Search Results - "Czyzyk, Traci A."

Targeted Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet-Induced Liver Steatosis by XIAODONG ZHANG, XITAO XIE, HECKMANN, Bradlee L, SAARINEN, Alicia M, CZYZYK, Traci A, JUN LIU

“…Recent biochemical and cell-based studies identified G0/G1 switch gene 2 (G0S2) as an inhibitor of adipose triglyceride lipase (ATGL), a key mediator of…”
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Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations by Zheng, Ruimao, Yang, Linghai, Sikorski, Maria A, Enns, Linda C, Czyzyk, Traci A, Ladiges, Warren C, McKnight, G Stanley

“…Targeted disruption of RIIβ-protein kinase A (PKA) in mice leads to a lean phenotype, increased nocturnal locomotor activity, and activation of brown adipose…”
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Antisense oligonucleotide‐mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet‐induced obesity in mice by Worley, Beth L., Auen, Thomas, Arnold, Amy C., Monia, Brett P., Hempel, Nadine, Czyzyk, Traci A.

“…Previously, we demonstrated that global knockout (KO) of the gene encoding myelin protein zero‐like 3 (Mpzl3) results in reduced body weight and adiposity,…”
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Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor Diabetic by Marcus, David J, Zee, Michael L, Davis, Brian J, Haskins, Chris P, Andrews, Mary-Jeanette, Amin, Randa, Henderson-Redmond, Angela N, Mackie, Ken, Czyzyk, Traci A, Morgan, Daniel J

“…Multiple lines of evidence implicate the endocannabinoid signaling system in the modulation of metabolic disease. Genetic or pharmacological inactivation of…”
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Disruption of the RIIβ subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice by Czyzyk, Traci A, Sikorski, Maria A, Yang, Linghai, McKnight, G. Stanley

“…Agouti lethal yellow (Ay) mice express agouti ectopically because of a genetic rearrangement at the agouti locus. The agouti peptide is a potent antagonist of…”
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Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology by Wikramanayake, Tongyu C., Nicu, Carina, Chéret, Jérémy, Czyzyk, Traci A., Paus, Ralf

“…MPZL3 is a nuclear‐encoded, mitochondrially localized, immunoglobulin‐like V‐type protein that functions as a key regulator of epithelial cell differentiation,…”
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Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance by McLaughlin, Jay P., Myers, Lisa C., Zarek, Paul E., Caron, Marc G., Lefkowitz, Robert J., Czyzyk, Traci A., Pintar, John E., Chavkin, Charles

“…Kappa opioid receptor (KOR) desensitization was previously shown to follow agonist-dependent phosphorylation of serine 369 by G-protein receptor kinase (GRK)…”
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GOAT links dietary lipids with the endocrine control of energy balance by Tschöp, Matthias H, Kirchner, Henriette, Gutierrez, Jesus A, Solenberg, Patricia J, Pfluger, Paul T, Czyzyk, Traci A, Willency, Jill A, Schürmann, Annette, Joost, Hans-Georg, Jandacek, Ronald J, Hale, John E, Heiman, Mark L

“…Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy…”
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A Model of Binge-Like Eating Behavior in Mice That Does Not Require Food Deprivation or Stress by Czyzyk, Traci A., Sahr, Allison E., Statnick, Michael A.

“…Binge eating disorder (BED) is characterized by excessive food intake during a short period of time and is often associated with obesity. Mouse models of…”
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PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice by Chen, Yi-Chun, Mains, Richard E., Eipper, Betty A., Hoffman, Brad G., Czyzyk, Traci A., Pintar, John E., Verchere, C. Bruce

“…Aims/hypothesis Peptide hormones are first synthesised as larger, inactive precursors that are converted to their active forms by endopeptidase cleavage and…”
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Mice lacking δ‐opioid receptors resist the development of diet‐induced obesity by Czyzyk, Traci A., Romero‐Picó, Amparo, Pintar, John, McKinzie, Jaime H., Tschöp, Matthias H., Statnick, Michael A., Nogueiras, Ruben

