Search Results - "Czajlik, András"

New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176 by Huber, Anna, Hajdu, Dorottya, Bratschun-Khan, Doris, Gáspári, Zoltán, Varbanov, Mihayl, Philippot, Stéphanie, Fizil, Ádám, Czajlik, András, Kele, Zoltán, Sonderegger, Christoph, Galgóczy, László, Bodor, Andrea, Marx, Florentine, Batta, Gyula

“…Small, cysteine-rich and cationic proteins with antimicrobial activity are produced by diverse organisms of all kingdoms and represent promising molecules for…”
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Hard nut to crack: Solving the disulfide linkage pattern of the Neosartorya (Aspergillus) fischeri antifungal protein 2 by Váradi, Györgyi, Kele, Zoltán, Czajlik, András, Borics, Attila, Bende, Gábor, Papp, Csaba, Rákhely, Gábor, Tóth, Gábor K., Batta, Gyula, Galgóczy, László

“…As a consequence of the fast resistance spreading, a limited number of drugs are available to treat fungal infections. Therefore, there is an urgent need to…”
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Calcium binding of the antifungal protein PAF: Structure, dynamics and function aspects by NMR and MD simulations by Fizil, Ádám, Sonderegger, Christoph, Czajlik, András, Fekete, Attila, Komáromi, István, Hajdu, Dorottya, Marx, Florentine, Batta, Gyula

“…Calcium ions (Ca2+) play an important role in the toxicity of the cysteine-rich and cationic antifungal protein PAF from Penicillium chrysogenum: high…”
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Solution Structure, Dynamics, and New Antifungal Aspects of the Cysteine-Rich Miniprotein PAFC by Czajlik, András, Holzknecht, Jeanett, Galgóczy, László, Tóth, Liliána, Poór, Péter, Ördög, Attila, Váradi, Györgyi, Kühbacher, Alexander, Borics, Attila, Tóth, Gábor K, Marx, Florentine, Batta, Gyula

“…The genome of Q176 contains a gene coding for the 88-amino-acid (aa)-long glycine- and cysteine-rich antifungal protein C (PAFC). After maturation, the…”
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Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease by Kiss, Róbert, Zhu, Max, Jójárt, Balázs, Czajlik, András, Solti, Katalin, Fórizs, Balázs, Nagy, Éva, Zsila, Ferenc, Beke-Somfai, Tamás, Tóth, Gergely

“…DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a number of diseases, most of which are associated with high oxidative stress…”
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Resonance assignment of the Shank1 PDZ domain by Sánta, Anna, Czajlik, András, Batta, Gyula, Péterfia, Bálint, Gáspári, Zoltán

“…Shank proteins are among the most abundant and well-studied postsynaptic scaffold proteins. Their PDZ domain has unique characteristics as one of its loop…”
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Fine-tuning the extent and dynamics of binding cleft opening as a potential general regulatory mechanism in parvulin-type peptidyl prolyl isomerases by Czajlik, András, Kovács, Bertalan, Permi, Perttu, Gáspári, Zoltán

“…Parvulins or rotamases form a distinct group within peptidyl prolyl cis-trans isomerases. Their exact mode of action as well as the role of conserved residues…”
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Solution structure and novel insights into phylogeny and mode of action of the Neosartorya (Aspergillus) fischeri antifungal protein (NFAP) by Hajdu, Dorottya, Huber, Anna, Czajlik, András, Tóth, Liliána, Kele, Zoltán, Kocsubé, Sándor, Fizil, Ádám, Marx, Florentine, Galgóczy, László, Batta, Gyula

“…Small, cysteine-rich and cationic antifungal proteins from natural sources are promising candidates for the development of novel treatment strategies to…”
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Development of Cyclic NGR Peptides with Thioether Linkage: Structure and Dynamics Determining Deamidation and Bioactivity by Enyedi, Kata Nóra, Czajlik, András, Knapp, Krisztina, Láng, András, Majer, Zsuzsa, Lajkó, Eszter, Kőhidai, László, Perczel, András, Mező, Gábor

“…NGR peptides that recognize CD13 receptors in tumor neovasculature are of high interest, in particular due to their potential applications in drug targeting…”
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Structure and Stability of Short β-Peptide Nanotubes: A Non-Natural Representative of Collagen? by Czajlik, András, Beke, Tamás, Bottoni, Andrea, Perczel, András

“…Since secondary structure elements are known to play a key role in stabilizing the 3D-fold of proteins for the design of non-natural proteins composed of…”
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A Theoretical Comparison of Self-Assembling α- and β-Peptide Nanostructures: Toward Design of β-Barrel Frameworks by Beke, Tamás, Czajlik, András, Bálint, Balázs, Perczel, András

