Search Results - "Czarnota, Gregory"

Comment in reply to Chen et al. Journal of Neuro-Oncology (2023) 165:535–545 “Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study” by Czarnota, Gregory J.

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Overview of Therapeutic Ultrasound Applications and Safety Considerations by Miller, Douglas L., Smith, Nadine B., Bailey, Michael R., Czarnota, Gregory J., Hynynen, Kullervo, Makin, Inder Raj S.

“…Applications of ultrasound in medicine for therapeutic purposes have been accepted and beneficial uses of ultrasonic biological effects for many years…”
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Application of Ultrasound Combined with Microbubbles for Cancer Therapy by Sharma, Deepa, Leong, Kai Xuan, Czarnota, Gregory J

“…At present, cancer is one of the leading causes of death worldwide. Treatment failure remains one of the prime hurdles in cancer treatment due to the…”
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Involvement of Ceramide Signalling in Radiation-Induced Tumour Vascular Effects and Vascular-Targeted Therapy by Sharma, Deepa, Czarnota, Gregory J.

“…Sphingolipids are well-recognized critical components in several biological processes. Ceramides constitute a class of sphingolipid metabolites that are…”
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Comparison of methods for texture analysis of QUS parametric images in the characterization of breast lesions by Osapoetra, Laurentius O, Chan, William, Tran, William, Kolios, Michael C, Czarnota, Gregory J

“…Accurate and timely diagnosis of breast carcinoma is very crucial because of its high incidence and high morbidity. Screening can improve overall prognosis by…”
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Blood brain barrier opening is not just blood-brain barrier opening by Sharma, Deepa, Czarnota, Gregory J

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Ultrasound-stimulated microbubble radiation enhancement of tumors: Single-dose and fractionated treatment evaluation by McNabb, Evan, Al-Mahrouki, Azza, Law, Niki, McKay, Scott, Tarapacki, Christine, Hussein, Farah, Czarnota, Gregory J

“…The use of ultrasound-stimulated microbubble therapy has successfully been used to target tumor vasculature and enhance the effects of radiation therapy in…”
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Quantitative ultrasound radiomics for therapy response monitoring in patients with locally advanced breast cancer: Multi-institutional study results by Quiaoit, Karina, DiCenzo, Daniel, Fatima, Kashuf, Bhardwaj, Divya, Sannachi, Lakshmanan, Gangeh, Mehrdad, Sadeghi-Naini, Ali, Dasgupta, Archya, Kolios, Michael C, Trudeau, Maureen, Gandhi, Sonal, Eisen, Andrea, Wright, Frances, Look-Hong, Nicole, Sahgal, Arjun, Stanisz, Greg, Brezden, Christine, Dinniwell, Robert, Tran, William T, Yang, Wei, Curpen, Belinda, Czarnota, Gregory J

“…Background Neoadjuvant chemotherapy (NAC) is the standard of care for patients with locally advanced breast cancer (LABC). The study was conducted to…”
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Optimization of microbubble enhancement of hyperthermia for cancer therapy in an in vivo breast tumour model by Sharma, Deepa, Cartar, Holliday, Law, Niki, Giles, Anoja, Farhat, Golnaz, Oelze, Michael, Czarnota, Gregory J

“…We have demonstrated that exposing human breast tumour xenografts to ultrasound-stimulated microbubbles enhances tumour cell death and vascular disruption…”
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Response monitoring of breast cancer patients receiving neoadjuvant chemotherapy using quantitative ultrasound, texture, and molecular features by Sannachi, Lakshmanan, Gangeh, Mehrdad, Tadayyon, Hadi, Sadeghi-Naini, Ali, Gandhi, Sonal, Wright, Frances C, Slodkowska, Elzbieta, Curpen, Belinda, Tran, William, Czarnota, Gregory J

“…Pathological response of breast cancer to chemotherapy is a prognostic indicator for long-term disease free and overall survival. Responses of locally advanced…”
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Evaluating the effects of radiation and acoustically-stimulated microbubble therapy in an in vivo breast cancer model by Sharma, Deepa, Tarapacki, Christine M, Kandavel, Harini, Panchalingam, Mailoan, Kim, Hyunjung Christina, Cartar, Holliday, Kaffas, Ahmed El, Czarnota, Gregory J

