of GLP-1 in rats is nutrient dependent
Published in PloS one (17-12-2012)“…GLP-1-induced insulin secretion from the β-cell is dependent upon glucose availability. The purpose of the current study was to determine whether CNS GLP-1…”
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Is GLP‐1 a hormone: Whether and When?
Published in Journal of diabetes investigation (01-04-2016)“…Glucagon‐like peptide‐1 (GLP‐1) is a product of proglucagon cleavage synthesized in L cells in the intestinal mucosa, α‐cells in the pancreatic islet, and…”
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Role of Carbohydrate Modification in Weight Management among Obese Children: A Randomized Clinical Trial
Published in The Journal of pediatrics (01-08-2012)“…Objective To compare the effectiveness and safety of carbohydrate (CHO)-modified diets with a standard portion-controlled (PC) diet in obese children. Study…”
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Impact of intestinal electrical stimulation on nutrient‐induced GLP‐1 secretion in vivo
Published in Neurogastroenterology and motility (01-08-2013)“…Background Increases in L‐cell release of GLP‐1 are proposed to serve as a negative feedback signal for postprandial changes in gastric emptying and/or…”
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High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial
Published in Human psychopharmacology (01-01-2008)“…Objective The purpose of this study was to evaluate the efficacy and safety of high‐dose escitalopram in the treatment of binge‐eating disorder (BED)…”
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Insulin Sensitivity and β-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents
Published in The Journal of pediatrics (01-11-2015)“…Objective To test the hypothesis that insulin secretion and insulin sensitivity would be improved in adolescents after Roux-en-Y gastric bypass (RYGB). Study…”
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Rapid Deterioration of Insulin Secretion in Obese Adolescents Preceding the Onset of Type 2 Diabetes
Published in The Journal of pediatrics (01-03-2015)“…Objective To identify pathophysiologic changes that lead to the onset of type 2 diabetes (T2DM) in adolescents. Study design Obese adolescents with normal…”
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Primary Adrenal Insufficiency from Immune Checkpoint Inhibitors
Published in AACE clinical case reports (01-05-2018)“…Objective: To describe a rare case of primary adrenal insufficiency (PAI) from immune checkpoint inhibitors (ICPIs).Methods: We describe the clinical…”
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Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide
Published in Proceedings of the National Academy of Sciences - PNAS (16-04-1996)“…Pancreatic islet amyloid deposits are a characteristic pathologic feature of non-insulin-dependent diabetes mellitus and contain islet amyloid polypeptide…”
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Mitochondrial dysfunction and insulin resistance: a matter of lifestyle?
Published in Current opinion in clinical nutrition and metabolic care (01-07-2007)Get full text
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How are we going to understand (dys)regulation of glucose metabolism?
Published in Current opinion in clinical nutrition and metabolic care (01-07-2004)Get full text
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β-Cell Dysfunction in Adolescents and Adults with Newly Diagnosed Type 2 Diabetes Mellitus
Published in The Journal of pediatrics (01-06-2012)“…Objective To compare β-cell function in adolescents and adults with newly diagnosed type 2 diabetes (T2DM). Study design Thirty-nine adolescents with T2DM, 38…”
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Glucose Tolerance, Insulin Secretion, and Insulin Sensitivity in Children and Adolescents with Cystic Fibrosis and No Prior History of Diabetes
Published in The Journal of pediatrics (01-12-2007)“…Objective To determine the prevalence of abnormalities of glucose metabolism in pediatric outpatients with cystic fibrosis (CF). Study design Children and…”
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