Search Results - "Czachowski, Cristine L."

A critical review of front‐loading: A maladaptive drinking pattern driven by alcohol's rewarding effects by Ardinger, Cherish E., Lapish, Christopher C., Czachowski, Cristine L., Grahame, Nicholas J.

“…Front‐loading is a drinking pattern in which alcohol intake is skewed toward the onset of reward access. This phenomenon has been reported across several…”
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Effect of operant self‐administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens by Doyon, William M., Anders, Sheneil K., Ramachandra, Vorani S., Czachowski, Cristine L., Gonzales, Rueben A.

“…Although operant ethanol self‐administration can increase accumbal dopamine activity, the relationship between dopamine and ethanol levels during consumption…”
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Evaluating habit formation across pairs of female and male selectively bred alcohol-preferring and non-preferring rats by Haines, Kari M., Czachowski, Cristine L.

“…Some individuals with alcohol use disorder (AUD) continue to drink because they have developed a habit where they do not consider the consequences of their…”
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Effects of group II metabotropic glutamate receptor modulation on ethanol- and sucrose-seeking and consumption in the rat by Windisch, Kyle A., Czachowski, Cristine L.

“…Previous studies suggest that group II metabotropic glutamate receptors (mGluR2/3) are involved in regulating ethanol-seeking and consumption. The mGluR2/3…”
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The Effects of Long‐Term Varenicline Administration on Ethanol and Sucrose Seeking and Self‐Administration in Male P Rats by Czachowski, Cristine L., Froehlich, Janice C., DeLory, Michael

“…Background Varenicline, a partial agonist at α4β2 and full agonist at α7 nicotinic cholinergic receptors, is FDA‐approved for treatment of smoking cessation…”
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Increased Delay Discounting Tracks with a High Ethanol-Seeking Phenotype and Subsequent Ethanol Seeking But Not Consumption by Beckwith, S. Wesley, Czachowski, Cristine L.

“…Background Increased levels of delay discounting have been associated with alcoholism and problematic levels of drinking. Attempts to assess the directionality…”
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Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat by Verplaetse, Terril L., Czachowski, Cristine L.

“…Rationale Evidence suggests that the noradrenergic system mediates ethanol reinforcement. However, preclinical studies suggest that noradrenergic antagonists…”
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Differential effects of quinine adulteration of alcohol on seeking and drinking by McCane, Aqilah M., Auterson, Curtis D., DeLory, Michael J., Lapish, Christopher C., Czachowski, Cristine L.

“…Alcohol dependence is characterized by compulsive alcohol use. Alcohol-paired stimuli can drive compulsive alcohol use, induce craving, and lead to relapse…”
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Tolcapone Suppresses Ethanol Intake in Alcohol-Preferring Rats Performing a Novel Cued Access Protocol by McCane, Aqilah M., Czachowski, Cristine L., Lapish, Christopher C.

“…Background Dopamine (DA) has been shown to play a central role in regulating motivated behavior and encoding reward. Chronic drug abuse elicits a state of…”
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Effects of Prazosin, an α1-Adrenergic Receptor Antagonist, on the Seeking and Intake of Alcohol and Sucrose in Alcohol-Preferring (P) Rats by Verplaetse, Terril L., Rasmussen, Dennis D., Froehlich, Janice C., Czachowski, Cristine L.

“…Background:  Previous studies show that prazosin, an α1‐adrenergic receptor antagonist, decreases alcohol drinking in animal models of alcohol use and…”
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Impulsive Choices Emerge When the Anterior Cingulate Cortex Fails to Encode Deliberative Strategies by White, Shelby M., Morningstar, Mitchell D., De Falco, Emanuela, Linsenbardt, David N., Ma, Baofeng, Parks, Macedonia A., Czachowski, Cristine L., Lapish, Christopher C.

“…Impulsive individuals excessively discount the value of delayed rewards, and this is thought to reflect deficits in brain regions critical for impulse control…”
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Systemic and intraaccumbens mGluR2/3 agonism attenuate ethanol-reinforced appetitive responding by Windisch, Kyle A, Czachowski, Cristine L

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Acamprosate and naltrexone treatment effects on ethanol and sucrose seeking and intake in ethanol-dependent and nondependent rats by Czachowski, Cristine L., DeLory, Michael J.

“…Rationale Two pharmacotherapies are approved for treating alcohol craving (acamprosate and naltrexone), but both have shown mixed findings in animals and…”
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Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats by McCane, Aqilah M., DeLory, Michael J., Timm, Maureen M., Janetsian-Fritz, Sarine S., Lapish, Christopher C., Czachowski, Cristine L.

“…Polymorphisms of the catechol-O-methyl transferase (COMT) gene have been associated with alcoholism, suggesting that alterations in the metabolism of…”
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Alterations in ethanol seeking and self-administration following yohimbine in selectively bred alcohol-preferring (P) and high alcohol drinking (HAD-2) rats by Bertholomey, Megan L., Verplaetse, Terril L., Czachowski, Cristine L.

“…► Yohimbine increased ethanol self-administration and reinstated ethanol seeking. ► P and HAD-2 do not differ in the effects of yohimbine on ethanol…”
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Behavioral and Neurotransmitter Specific Roles for the Ventral Tegmental Area in Reinforcer-Seeking and Intake by Czachowski, Cristine L., DeLory, Michael J., Pope, Jason D.

“…Background The ventral tegmental area (VTA) is a pivotal relay site within the reinforcement circuit that has been shown to play a role in ethanol…”
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Neuropeptide Y (NPY) in the central nucleus of the amygdala (CeA) does not affect ethanol-reinforced responding in binge-drinking, nondependent rats by Henderson, Angela N., Czachowski, Cristine L.

“…The central nucleus of the amygdala (CeA) has been implicated as having a significant role in mediating alcohol-drinking behavior. Neuropeptide Y (NPY) has…”
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Intravenous alcohol self-administration in the P rat by Windisch, Kyle A, Kosobud, Ann E.K, Czachowski, Cristine L

“…Abstract Alcohol consumption produces a complex array of effects that can be divided into two types: the explicit pharmacological effects of ethanol (which can…”
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Manipulations of Serotonin Function in the Nucleus Accumbens Core Produce Differential Effects on Ethanol and Sucrose Seeking and Intake by Czachowski, Cristine L.

“…Objective: Behaviorally relevant stimuli, including alcohol, are processed through the nucleus accumbens/ventral tegmental area (VTA)/prefrontal cortex…”
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Dopamine Activity in the Nucleus Accumbens During Consummatory Phases of Oral Ethanol Self-Administration by Doyon, William M., York, Jennifer L., Diaz, Laurea M., Samson, Herman H., Czachowski, Cristine L., Gonzales, Rueben A.

“…Background: This present study was designed to clarify the role of dopamine in the nucleus accumbens during operant ethanol self‐administration by separating…”
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