Search Results - "Czich, A"

Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches by Teixidó, E., Krupp, E., Amberg, A., Czich, A., Scholz, S.

“…•Study comparison based entirely on publically available data.•An overall similar sensitivity of developmental toxicity in rat and rabbits was confirmed.•Only…”
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Letter to the editor by Zeller, A., Czich, A., Guérard, M., Honarvar, N., Martus, H.-J., Pfuhler, S., Vock, E., Kirkland, D.

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Enhancing compound safety assessment using “Multitask” deep neural nets by Wenzel, J., Anger, L., Amberg, A., Matter, H., Hessler, G., Griesang, N., Mertsch, K., Czich, A., Schmidt, F.

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A critical appraisal of the sensitivity of in vivo genotoxicity assays in detecting human carcinogens by Zeller, Andreas, Pfuhler, Stefan, Albertini, Silvio, Bringezu, Frank, Czich, Andreas, Dietz, Yasmin, Fautz, Rolf, Hewitt, Nicola J, Kirst, Annette, Kasper, Peter

“…Genotoxicity testing is an important part of standard safety testing strategies. Animal studies have always been a key component, either as a mandatory part of…”
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Letter to the editor by Zeller, A, Czich, A, Guérard, M, Honarvar, N, Martus, H-J, Pfuhler, S, Vock, E, Kirkland, D

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Photochemical genotoxicity: principles and test methods: Report of a GUM task force by Brendler-Schwaab, Susanne, Czich, Andreas, Epe, Bernd, Gocke, Elmar, Kaina, Bernd, Müller, Lutz, Pollet, Dieter, Utesch, Dietmar

“…In recent years, assessing the photogenotoxic potential of a compound became an issue for certain drugs and cosmetical products. Therefore, existing methods…”
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Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in Escherichia coli by Glatt, Hansruedi, Pauly, Karin, Czich, Andreas, Falany, Josie L., Falany, Charles N.

“…Human hydroxysteroid sulfotransferase, human phenol-sulfating form of phenol sulfotransferase, rat hydroxysteroid sulfotransferase a and rat phenol…”
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Stable heterologous expression of hydroxysteroid sulphotransferase in Chinese hamster V79 cells and their use for toxicological investigations by Czich, A, Bartsch, I, Dogra, S, Hornhardt, S, Glatt, H R

“…Various benzylic alcohols are metabolically activated to electrophilic, potentially mutagenic and carcinogenic sulphuric acid esters. The involved…”
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Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases by Glatt, Hansruedi, Bartsch, Ingrid, Czich, Andreas, Seidel, Albrecht, Falany, Charles N.

“…Rat and human sulfotransferases (STs) were expressed in his − S. typhimurium strains. These new bacterial strains detected various mutagens which are difficult…”
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Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continuous cell cultures by Glatt, H, Pauly, K, Piée-Staffa, A, Seidel, A, Hornhardt, S, Czich, A

“…Various environmental chemicals are metabolised to chemically reactive sulfuric acid esters, which may covalently bind to cellular macromolecules and induce…”
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1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects by Glatt, H, Werle-Schneider, G, Enders, N, Monnerjahn, S, Pudil, J, Czich, A, Seidel, A, Schwarz, M

“…1-Hydroxymethylpyrene (HMP) is activated to a potent mutagen, detectable in Salmonella typhimurium, in the presence of hepatic cytosol, cofactor for…”
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