Search Results - "Cyril, Vidusha"

Combination of Ibrutinib with CD19 Chimeric Antigen Receptor (CAR) T Cells Suggests Greater Contribution to CAR T-Cell Efficacy Than Other Approved BTK Inhibitors in the Preclinical Setting by Plaks, Vicki, Cyril, Vidusha, Riedell, Peter A, Zhao, Qianqian, Hall, Jason, Tan, Joel, Harb, Diala, Davids, Matthew S

“…Background:CD19-directed CAR T-cell therapy has demonstrated remarkable clinical benefits for patients with B-cell malignancies, but impaired CAR T-cell…”
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Gold(III) Macrocycles: Nucleotide-Specific Unconventional Catalytic Inhibitors of Human Topoisomerase I by Akerman, Kate J, Fagenson, Alexander M, Cyril, Vidusha, Taylor, Michael, Muller, Mark T, Akerman, Matthew P, Munro, Orde Q

“…Topoisomerase IB (Top1) is a key eukaryotic nuclear enzyme that regulates the topology of DNA during replication and gene transcription. Anticancer drugs that…”
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A solid phase assay for topoisomerase I interfacial poisons and catalytic inhibitors by Cyril, Vidusha, Muller, Mark T.

“…We report a mechanism-based screening technique to rapidly identify eukaryotic topoisomerase I targeting agents. The method is based on genetic tagging of…”
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