Search Results - "Czernik, A J"

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons by Greengard, Paul, Bibb, James A, Snyder, Gretchen L, Nishi, Akinori, Yan, Zhen, Meijer, Laurent, Fienberg, Allen A, Tsai, Li-Huei, Kwon, Young T, Girault, Jean-Antoine, Czernik, Andrew J, Huganir, Richard L, Hemmings, Hugh C, Nairn, Angus C

“…The physiological state of the cell is controlled by signal transduction mechanisms which regulate the balance between protein kinase and protein phosphatase…”
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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function by Greengard, Paul, Valtorta, Flavia, Czernik, Andrew J., Benfenati, Fabio

“…Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the…”
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Distinct pools of synaptic vesicles in neurotransmitter release by Pieribone, Vincent A, Shupliakov, Oleg, Brodin, Lennart, Hilfiker-Rothenfluh, Sabine, Czernik, Andrew J, Greengard, Paul

“…Nerve terminals are unique among cellular secretory systems in that they can sustain vesicular release at a high rate. Although little is known about the…”
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Neurotrophins Stimulate Phosphorylation of Synapsin I by MAP Kinase and Regulate Synapsin I-Actin Interactions by Jovanovic, Jasmina N., Benfenati, Fabio, Siow, Law L., Sihra, Talvinder S., Sanghera, Jasbinder S., Pelech, Steven L., Greengard, Paul, Czernik, Andrew J.

“…The ability of neurotrophins to modulate the survival and differentiation of neuronal populations involves the Trk/MAP (mitogen-activated protein kinase)…”
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Processing of Alzheimer β/A4 Amyloid Precursor Protein: Modulation by Agents that Regulate Protein Phosphorylation by Buxbaum, Joseph D., Gandy, Samuel E., Cicchetti, Piera, Ehrlich, Michelle E., Czernik, Andrew J., Fracasso, R. Paul, Ramabhadran, Triprayar V., Unterbeck, Axel J., Greengard, Paul

“…The turnover and processing of the Alzheimer β/A4 amyloid precursor protein (βAPP) has been studied in PC12 cells after treatment with agents that regulate…”
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Regulation of Synaptotagmin I Phosphorylation by Multiple Protein Kinases by Hilfiker, Sabine, Pieribone, Vincent A., Nordstedt, Christer, Greengard, Paul, Czernik, Andrew J.

“…: Synaptotagmin I has been suggested to function as a low‐affinity calcium sensor for calcium‐triggered exocytosis from neurons and neuroendocrine cells. We…”
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Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine by Snyder, GL, Girault, JA, Chen, JY, Czernik, AJ, Kebabian, JW, Nathanson, JA, Greengard, P

“…The molecular mechanisms underlying regulation of fluid production by secretory epithelia such as the choroid plexus are poorly understood. Two cAMP-regulated…”
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Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis by G Fisone, S X Cheng, A C Nairn, A J Czernik, H C Hemmings, Jr, J O Höög, A M Bertorello, R Kaiser, T Bergman, H Jörnvall

“…Phosphorylation of purified Na+,K(+)-ATPase by cAMP-dependent protein kinase (protein kinase A) decreases the activity of this enzyme. We have now shown, using…”
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Identification of synapsin I peptides that insert into lipid membranes by Cheetham, J J, Hilfiker, S, Benfenati, F, Weber, T, Greengard, P, Czernik, A J

“…The synapsins constitute a family of synaptic vesicle-associated phosphoproteins essential for regulating neurotransmitter release and synaptogenesis. The…”
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Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein by Suzuki, T., Oishi, M., Marshak, D.R., Czernik, A.J., Nairn, A.C., Greengard, P.

“…Accumulation of the amyloid A beta peptide, which is derived from a larger precursor protein (APP), and the formation of plaques, are major events believed to…”
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Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I by BENFENATI, F, VALTORTA, F, RUBENSTEIN, J. L, GORELICK, F. S, GREENGARD, P, CZERNIK, A. J

“…Synapsin I is a synaptic vesicle-associated phosphoprotein that is involved in the modulation of neurotransmitter release. Ca2+/calmodulin-dependent protein…”
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Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade by Desdouits‐Magnen, Juliette, Desdouits, Frédéric, Takeda, Shizu, Syu, Li‐Jyun, Saltiel, Alan R., Buxbaum, Joseph D., Czernik, Andrew J., Nairn, Angus C., Greengard, Paul

“…: Activation of protein kinase C (PKC) regulates the processing of Alzheimer amyloid precursor protein (APP) into its soluble form (sAPP) and amyloid β‐peptide…”
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Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site by Picciotto, M R, Czernik, A J, Nairn, A C

“…Ca2+/calmodulin-dependent protein kinase I (CaM kinase I) was previously purified from bovine brain (Nairn, A. C., and Greengard, P. (1987) J. Biol. Chem. 262,…”
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Interaction of Grb2 via its Src Homology 3 Domains with Synaptic Proteins Including Synapsin I by McPherson, Peter S., Czernik, Andrew J., Chilcote, Tamie J., Onofri, Franco, Benfenati, Fabio, Greengard, Paul, Schlessinger, Joseph, de Camilli, Pietro

“…Grb2 is a 25-kDa adaptor protein composed of a Src homology 2 (SH2) domain and two flanking Src homology 3 (SH3) domains. One function of Grb2 is to couple…”
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Amino Acid Sequences Surrounding the cAMP-Dependent and Calcium/Calmodulin-Dependent Phosphorylation Sites in Rat and Bovine Synapsin I by Czernik, Andrew J., Pang, Dennis T., Greengard, Paul

“…The amino acid sequences surrounding three major phosphorylation sites in rat and bovine synapsin I have been determined by employing automated gas-phase…”
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The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells by Oishi, M, Nairn, A C, Czernik, A J, Lim, G S, Isohara, T, Gandy, S E, Greengard, P, Suzuki, T

“…The cytoplasmic domain of the Alzheimer's disease amyloid precursor protein (APP) is phosphorylated in vitro at Thr654 and Ser655, and both in vitro and in…”
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Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain by Walaas, S I, Czernik, A J, Olstad, O K, Sletten, K, Walaas, O

“…Phospholemman, a transmembrane, 72 residue protein enriched in striated muscle and heart [Palmer, Scott and Jones (1991) J. Biol. Chem. 266, 11126-11130], is…”
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Increase in synapsin I phosphorylation implicates a presynaptic component in septal kindling by Yamagata, Y., Obata, K., Greengard, P., Czernik, A.J.

“…Synaptic plasticity in the CNS is thought to be an important component of learning and memory. 12Kindling is an animal model of synaptic plasticity in which…”
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Synapsins as mediators of BDNF-enhanced neurotransmitter release by Sihra, Talvinder S, Jovanovic, Jasmina N, Czernik, Andrew J, Fienberg, Allen A, Greengard, Paul

“…We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor…”
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Characterization of Synapsin I Fragments Produced by Cysteine-Specific Cleavage: A Study of Their Interactions with F-Actin by Bähler, Martin, Benfenati, Fabio, Valtorta, Flavia, Czernik, Andrew J., Greengard, Paul

“…Synapsin I is a neuron-specific phospho-protein that is concentrated in the presynaptic nerve terminal in association with the cytoplasmic surface of synaptic…”
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