Search Results - "Cynthia L. Grosskreutz"

Efficacy and Safety of Intravenous Secukinumab in Noninfectious Uveitis Requiring Steroid-Sparing Immunosuppressive Therapy by Letko, Erik, MD, Yeh, Steven, MD, Foster, C. Stephen, MD, Pleyer, Uwe, MD, Brigell, Mitchell, PhD, Grosskreutz, Cynthia L., MD, PhD

“…Purpose Secukinumab, a fully human anti–interleukin-17A monoclonal antibody, exhibited promising activity in a proof-of-concept study when administered in…”
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Mechanisms of retinal ganglion cell injury and defense in glaucoma by Qu, Juan, Wang, Danyi, Grosskreutz, Cynthia L.

“…Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness. Over the past decade and a half, information has begun to…”
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A proteogenomic signature of age-related macular degeneration in blood by Emilsson, Valur, Gudmundsson, Elias F., Jonmundsson, Thorarinn, Jonsson, Brynjolfur G., Twarog, Michael, Gudmundsdottir, Valborg, Li, Zhiguang, Finkel, Nancy, Poor, Stephen, Liu, Xin, Esterberg, Robert, Zhang, Yiyun, Jose, Sandra, Huang, Chia-Ling, Liao, Sha-Mei, Loureiro, Joseph, Zhang, Qin, Grosskreutz, Cynthia L., Nguyen, Andrew A., Huang, Qian, Leehy, Barrett, Pitts, Rebecca, Aspelund, Thor, Lamb, John R., Jonasson, Fridbert, Launer, Lenore J., Cotch, Mary Frances, Jennings, Lori L., Gudnason, Vilmundur, Walshe, Tony E.

“…Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood…”
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Calpain activation in experimental glaucoma by Huang, Wei, Fileta, John, Rawe, Ian, Qu, Juan, Grosskreutz, Cynthia L

“…Glaucoma is a neurodegenerative disease in which elevated intraocular pressure (IOP) leads to progressive loss of retinal ganglion cells (RGCs) and blindness…”
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Global gene expression changes in rat retinal ganglion cells in experimental glaucoma by Wang, Dan Yi, Ray, Arjun, Rodgers, Kathryn, Ergorul, Ceren, Hyman, Bradley T, Huang, Wei, Grosskreutz, Cynthia L

“…Intraocular pressure (IOP) is an important risk factor in glaucoma. Gene expression changes were studied in glaucomatous rat retinal ganglion cells (RGCs) to…”
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Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma by Huang, Wei, Fileta, John B, Dobberfuhl, Adam, Filippopolous, Theodoros, Guo, Yan, Kwon, Gina, Grosskreutz, Cynthia L

“…Increased intraocular pressure (IOP) leads, by an unknown mechanism, to apoptotic retinal ganglion cell (RGC) death in glaucoma. We now report cleavage of the…”
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DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity by Fan, Bao Jian, Pasquale, Louis, Grosskreutz, Cynthia L, Rhee, Douglas, Chen, Teresa, DeAngelis, Margaret M, Kim, Ivana, del Bono, Elizabeth, Miller, Joan W, Li, Tiansen, Haines, Jonathan L, Wiggs, Janey L

“…Pseudoexfoliation syndrome is a major risk factor for glaucoma in many populations throughout the world. Using a U.S. clinic-based case control sample with…”
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Transcriptional Up-Regulation and Activation of Initiating Caspases in Experimental Glaucoma by Huang, Wei, Dobberfuhl, Adam, Filippopoulos, Theodoros, Ingelsson, Martin, Fileta, John B., Poulin, Nathaniel R., Grosskreutz, Cynthia L.

“…In glaucoma, retinal ganglion cells (RGCs) die by apoptosis, generally attributed to an elevated intraocular pressure (IOP). We now describe the impact of…”
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Glaucoma - Next Generation Therapeutics: Impossible to Possible by Adams, Christopher M., Stacy, Rebecca, Rangaswamy, Nalini, Bigelow, Chad, Grosskreutz, Cynthia L., Prasanna, Ganesh

“…The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct…”
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Effect of brimonidine on retinal blood flow autoregulation in primary open-angle glaucoma by Feke, Gilbert T, Hazin, Ribhi, Grosskreutz, Cynthia L, Pasquale, Louis R

“…To determine whether topically applied brimonidine affects the retinal hemodynamic autoregulatory response to posture change in patients with normal tension…”
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Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation by Wu, Hai-Yan, Hudry, Eloise, Hashimoto, Tadafumi, Kuchibhotla, Kishore, Rozkalne, Anete, Fan, Zhanyun, Spires-Jones, Tara, Xie, Hong, Arbel-Ornath, Michal, Grosskreutz, Cynthia L, Bacskai, Brian J, Hyman, Bradley T

“…Amyloid beta (Abeta)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's disease (AD) brain, but whether and how plaques induce these…”
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A Randomized, Double-Masked, Multicenter Trial of Topical Acrizanib (LHA510), a Tyrosine Kinase VEGF-Receptor Inhibitor, in Treatment-Experienced Subjects With Neovascular Age-Related Macular Degeneration by Poor, Stephen H., Weissgerber, Georges, Adams, Christopher M., Bhatt, Harit, Browning, David J., Chastain, James, Ciulla, Thomas A., Ferriere, Michael, Gedif, Kinfemichael, Glazer, Louis C., Joondeph, Brian C., Normand, Guillaume, Sheth, Veeral, Watters, Christie, Grosskreutz, Cynthia L.