“…Ultrasound-stimulated microbubbles (USMB) cause localized vascular effects and sensitize tumors to radiation therapy (XRT). We investigated acoustic parameter…”
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Role of Acid Sphingomyelinase and Ceramide in Mechano-Acoustic Enhancement of Tumor Radiation Responses by El Kaffas, Ahmed, Al-Mahrouki, Azza, Hashim, Amr, Law, Niki, Giles, Anoja, Czarnota, Gregory J

“…High-dose radiotherapy (>8-10 Gy) causes rapid endothelial cell death via acid sphingomyelinase (ASMase)-induced ceramide production, resulting in biologically…”
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Ultrasound-stimulated microbubble enhancement of radiation response by Czarnota, Gregory J

“…Cancer therapies result in the killing of cancer cells but remain largely ineffective, with most patients dying of their disease. The methodology described…”
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Deep learning of quantitative ultrasound multi-parametric images at pre-treatment to predict breast cancer response to chemotherapy by Taleghamar, Hamidreza, Jalalifar, Seyed Ali, Czarnota, Gregory J., Sadeghi-Naini, Ali

“…In this study, a novel deep learning-based methodology was investigated to predict breast cancer response to neo-adjuvant chemotherapy (NAC) using the…”
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Ultrasound-stimulated microbubbles enhancement of fractionated radiation for tumor treatment by Sharma, Deepa, McNabb, Evan, Law, Niki, Cumal, Aaron, Czarnota, Gregory J

“…Radiation therapy (XRT) causes numerous biological changes in tumor microenvironment. Radiation vascular response, due to endothelial disruption, can influence…”
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Ultrasound-Based Radiation Enhancement: Concepts, Mechanisms and Therapeutic Applications by Sharma, Deepa, Czarnota, Gregory J.

“…Microbubbles have emerged as versatile carriers used both for cancer diagnosis and therapy. Microbubbles in the presence of ultrasound waves undergo…”
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Ultrasound microbubble potentiated enhancement of hyperthermia-effect in tumours by Sharma, Deepa, Giles, Anoja, Hashim, Amr, Yip, Jodi, Ji, Yipeng, Do, Natalie Ngoc Anh, Sebastiani, Juliana, Tran, William Tyler, Farhat, Golnaz, Oelze, Michael, Czarnota, Gregory J

“…It is now well established that for tumour growth and survival, tumour vasculature is an important element. Studies have demonstrated that…”
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Effect of Ultrasound‐Stimulated Microbubbles and Hyperthermia on Tumor Vasculature of Breast Cancer Xenograft by Sharma, Deepa, Cartar, Holliday, Quiaoit, Karina, Law, Niki, Giles, Anoja, Czarnota, Gregory J.

“…Objective The objective of the present study was to investigate the treatment effects of ultrasound‐stimulated microbubbles (USMB) and hyperthermia (HT) on…”
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Quantitative MRI Biomarkers of Stereotactic Radiotherapy Outcome in Brain Metastasis by Karami, Elham, Soliman, Hany, Ruschin, Mark, Sahgal, Arjun, Myrehaug, Sten, Tseng, Chia-Lin, Czarnota, Gregory J., Jabehdar-Maralani, Pejman, Chugh, Brige, Lau, Angus, Stanisz, Greg J., Sadeghi-Naini, Ali

“…About 20–40% of cancer patients develop brain metastases, causing significant morbidity and mortality. Stereotactic radiation treatment is an established…”
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Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism by Al-Mahrouki, Azza, Giles, Anoja, Hashim, Amr, Kim, Hyunjung Christina, El-Falou, Ahmad, Rowe-Magnus, Dean, Farhat, Golnaz, Czarnota, Gregory J

“…Ultrasound (US) stimulated microbubbles (MB) is a new treatment approach that sensitizes cancer cells to radiation (XRT). The molecular pathways in this…”
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