Search Results - "Czysz, Katherine"

DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation by Czysz, Katherine, Minger, Stephen, Thomas, Nick

“…Definitive endoderm (DE) is one of the three germ layers which during in vivo vertebrate development gives rise to a variety of organs including liver, lungs,…”
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Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug Discovery by Hosoya, Masaki, Czysz, Katherine

“…Despite continuous efforts to improve the process of drug discovery and development, achieving success at the clinical stage remains challenging because of a…”
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iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery by Gurevich, Igor, Burton, Sarah A, Munn, Christie, Ohshima, Makiko, Goedland, Madelyn E, Czysz, Katherine, Rajesh, Deepika

“…Non-alcoholic fatty liver disease (NAFLD) affects 30-40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic…”
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Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations by Gintant, Gary, Kaushik, Emily Pfeiffer, Feaster, Tromondae, Stoelzle-Feix, Sonja, Kanda, Yasunari, Osada, Tomoharu, Smith, Godfrey, Czysz, Katherine, Kettenhofen, Ralf, Lu, Hua Rong, Cai, Beibei, Shi, Hong, Herron, Todd Joseph, Dang, Qianyu, Burton, Francis, Pang, Li, Traebert, Martin, Abassi, Yama, Pierson, Jennifer Beck, Blinova, Ksenia

“…Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on…”
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Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells by Pistollato, Francesca, Bal-Price, Anna, Coecke, Sandra, Parvatam, Surat, Pamies, David, Czysz, Katherine, Hao, Jie, Kee, Kehkooi, Teo, Adrian Kee Keong, Niu, Shuaishuai, Wilmes, Anja, Smirnova, Lena, Freund, Christian, Mummery, Christine, Stacey, Glyn

“…The advent of the technology to isolate or generate human pluripotent stem cells provided the potential to develop a wide range of human models that could…”
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Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile by Huang, Kai-Wen, Reebye, Vikash, Czysz, Katherine, Ciriello, Simona, Dorman, Stephanie, Reccia, Isabella, Lai, Hong-Shiee, Peng, Ling, Kostomitsopoulos, Nikos, Nicholls, Joanna, Habib, Robert S., Tomalia, Donald A., Sætrom, Pål, Wilkes, Edmund, Cutillas, Pedro, Rossi, John J., Habib, Nagy A.

“…Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment…”
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iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery by Gurevich, Igor, Burton, Sarah A, Munn, Christie, Ohshima, Makiko, Goedland, Madelyn E, Czysz, Katherine, Rajesh, Deepika

“…Non-alcoholic fatty liver disease (NAFLD) affects 30 to 40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic…”
Get full text

Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model by Reebye, Vikash, Huang, Kai-Wen, Czysz, Katherine, Ciriello, Simona, Dorman, Stehpanie, Reccia, Isabella, Lai, H. S., Peng, Ling, Kostomitsopoulos, Nikos, Nicholls, Joanna, Habib, Robert, Tomalia, Donald, Saetrom, Pal, Wilkes, Edmund, Cutillas, Pedro, Rossi, John, Habib, Nagy

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DMSO Efficiently Down Regulates Pluripotency Genes in Human Embryonic Stem Cells during Definitive Endoderm Derivation and Increases the Proficiency of Hepatic Differentiation: e0117689 by Czysz, Katherine, Minger, Stephen, Thomas, Nick

“…Background Definitive endoderm (DE) is one of the three germ layers which during in vivo vertebrate development gives rise to a variety of organs including…”
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