Search Results - "Cyrus Khandanpour"

From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation by Möröy, Tarik, Vassen, Lothar, Wilkes, Brian, Khandanpour, Cyrus

“…The DNA-binding zinc finger transcription factors Gfi1 and Gfi1b were discovered more than 20 years ago and are recognized today as major regulators of both…”
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Editorial: New emerging functions of transcription factors and RNA-binding proteins in the development of hematological malignancies by Möröy, Tarik, Khandanpour, Cyrus

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Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications by Möröy, Tarik, Khandanpour, Cyrus

“…Growth factor independence 1 (GFI1) is a DNA binding zinc finger protein, which can mediate transcriptional repression mainly by recruiting histone-modifying…”
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The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape by de Jong, Madelon M. E., Kellermayer, Zoltán, Papazian, Natalie, Tahri, Sabrin, Hofste op Bruinink, Davine, Hoogenboezem, Remco, Sanders, Mathijs A., van de Woestijne, Pieter C., Bos, P. Koen, Khandanpour, Cyrus, Vermeulen, Jessica, Moreau, Philippe, van Duin, Mark, Broijl, Annemiek, Sonneveld, Pieter, Cupedo, Tom

“…Progression and persistence of malignancies are influenced by the local tumor microenvironment, and future eradication of currently incurable tumors will, in…”
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Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation by Möröy, Tarik, Khandanpour, Cyrus

“…Highlights ► Gfi1 is required for T-cell development. ► Gfi1 is required for B-cell development and restricts Immunoglobulin production. ► Gfi1 promotes Th2…”
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The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma by Lacroix, Marion, Beauchemin, Hugues, Khandanpour, Cyrus, Möröy, Tarik

“…DDX3X is an RNA helicase with many functions in RNA metabolism such as mRNA translation, alternative pre-mRNA splicing and mRNA stability, but also plays a…”
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LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML by Barth, Jessica, Abou-El-Ardat, Khalil, Dalic, Denis, Kurrle, Nina, Maier, Anna-Maria, Mohr, Sebastian, Schütte, Judith, Vassen, Lothar, Greve, Gabriele, Schulz-Fincke, Johannes, Schmitt, Martin, Tosic, Milica, Metzger, Eric, Bug, Gesine, Khandanpour, Cyrus, Wagner, Sebastian A., Lübbert, Michael, Jung, Manfred, Serve, Hubert, Schüle, Roland, Berg, Tobias

“…LSD1 has emerged as a promising epigenetic target in the treatment of acute myeloid leukemia (AML). We used two murine AML models based on retroviral…”
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Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner by Al-Matary, Yahya S, Botezatu, Lacramioara, Opalka, Bertram, Hönes, Judith M, Lams, Robert F, Thivakaran, Aniththa, Schütte, Judith, Köster, Renata, Lennartz, Klaus, Schroeder, Thomas, Haas, Rainer, Dührsen, Ulrich, Khandanpour, Cyrus

“…The growth of malignant cells is not only driven by cell-intrinsic factors, but also by the surrounding stroma. Monocytes/Macrophages play an important role in…”
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GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 by Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik

“…GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia…”
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Multiple myeloma in the young: insights on prognosis, clinical features and treatment outcome derived from nationwide German registry data and a nested multicenter sample by Kamili, Abdulaziz, Ahmadi, Paymon, Leypoldt, Lisa, Marquard, Franziska, Schaefers, Christoph, Kosch, Ricardo, Peters, Frederik, Kusche, Henrik, Zamrik, Tanja, Hanoun, Christine, Seib, Maximilian, Shumilov, Evgenii, Leitner, Theo, Khandanpour, Cyrus, Bokemeyer, Carsten, Weisel, Katja, Ghandili, Susanne

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Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB by Alhosani, Faisal, Ilce, Burcu Yener, Alhamidi, Reem Sami, Bhamidimarri, Poorna Manasa, Hamad, Alaa Mohamed, Alkhayyal, Noura, Künstner, Axel, Khandanpour, Cyrus, Busch, Hauke, Al-Ramadi, Basel, Sayed, Kadria, AlFazari, Ali, Bendardaf, Riyad, Hamoudi, Rifat

“…The immune system plays a critical role in inflammation by initiating responses to infections or tissue damage. The nuclear factor-κB (NF-κB) pathway plays a…”
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A Dominant-Negative GFI1B Mutation in the Gray Platelet Syndrome by Monteferrario, Davide, Bolar, Nikhita A, Marneth, Anna E, Hebeda, Konnie M, Bergevoet, Saskia M, Veenstra, Hans, Laros-van Gorkom, Britta A.P, MacKenzie, Marius A, Khandanpour, Cyrus, Botezatu, Lacramiora, Fransen, Erik, Van Camp, Guy, Duijnhouwer, Anthonie L, Salemink, Simone, Willemsen, Brigith, Huls, Gerwin, Preijers, Frank, Van Heerde, Waander, Jansen, Joop H, Kempers, Marlies J.E, Loeys, Bart L, Van Laer, Lut, Van der Reijden, Bert A

