Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32)

Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/cyclin D1 dua...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 171; no. 2; pp. 101 - 104
Main Authors:	Rashid, Rumana, Johnson, Roderick J., Morris, Stephen, Dickinson, Helen, Czyz, Jarek, O'Connor, Sheila J.M., Owen, Roger G.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2006
Subjects:	Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 14 DNA-Binding Proteins - genetics Female Humans Karyotyping Lymphoma, B-Cell - genetics Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Middle Aged Polyploidy Proto-Oncogene Proteins c-bcl-6 Translocation, Genetic Tumor Cells, Cultured Vascular Neoplasms - genetics Vascular Neoplasms - pathology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/cyclin D1 dual-color, dual-fusion probe set and cyclin D1 immunohistochemical analysis. Abnormality of 3q was also evident. Interphase FISH analysis with a dual-color, break-apart probe set confirmed rearrangement of BCL6. To our knowledge, this is the first report of these abnormalities in IVL.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0165-4608 1873-4456
DOI:	10.1016/j.cancergencyto.2006.07.018