“…ABSTRACT Pharmacological manipulation of opioid receptors alters feeding behavior. However, the individual contributions of each opioid receptor subtype on…”
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Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice by Morgan, Daniel J, Davis, Brian J, Kearn, Chris S, Marcus, David, Cook, Alex J, Wager-Miller, Jim, Straiker, Alex, Myoga, Michael H, Karduck, Jeffrey, Leishman, Emma, Sim-Selley, Laura J, Czyzyk, Traci A, Bradshaw, Heather B, Selley, Dana E, Mackie, Ken

“…For many G-protein-coupled receptors (GPCRs), including cannabinoid receptor 1 (CB1R), desensitization has been proposed as a principal mechanism driving…”
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Correction to: PAM haploinsufficiency does not accelerate the development of diet and human IAPP-induced diabetes in mice by Chen, Yi-Chun, Mains, Richard E., Eipper, Betty A., Hoffman, Brad G., Czyzyk, Traci A., Pintar, John E., Verchere, C. Bruce

“…Unfortunately, the human islet checklist was omitted from the electronic supplementary material (ESM) linked to this paper…”
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Alterations in nociception and morphine antinociception in mice fed a high-fat diet by Nealon, Caitlin M., Patel, Chandni, Worley, Beth L., Henderson-Redmond, Angela N., Morgan, Daniel J., Czyzyk, Traci A.

“…•Females are less responsive to the antinociceptive effects of morphine than male littermates.•HED increases tolerance to the antinociceptive effects of…”
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κ‐Opioid receptors control the metabolic response to a high‐energy diet in mice by Czyzyk, Traci A., Nogueiras, Ruben, Lockwood, John F., McKinzie, Jamie H., Coskun, Tamer, Pintar, John E., Hammond, Craig, Tschöp, Matthias H., Statnick, Michael A.

“…ABSTRACT General opioid receptor antagonists reduce food intake and body weight in rodents, but the contributions of specific receptor subtypes are unknown. We…”
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Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse by Czyzyk, Traci A., Ning, Yun, Hsu, Ming-Sing, Peng, Bonnie, Mains, Richard E., Eipper, Betty A., Pintar, John E.

“…Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-terminal amidation of peptide hormones. We previously had found high expression of PAM…”
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Genetic ablation of myelin protein zero-like 3 in mice increases energy expenditure, improves glycemic control, and reduces hepatic lipid synthesis by Czyzyk, Traci A, Andrews, Jessica L, Coskun, Tamer, Wade, Mark R, Hawkins, Eric D, Lockwood, John F, Varga, Gabor, Sahr, Allison E, Chen, Yanyun, Brozinick, Joseph T, Kikly, Kristine, Statnick, Michael A

“…Obesity continues to be a global health problem, and thus it is imperative that new pathways regulating energy balance be identified. Recently, it was…”
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CNS Opioid Signaling Separates Cannabinoid Receptor 1-Mediated Effects on Body Weight and Mood-Related Behavior in Mice by Lockie, Sarah Haas, Czyzyk, Traci A, Chaudhary, Nilika, Perez-Tilve, Diego, Woods, Stephen C, Oldfield, Brian J, Statnick, Michael A, Tschöp, Matthias H

“…Existing monotherapies for the treatment of obesity provide only modest weight loss and/or have adverse side effects, and this is also the case with the…”
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Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance by Xu, Mei, Petraschka, Michael, McLaughlin, Jay P, Westenbroek, Ruth E, Caron, Marc G, Lefkowitz, Robert J, Czyzyk, Traci A, Pintar, John E, Terman, Gregory W, Chavkin, Charles

“…Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain…”
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Targeted mutagenesis of processing enzymes and regulators: Implications for development and physiology by Czyzyk, Traci A., Morgan, Daniel J., Peng, Bonnie, Zhang, Jiwen, Karantzas, Alexander, Arai, Maya, Pintar, John E.

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