“…Self-assembling peptide-based nanotubes are among the most investigated bioactive compounds as a result of their numerous potential applications as novel…”
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Mapping of the Lipid-Binding Regions of the Antifungal Protein NFAP2 by Exploiting Model Membranes by Pavela, Olivér, Juhász, Tünde, Tóth, Liliána, Czajlik, András, Batta, Gyula, Galgóczy, László, Beke-Somfai, Tamás

“…Fungal infections with high mortality rates represent an increasing health risk. The Neosartorya (Aspergillus) fischeri antifungal protein 2 (NFAP2) is a…”
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Confirmation of the Disulfide Connectivity and Strategies for Chemical Synthesis of the Four-Disulfide-Bond-Stabilized Aspergillus giganteus Antifungal Protein, AFP by Váradi, Györgyi, Batta, Gyula, Galgóczy, László, Hajdu, Dorottya, Fizil, Ádám, Czajlik, András, Virágh, Máté, Kele, Zoltán, Meyer, Vera, Jung, Sascha, Marx, Florentine, Tóth, Gábor K.

“…Emerging fungal infections require new, more efficient antifungal agents and therapies. AFP, a protein from Aspergillus giganteus with four disulfide bonds, is…”
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DMSO-Induced Unfolding of the Antifungal Disulfide Protein PAF and Its Inactive Variant: A Combined NMR and DSC Study by Czajlik, András, Batta, Ágnes, Kerner, Kinga, Fizil, Ádám, Hajdu, Dorottya, Raics, Mária, Kövér, Katalin E, Batta, Gyula

“…PAF and related antifungal proteins are promising antimicrobial agents. They have highly stable folds around room temperature due to the presence of 3-4…”
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Structure, enzymatic stability and antitumor activity of sea lamprey GnRH-III and its dimer derivatives by Mező, Gábor, Czajlik, András, Manea, Marilena, Jakab, Annamária, Farkas, Viktor, Majer, Zsuzsa, Vass, Elemér, Bodor, Andrea, Kapuvári, Bence, Boldizsár, Mariann, Vincze, Borbála, Csuka, Orsolya, Kovács, Magdolna, Przybylski, Michael, Perczel, András, Hudecz, Ferenc

“…Direct antitumor activity of sea lamprey ( Petromyzon marinus) gonadotropin-releasing hormone III (Glp-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH 2; lGnRH-III) was…”
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Investigation of penetratin peptides. Part 2. In vitro uptake of penetratin and two of its derivatives by Letoha, Tamás, Gaál, Szilvia, Somlai, Csaba, Venkei, Zsolt, Glavinas, Hristos, Kusz, Erzsébet, Duda, Ernö, Czajlik, András, Peták, Ferenc, Penke, Botond

“…As endocytic uptake of the Antennapedia homeodomain‐derived penetratin peptide (RQIKIWFQNRRMKWKK) is finally being revealed, some of the early views about…”
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Investigation of penetratin peptides Part 1. The environment dependent conformational properties of penetratin and two of its derivatives by Czajlik, András, Meskó, Eszter, Penke, Botond, Perczel, András

“…The homeodomain, the DNA‐binding domain of Antennapedia homeoprotein, is composed of three α‐helices and one β‐turn between helices II and III. Its third helix…”
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Local protein backbone folds determined by calculated NMR chemical shifts by Czajlik, András, Hudáky, Ilona, Perczel, András

“…NMR chemical shifts (CSs: δNNH, δCα, δCβ, δC′, δHNH, and δHα) were computed for the amino acid backbone conformers (αL, βL, γL, δL, εL, αD, γD, δD, and εD…”
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sup 1^H, ^sup 15^N and ^sup 13^C backbone chemical shift assignment of titin domains A59-A60 and A60 alone by Czajlik, András, Thompson, Gary S, Khan, Ghulam N, Kalverda, Arnout P, Homans, Steve W, Trinick, John

“…The giant protein titin is the third most abundant protein of vertebrate striated muscle. The titin molecule is >1 [mu]m long and spans half the sarcomere,…”
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1H, 15N and 13C backbone chemical shift assignment of titin domains A59–A60 and A60 alone by Czajlik, András, Thompson, Gary S., Khan, Ghulam N., Kalverda, Arnout P., Homans, Steve W., Trinick, John

“…The giant protein titin is the third most abundant protein of vertebrate striated muscle. The titin molecule is >1 μm long and spans half the sarcomere, from…”
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