“…To evaluate whether topical acrizanib (LHA510), a small-molecule vascular endothelial growth factor receptor inhibitor, could suppress the need for…”
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Anti-brolucizumab immune response as one prerequisite for rare retinal vasculitis/retinal vascular occlusion adverse events by Karle, Anette C, Wrobel, Matthias B, Koepke, Stephan, Gutknecht, Michael, Gottlieb, Sascha, Christen, Brigitte, Rubic-Schneider, Tina, Pruimboom-Brees, Ingrid, Leber, Xavier Charles, Scharenberg, Meike, Maciejewski, Benjamin, Turner, Oliver, Saravanan, Chandra, Huet, Francois, Littlewood-Evans, Amanda, Clemens, Andreas, Grosskreutz, Cynthia L, Kearns, Jeffrey D, Mehan, Pawan, Schmouder, Robert L, Sasseville, Vito, Brees, Dominique

“…In October 2019, Novartis launched brolucizumab, a single-chain variable fragment molecule targeting vascular endothelial growth factor A, for the treatment of…”
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Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open‐Angle Glaucoma by Wang, Shirley V., Li, Ning, Rice, Dennis S., Grosskreutz, Cynthia L., Dryja, Thaddeus P., Prasanna, Ganesh, Lii, Joyce, Gagne, Joshua J.

“…We sought to refine understanding about associations identified in prior studies between angiotensin‐II receptor blockers, metformin, selective serotonin…”
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A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab by Kearns, Jeffrey D, Wassmann, Paul, Olgac, Ufuk, Fichter, Marie, Christen, Brigitte, Rubic-Schneider, Tina, Koepke, Stephan, Cochin de Billy, Benjamin, Ledieu, David, Andre, Cedric, Hawtin, Stuart, Fischer, Benoit, Moretti, Francesca, Hug, Christian, Bepperling, Alexander, Brannetti, Barbara, Mendez-Garcia, Celia, Littlewood-Evans, Amanda, Clemens, Andreas, Grosskreutz, Cynthia L, Mehan, Pawan, Schmouder, Robert L, Sasseville, Vito, Brees, Dominique, Karle, Anette C

“…Immunogenicity against intravitreally administered brolucizumab has been previously described and associated with cases of severe intraocular inflammation,…”
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Glaucoma in Eyes With Severe Chemical Burn, Before and After Keratoprosthesis by Cade, Fabiano, Grosskreutz, Cynthia L, Tauber, Allyson, Dohlman, Claes H

“…PURPOSE:The purpose of this study was to evaluate the incidence of glaucoma in eyes with severe chemical burn, before and after keratoprosthesis. METHODS:A…”
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Predictability and limitations of non-invasive murine tonometry: Comparison of two devices by Filippopoulos, Theodoros, Matsubara, Akihisa, Danias, John, Huang, Wei, Dobberfuhl, Adam, Ren, Lizhen, Mittag, Thomas, Miller, Joan W., Grosskreutz, Cynthia L.

“…Our purpose was to evaluate the accuracy, reproducibility and predictive ability of two non-invasive tonometers developed for intraocular pressure (IOP)…”
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Dry Eye Signs and Symptoms Persist During Systemic Neutralization of IL-1β by Canakinumab or IL-17A by Secukinumab by Grosskreutz, Cynthia L, Hockey, Hans-Ulrich, Serra, Denise, Dryja, Thaddeus P

“…PURPOSE:To evaluate whether inhibition of the proinflammatory cytokines IL-1β or IL-17A by canakinumab or secukinumab, respectively, influence the signs and…”
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Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay by Wu, Hai-Yan, Hudry, Eloise, Hashimoto, Tadafumi, Uemura, Kengo, Fan, Zhan-Yun, Berezovska, Oksana, Grosskreutz, Cynthia L, Bacskai, Brian J, Hyman, Bradley T

“…Calcineurin (CaN) activation is critically involved in the regulation of spine morphology in response to oligomeric amyloid-β (Aβ) as well as in synaptic…”
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Patient-Reported Outcomes in RLBP1 Retinal Dystrophy: Longitudinal Assessment in a Prospective Natural History Study by Whelan, James, Green, Jane, Burstedt, Marie, Greco, Erin, Ni, Xiao, Spera, Claudio, Mullins, Anmol, Deslandes, Jean-Yves, Su, Zhenzhong, Wald, Michael, Grosskreutz, Cynthia L., Normand, Guillaume, Charil, Arnaud, Lu, Darlene, Stasi, Kalliopi, Holopigian, Karen

“…To evaluate the performance of two non-disease-specific patient-reported outcome (PRO) instruments, the National Eye Institute Visual Function Questionnaire-25…”
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