“…A large family is described with gray platelet syndrome due to an autosomal dominant inheritance pattern related to a dominant-negative mutation in GFI1B . The…”
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Origin of the brush cell lineage in the mouse intestinal epithelium by Bjerknes, Matthew, Khandanpour, Cyrus, Möröy, Tarik, Fujiyama, Tomoyuki, Hoshino, Mikio, Klisch, Tiemo J., Ding, Qian, Gan, Lin, Wang, Jiafang, Martín, Martín G., Cheng, Hazel

“…Mix progenitors are short-lived multipotential cells formed as intestinal epithelial stem cells initiate a differentiation program. Clone dynamics indicates…”
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Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies by Schütte, Judith, Reusch, Julia, Khandanpour, Cyrus, Eisfeld, Christine

“…Structural variants (SV) are changes in the genomic landscape that can alter gene expression levels and thus lead to disease development. The most common and…”
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Effectiveness of high efficiency particulate (HEPA) air condition combined with the antifungal prophylaxis on incidence, morbidity and mortality of invasive fungal infections in patients with acute myeloid leukemia: a retrospective single-center study by Preyer, Linda, Vettorazzi, Eik, Fiedler, Walter, Rohde, Holger, Stemler, Jannik, Gönner, Saskia, Bokemeyer, Carsten, Khandanpour, Cyrus, Wortmann, Friederike, Kebenko, Maxim

“…Our monocentric and retrospective study aimed to investigate the clinical effectivity of HEPA filters in combination with the antifungal drug prophylaxis in…”
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Curcumin as an Epigenetic Therapeutic Agent in Myelodysplastic Syndromes (MDS) by Xie, Xiaoqing, Frank, Daria, Patnana, Pradeep Kumar, Schütte, Judith, Al-Matary, Yahya, Liu, Longlong, Wei, Lanying, Dugas, Martin, Varghese, Julian, Nimmagadda, Subbaiah Chary, Khandanpour, Cyrus

“…Growth Factor Independence 1 (GFI1) is a transcription factor with an important role in the regulation of development of myeloid and lymphoid cell lineages and…”
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Long-term survival and polyclonal immunoglobulin reconstitution after allogeneic stem cell transplantation in multiple myeloma by Eisfeld, Christine, Eßeling, Eva, Wullenkord, Ramona, Khandanpour, Cyrus, Reusch, Julia, Mikesch, Jan-Henrik, Reicherts, Christian, Kerkhoff, Andrea, Schliemann, Christoph, Kessler, Torsten, Mesters, Rolf M., Berdel, Wolfgang E., Lenz, Georg, Stelljes, Matthias

“…Despite significant progress made in the treatment of patients with multiple myeloma (MM) in the last decade, for patients with early relapse or rapidly…”
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Case report: Tenosynovial giant cell tumor by Fähnrich, Anke, Gasimova, Zhala, Maluje, Yamil, Ott, Fabian, Sievert, Helen, Fliedner, Stephanie, Reimer, Niklas, Künstner, Axel, Gebauer, Niklas, Kebenko, Maxim, von Bubnoff, Nikolas, Kirfel, Jutta, Sailer, Verena-Wilbeth, Röcken, Christoph, Konukiewitz, Bjoern, Klapper, Wolfram, Frydrychowicz, Alex, Mogadas, Sam, Huebner, Gerdt, Busch, Hauke, Khandanpour, Cyrus

“…Tenosynovial giant cell tumor (TGCT) is a rare type of tumor that originates from the synovium of joints and tendon sheaths. It is characterized by recurring…”
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Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1 by Fraszczak, Jennifer, Helness, Anne, Chen, Riyan, Vadnais, Charles, Robert, François, Khandanpour, Cyrus, Möröy, Tarik

“…A regulatory circuit that controls myeloid versus B lymphoid cell fate in hematopoietic progenitors has been proposed, in which a network of the transcription…”
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Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma by Patra-Kneuer, Maria, Chang, Gaomei, Xu, Wendan, Augsberger, Christian, Grau, Michael, Zapukhlyak, Myroslav, Ilieva, Kristina, Landgraf, Karin, Mangelberger-Eberl, Doris, Yousefi, Kasra, Berning, Philipp, Kurz, Katrin S., Ott, German, Klener, Pavel, Khandanpour, Cyrus, Horna, Pedro, Schanzer, Jürgen, Steidl, Stefan, Endell, Jan, Heitmüller, Christina, Lenz, Georg

“…BackgroundDespite recent advances in the treatment of aggressive lymphomas, a significant fraction of patients still succumbs to their disease. Thus, novel…”
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