Search Results - "D'AMATO, Mauro"

Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome by Mars, Ruben A.T., Yang, Yi, Ward, Tonya, Houtti, Mo, Priya, Sambhawa, Lekatz, Heather R., Tang, Xiaojia, Sun, Zhifu, Kalari, Krishna R., Korem, Tal, Bhattarai, Yogesh, Zheng, Tenghao, Bar, Noam, Frost, Gary, Johnson, Abigail J., van Treuren, Will, Han, Shuo, Ordog, Tamas, Grover, Madhusudan, Sonnenburg, Justin, D’Amato, Mauro, Camilleri, Michael, Elinav, Eran, Segal, Eran, Blekhman, Ran, Farrugia, Gianrico, Swann, Jonathan R., Knights, Dan, Kashyap, Purna C.

“…The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been…”
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Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies by Camilleri, Michael, Zhernakova, Alexandra, Bozzarelli, Isotta, D’Amato, Mauro

“…The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably involves genetic predisposition and the effect of environmental factors…”
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Dynamics of the human gut microbiome in inflammatory bowel disease by Halfvarson, Jonas, Brislawn, Colin J., Lamendella, Regina, Vázquez-Baeza, Yoshiki, Walters, William A., Bramer, Lisa M., D'Amato, Mauro, Bonfiglio, Ferdinando, McDonald, Daniel, Gonzalez, Antonio, McClure, Erin E., Dunklebarger, Mitchell F., Knight, Rob, Jansson, Janet K.

“…Inflammatory bowel disease (IBD) is characterized by flares of inflammation with a periodic need for increased medication and sometimes even surgery. The…”
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci by Ellinghaus, David, Jostins, Luke, Spain, Sarah L, Cortes, Adrian, Bethune, Jörn, Han, Buhm, Park, Yu Rang, Raychaudhuri, Soumya, Pouget, Jennie G, Hübenthal, Matthias, Folseraas, Trine, Wang, Yunpeng, Esko, Tonu, Metspalu, Andres, Westra, Harm-Jan, Franke, Lude, Pers, Tune H, Weersma, Rinse K, Collij, Valerie, D'Amato, Mauro, Halfvarson, Jonas, Jensen, Anders Boeck, Lieb, Wolfgang, Degenhardt, Franziska, Forstner, Andreas J, Hofmann, Andrea, Schreiber, Stefan, Mrowietz, Ulrich, Juran, Brian D, Lazaridis, Konstantinos N, Brunak, Søren, Dale, Anders M, Trembath, Richard C, Weidinger, Stephan, Weichenthal, Michael, Ellinghaus, Eva, Elder, James T, Barker, Jonathan N W N, Andreassen, Ole A, McGovern, Dermot P, Karlsen, Tom H, Barrett, Jeffrey C, Parkes, Miles, Brown, Matthew A, Franke, Andre

“…David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight…”
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Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota by Wang, Jun, Thingholm, Louise B, Skiecevičienė, Jurgita, Rausch, Philipp, Kummen, Martin, Hov, Johannes R, Degenhardt, Frauke, Heinsen, Femke-Anouska, Rühlemann, Malte C, Szymczak, Silke, Holm, Kristian, Esko, Tönu, Sun, Jun, Pricop-Jeckstadt, Mihaela, Al-Dury, Samer, Bohov, Pavol, Bethune, Jörn, Sommer, Felix, Ellinghaus, David, Berge, Rolf K, Hübenthal, Matthias, Koch, Manja, Schwarz, Karin, Rimbach, Gerald, Hübbe, Patricia, Pan, Wei-Hung, Sheibani-Tezerji, Raheleh, Häsler, Robert, Rosenstiel, Philipp, D'Amato, Mauro, Cloppenborg-Schmidt, Katja, Künzel, Sven, Laudes, Matthias, Marschall, Hanns-Ulrich, Lieb, Wolfgang, Nöthlings, Ute, Karlsen, Tom H, Baines, John F, Franke, Andre

“…Andre Franke and colleagues perform a genome-wide association study for the gut microbiome, examining the influence of host genetics on overall microbial…”
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A Starch- and Sucrose-Reduced Diet in Irritable Bowel Syndrome Leads to Lower Circulating Levels of PAI-1 and Visfatin: A Randomized Controlled Study by Roth, Bodil, Myllyvainio, Julia, D'Amato, Mauro, Larsson, Ewa, Ohlsson, Bodil

“…Irritable bowel syndrome (IBS) is characterized by gastrointestinal symptoms. Overweight and increased risk of metabolic syndromes/diabetes are observed in…”
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Hypomorphic SI genetic variants are associated with childhood chronic loose stools by Chumpitazi, Bruno P, Lewis, Jeffery, Cooper, Derick, D'Amato, Mauro, Lim, Joel, Gupta, Sandeep, Miranda, Adrian, Terry, Natalie, Mehta, Devendra, Scheimann, Ann, O'Gorman, Molly, Tipnis, Neelesh, Davies, Yinka, Friedlander, Joel, Smith, Heather, Punati, Jaya, Khlevner, Julie, Setty, Mala, Di Lorenzo, Carlo

