Search Results - "Cyr, Amber"

Abstract 2566: CYT01B suppresses RAD51 focus formation and induces replication catastrophe following AID induced DNA damage by Day, Melinda, Cyr, Amber, Maclay, Tyler, Mills, Kevin

“…Activation Induced Cytidine Deaminase (AID) is a DNA-directed cytidine deaminase that plays a critical role in somatic hypermutation and immunoglobulin class…”
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Targeting Homologous Recombination in Lymphoid Malignancies: Evaluation of Four Small Molecule Inhibitors of RAD51 by Day, Melinda, Maclay, Tyler, Cyr, Amber, Hasham, Muneer G, Chow, Kin-hoe, Keniston, ED, Mills, Kevin

“…Genomic instability is recognized as a driver of tumorigenesis and cancer progression. Loss of tumor suppressors or activation of oncogenes can induce DNA…”
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Abstract 347: Targeting the AICDA/RAD51 axis: A novel gain-of-function synthetic lethal therapy for the treatment of AICDA-expressing cancers by Hasham, Muneer, Chow, Kin-hoe, Maclay, Tyler, Cyr, Amber, Patrick, Darryl, Day, Melinda, Mills, Kevin D.

“…A key characteristic of many cancers is genomic instability, and is often associated with poor prognosis. While genomic instability can promote tumorigenesis,…”
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A Small Molecule RAD51 Inhibitor Preferentially Affects Cells Expressing High Cytidine Deaminase Activity by Mills, Kevin, Cyr, Amber, Maclay, Tyler, Day, Melinda, Hasham, Muneer G, Khalil, Andre

“…RAD51 is a homologous recombination factor critical for DNA replication, recombination, and DNA double strand break repair. RAD51 forms nucleoprotein filaments…”
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Synthetic Lethality Targeting the Aid/RAD51 Axis for Treatment of AICDA-Expressing Lymphoma by Mills, Kevin, Cyr, Amber, Maclay, Tyler, Day, Melinda, Patrick, Darryl, Clas, Sophie-Dorothee, Hasham, Muneer G, Chow, Kin-hoe

“…Activation Induced Cytidine Deaminase (AICDA or AID) is a DNA directed cytidine deaminase that induces somatic hypermutation and immunoglobulin class switching…”
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Abstract 2481: RAD51 and AICDA define a new synthetic lethal interaction that is targetable in multiple tumor types by Mills, Kevin D., Roche, Marly I., Cyr, Amber, Maclay, Tyler, Hasham, Muneer G., Lamont, Kristin, Branca, Jane, Cavallo, Francesca, Jasin, Maria, Stern, Alvin, Kwon, Youngho, Zhao, Weixing, Sung, Patrick

“…Antigen stimulated B-cells transiently express Activation Induced Cytidine Deaminase (AID) which initiates point mutations and DNA double strand breaks (DSB)…”
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