Search Results - "D'ANTUONO, Tommaso"
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Multicenter Comparison of 22C3 PharmDx (Agilent) and SP263 (Ventana) Assays to Test PD-L1 Expression for NSCLC Patients to Be Treated with Immune Checkpoint Inhibitors
Published in Journal of thoracic oncology (01-11-2017)“…Among the several agents targeting the programmed cell death 1 (PD-1) pathway, pembrolizumab is currently the only one approved for the treatment of patients…”
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Effective Assessment of egfr Mutation Status in Bronchoalveolar Lavage and Pleural Fluids by Next-Generation Sequencing
Published in Clinical cancer research (01-02-2013)“…The therapeutic choice for patients with lung adenocarcinoma depends on the presence of EGF receptor (EGFR) mutations. In many cases, only cytologic samples…”
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Validation of a new algorithm for a quick and easy RT-PCR-based ALK test in a large series of lung adenocarcinomas: comparison with FISH, Immunohistochemistry and next generation sequencing assays
Published in Lung cancer (Amsterdam, Netherlands) (01-09-2016)“…Highlights • A new ALK RGQ RT-PCR assay was validated in a large cohort of lung adenocarcinomas. • The test is simple, rapid and applicable to small biopsies…”
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Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications
Published in BioMed research international (01-01-2013)“…Although HPV-DNA test and E6/E7 mRNA analyses remain the current standard for the confirmation of human papillomavirus (HPV) infections in cytological…”
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Endogenous IL-12 triggers an antiangiogenic program in melanoma cells
Published in Proceedings of the National Academy of Sciences - PNAS (06-03-2007)“…The IL12RB2 gene acts as a tumor suppressor in human B cell malignancies. Indeed, Il12rb2 knockout (KO) mice develop spontaneously B cell tumors, but also lung…”
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Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
Published in Human mutation (01-05-2008)“…The neurotrophic tyrosine receptor kinase (NTRK) family is potentially implicated in tumorigenesis and progression of several neoplastic diseases, including…”
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The Lack of Epithelial Interleukin-7 and BAFF/BLyS Gene Expression in Prostate Cancer as a Possible Mechanism of Tumor Escape from Immunosurveillance
Published in Clinical cancer research (01-05-2009)“…Purpose: The human prostate is endowed with intraepithelial and stromal lymphocytes, which may develop lymphoid follicles (LF) and allow a local immune…”
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ALK Protein Analysis by IHC Staining after Recent Regulatory Changes: A Comparison of Two Widely Used Approaches, Revision of the Literature, and a New Testing Algorithm
Published in Journal of thoracic oncology (01-04-2016)“…Recent regulatory changes have allowed the diagnostic use of immunohistochemical (IHC) analysis for the identification of patients with non-small cell lung…”
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Int6 Expression Can Predict Survival in Early-Stage Non–Small Cell Lung Cancer Patients
Published in Clinical cancer research (01-05-2005)“…Purpose: The Int6 gene was originally identified as a common insertion site for the mouse mammary tumor virus in virally induced mouse mammary tumors. Recent…”
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Detection of nuclear and membrane antigens by liquid-based cytology following long-term storage of d1 cells, karpas cells, and peripheral blood mononuclear cells
Published in Annals of clinical and laboratory science (01-01-2011)“…Immunofluorescence is the most frequently utilized technique to analyze protein expression. Fixed immunofluorescent cell suspensions, however, can only be…”
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First case report of M1 macrophage polarization in an untreated symptomatic patient with toxoplasmosis
Published in BMC infectious diseases (27-03-2018)“…In immunocompetent patients, acute toxoplasmosis is usually asymptomatic. We identified M1 macrophages in a case of symptomatic acute Toxoplasma gondii…”
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Prognostic value of morphologic and morphometric analyses in IgA nephropathy biopsies
Published in Translational medicine communications (21-11-2016)“…Background IgA nephropathy (IgAN) exhibits a variable course ranging from a benign condition to progressive renal failure with a high proportion of patients…”
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Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy
Published in Blood (01-12-2005)“…The interleukin-12 receptor β2 (Il12rb2) gene is silenced in tumor cells from different human B-cell malignancies as opposed to their normal counterparts. It…”
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The prostate-associated lymphoid tissue (PALT) is linked to the expression of homing chemokines CXCL13 and CCL21
Published in The Prostate (01-07-2007)“…BACKGROUND The genitourinary tract is regarded as part of the mucosal immune system. However, the structural and functional aspects of the human…”
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Mammary carcinoma provides highly tumourigenic and invasive reactive stromal cells
Published in Carcinogenesis (New York) (01-11-2005)“…The progression of a lesion to a carcinoma is dependent on the engagement of ‘reactive stroma’ that provides structural and vascular support for tumour growth…”
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Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway
Published in The Journal of pathology (01-01-2005)“…The experimentally induced TS/A murine mammary carcinoma is poorly immunogenic and mainly infiltrated by antigen‐presenting cells (APCs), namely macrophages…”
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The prostate-associated lymphoid tissue (PALT) is linked to the expression of homing chemokines CXCLI3 and CCL21
Published in The Prostate (2007)Get full text
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Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy. Commentary
Published in Blood (2005)Get full text
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Salivary carcinoma in HER‐2/neu transgenic male mice: An angiogenic switch is not required for tumor onset and progression
Published in International journal of cancer (01-11-2000)“…Morphologic examinations of salivary gland neoplasias arising in male BALB/c (H‐2d) mice carrying the activated HER‐2/neu (BALB‐NeuT) indicate that expression…”
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