“…The SI gene encodes the sucrase-isomaltase enzyme, a disaccharidase expressed in the intestinal brush border. Hypomorphic SI variants cause recessive…”
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Functional Analyses of the Crohn's Disease Risk Gene LACC1 by Assadi, Ghazaleh, Vesterlund, Liselotte, Bonfiglio, Ferdinando, Mazzurana, Luca, Cordeddu, Lina, Schepis, Danika, Mjösberg, Jenny, Ruhrmann, Sabrina, Fabbri, Alessia, Vukojevic, Vladana, Percipalle, Piergiorgio, Salomons, Florian A, Laurencikiene, Jurga, Törkvist, Leif, Halfvarson, Jonas, D'Amato, Mauro

“…Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy…”
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Gastrointestinal Infection and Risk of Microscopic Colitis: A Nationwide Case-Control Study in Sweden by Khalili, Hamed, Axelrad, Jordan E., Roelstraete, Bjorn, Olén, Ola, D’Amato, Mauro, Ludvigsson, Jonas F.

“…Gastrointestinal infections have been linked to changes in the composition and function of gut microbiome and development of inflammatory bowel diseases. We…”
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Systemic Inflammation in Preclinical Ulcerative Colitis by Bergemalm, Daniel, Andersson, Erik, Hultdin, Johan, Eriksson, Carl, Rush, Stephen T., Kalla, Rahul, Adams, Alex T., Keita, Åsa V., D’Amato, Mauro, Gomollon, Fernando, Jahnsen, Jørgen, Arnott, Ian D., Bayes, Monica, Bonfiglio, Ferdinando, Boyapati, Ray K., Carstens, Adam, Casén, Christina, Ciemniejewska, Ewa, Dahl, Fredrik A., Detlie, Trond Espen, Drummond, Hazel E., Ekeland, Gunn S., Ekman, Daniel, Frengen, Anna B., Gullberg, Mats, Gut, Ivo G., Gut, Marta, Heath, Simon C., Hjelm, Fredrik, Hjortswang, Henrik, Ho, Gwo-Tzer, Jonkers, Daisy, Söderholm, Johan, Kennedy, Nicholas A., Lees, Charles W., Lindahl, Torbjørn, Lindqvist, Mårten, Merkel, Angelika, Modig, Eddie, Moen, Aina E.F., Nilsen, Hilde, Nimmo, Elaine R., Noble, Colin L., Nordberg, Niklas, O’Leary, Kate R., Ocklind, Anette, Olbjørn, Christine, Pettersson, Erik, Pierik, Marieke, Dominique, Ricanek, Petr, Satsangi, Jack, Repsilber, Dirk, Karling, Pontus, Halfvarson, Jonas

“…Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive…”
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Crohn’s Disease Is Associated With Activation of Circulating Innate Lymphoid Cells by Mazzurana, Luca, Bonfiglio, Ferdinando, Forkel, Marianne, D’Amato, Mauro, Halfvarson, Jonas, Mjösberg, Jenny

“…Abstract Background Inflammatory bowel disease (IBD) is associated with disturbed mucosal innate lymphoid cell (ILC) composition, which is correlated to the…”
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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease by Rivas, Manuel A, Daly, Mark J, Beaudoin, Mélissa, Gardet, Agnes, Stevens, Christine, Sharma, Yashoda, Zhang, Clarence K, Boucher, Gabrielle, Ripke, Stephan, Ellinghaus, David, Burtt, Noel, Fennell, Tim, Kirby, Andrew, Latiano, Anna, Goyette, Philippe, Green, Todd, Halfvarson, Jonas, Haritunians, Talin, Korn, Joshua M, Kuruvilla, Finny, Lagacé, Caroline, Neale, Benjamin, Lo, Ken Sin, Schumm, Phil, Törkvist, Leif, Dubinsky, Marla C, Brant, Steven R, Silverberg, Mark S, Duerr, Richard H, Altshuler, David, Gabriel, Stacey, Lettre, Guillaume, Franke, Andre, D'Amato, Mauro, McGovern, Dermot P B, Cho, Judy H, Rioux, John D, Xavier, Ramnik J

“…Mark Daly, Manuel Rivas and colleagues used next-generation sequencing to study the coding exons of 56 genes from regions previously associated with Crohn's…”
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Sucrase isomaltase dysfunction reduces sucrose intake in mice and humans by Aldiss, Peter, Torices, Leire, Ramne, Stina, Jørgensen, Marit Eika, Bonfiglio, Ferdinando, Burm, Hayley, Blanco, Cristina Esteban, Vinggaard Stæger, Frederik Filip, Senftleber, Ninna Karsbæk, Treebak, Jonas T., Grarup, Niels, Bjerregaard, Peter, Grevengoed, Trisha J., Gillum, Matthew P., Moltke, Ida, Albrechtsen, Anders, Hansen, Torben, D’Amato, Mauro, Andersen, Mette K.

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European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations by Miehlke, Stephan, Guagnozzi, Danila, Zabana, Yamile, Tontini, Gian E., Kanstrup Fiehn, Anne‐Marie, Wildt, Signe, Bohr, Johan, Bonderup, Ole, Bouma, Gerd, D'Amato, Mauro, Heiberg Engel, Peter J., Fernandez‐Banares, Fernando, Macaigne, Gilles, Hjortswang, Henrik, Hultgren‐Hörnquist, Elisabeth, Koulaouzidis, Anastasios, Kupcinskas, Jouzas, Landolfi, Stefania, Latella, Giovanni, Lucendo, Alfredo, Lyutakov, Ivan, Madisch, Ahmed, Magro, Fernando, Marlicz, Wojciech, Mihaly, Emese, Munck, Lars K., Ostvik, Ann‐Elisabeth, Patai, Árpád V., Penchev, Plamen, Skonieczna‐Żydecka, Karolina, Verhaegh, Bas, Münch, Andreas

“…Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic…”
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Functional Variation in Human CAZyme Genes in Relation to the Efficacy of a Carbohydrate-Restricted Diet in IBS Patients by Zamfir-Taranu, Andreea, Löscher, Britt-Sabina, Carbone, Florencia, Hoter, Abdullah, Esteban Blanco, Cristina, Bozzarelli, Isotta, Torices, Leire, Routhiaux, Karen, Van den Houte, Karen, Bonfiglio, Ferdinando, Mayr, Gabriele, Corsetti, Maura, Naim, Hassan Y., Franke, Andre, Tack, Jan, D’Amato, Mauro

“…Limiting the dietary intake of certain carbohydrates has therapeutic effects in some but not all irritable bowel syndrome (IBS) patients. We investigated…”
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C13orf31 (FAMIN) is a central regulator of immunometabolic function by Cader, M Zaeem, Boroviak, Katharina, Zhang, Qifeng, Assadi, Ghazaleh, Kempster, Sarah L, Sewell, Gavin W, Saveljeva, Svetlana, Ashcroft, Jonathan W, Clare, Simon, Mukhopadhyay, Subhankar, Brown, Karen P, Tschurtschenthaler, Markus, Raine, Tim, Doe, Brendan, Chilvers, Edwin R, Griffin, Jules L, Kaneider, Nicole C, Floto, R Andres, D'Amato, Mauro, Bradley, Allan, Wakelam, Michael J O, Dougan, Gordon, Kaser, Arthur

“…Variants of the human gene C13orf31 ( LACC1 ) are associated with various disease risks. Kaser and colleagues identify a role for the protein encoded (called…”
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A starch‐ and sucrose‐reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro‐RNA levels by Nilholm, Clara, Manoharan, Lokeshwaran, Roth, Bodil, D’Amato, Mauro, Ohlsson, Bodil

“…Background/Aim A randomized clinical trial with a starch‐ and sucrose‐reduced diet (SSRD) in irritable bowel syndrome (IBS) patients has shown clear…”
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The history of genetics in inflammatory bowel disease by Ek, Weronica E, D'Amato, Mauro, Halfvarson, Jonas

“…The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially demonstrated by epidemiological data, including differences in…”
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Detection of Celiac Disease and Lymphocytic Enteropathy by Parallel Serology and Histopathology in a Population-Based Study by Walker, Marjorie M, Murray, Joseph A, Ronkainen, Jukka, Aro, Pertti, Storskrubb, Tom, D'Amato, Mauro, Lahr, Brian, Talley, Nicholas J, Agreus, Lars

“…Background & Aims Although serologic analysis is used in diagnosis of celiac disease, histopathology is considered most reliable. We performed a prospective…”
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A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition by Li, Dalin, Achkar, Jean-Paul, Haritunians, Talin, Jacobs, Jonathan P, Hui, Ken Y, D'Amato, Mauro, Brand, Stephan, Radford-Smith, Graham, Halfvarson, Jonas, Niess, Jan-Hendrik, Kugathasan, Subra, Büning, Carsten, Schumm, L. Philip, Klei, Lambertus, Ananthakrishnan, Ashwin, Aumais, Guy, Baidoo, Leonard, Dubinsky, Marla, Fiocchi, Claudio, Glas, Jürgen, Milgrom, Raquel, Proctor, Deborah D, Regueiro, Miguel, Simms, Lisa A, Stempak, Joanne M, Targan, Stephan R, Törkvist, Leif, Sharma, Yashoda, Devlin, Bernie, Borneman, James, Hakonarson, Hakon, Xavier, Ramnik J, Daly, Mark, Brant, Steven R, Rioux, John D, Silverberg, Mark S, Cho, Judy H, Braun, Jonathan, McGovern, Dermot P.B, Duerr, Richard H

“…Background & Aims Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn’s disease…”
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